CAMK2B calcium/calmodulin dependent protein kinase II beta [Homo sapiens (human)] - Gene

Summary

Official Symbol: CAMK2Bprovided by HGNC
Official Full Name: calcium/calmodulin dependent protein kinase II betaprovided by HGNC
Primary source: HGNC:HGNC:1461
See related: Ensembl:ENSG00000058404 MIM:607707; AllianceGenome:HGNC:1461
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CAM2; CAMK2; CAMKB; MRD54; CaMKIIbeta
Summary: The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Expression: Biased expression in brain (RPKM 44.0), heart (RPKM 16.4) and 2 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7p13

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (44217154..44326013, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (44375741..44485432, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (44256753..44365193, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Understanding the pathogenetic mechanisms underlying altered neuronal function associated with CAMK2B mutations.
Title: Understanding the pathogenetic mechanisms underlying altered neuronal function associated with CAMK2B mutations.
Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation.
Title: Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation.
CaMKIIbeta in Neuronal Development and Plasticity: An Emerging Candidate in Brain Diseases.
Title: CaMKIIβ in Neuronal Development and Plasticity: An Emerging Candidate in Brain Diseases.
CaMKII regulates KCNQ1 at S484 during sustained beta-AR stimulation to inhibit IKs. The ability of CaMKII to inhibit IKs may contribute to arrhythmogenicity during HF.
Title: Calcium/calmodulin-dependent protein kinase II regulation of I(Ks) during sustained β-adrenergic receptor stimulation.
The importance of CAMK2A and CAMK2B and their auto-phosphorylation in human brain function.
Title: De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability.
TGFbeta elevated the expression of CamK IIbeta and CamK IIdelta, while siRNA silencing of those two subtypes significantly reduced TGFbeta-mediated expression of collagen A1 and fibronectin 1.
Title: Ca(2+)/calmodulin-dependent protein kinase IIβ and IIδ mediate TGFβ-induced transduction of fibronectin and collagen in human pulmonary fibroblasts.
Due to similarity of structure variations, we suggest that these compounds may have an effect on beta-CaMKII and that sengesterone may have a similar efficacy as the control.
Title: Possible inhibitor from traditional Chinese medicine for the β form of calcium-dependent protein kinase type II in the treatment of major depressive disorder.
beta-carotene reverses the IL-1beta-mediated reduction in paraoxonase-1 expression via induction of the CaMKKII pathway in human endothelial cells
Title: β-carotene reverses the IL-1β-mediated reduction in paraoxonase-1 expression via induction of the CaMKKII pathway in human endothelial cells.
Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation.
Title: Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation.
Promoter methylations of CAMK2B and ARFGEF1 are novel epigenetic markers identified in breast cancer cell lines.
Title: Downregulation of ARFGEF1 and CAMK2B by promoter hypermethylation in breast cancer cells.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Intellectual disability, autosomal dominant 54 MedGen: C4540484 OMIM: 617799 GeneReviews: Not available	Compare labs

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2023-01-25) ClinGen Genome Curation Page Haploinsufficency Little evidence for dosage pathogenicity (Last evaluated 2023-01-25) ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat induces CAK2B Thr-287 phosphorylation in mature and immature oligodendrocytes in vitro	PubMed
	tat	HIV-1 Tat activates CAMK2B in both mature and immature oligodendrocytes in vitro	PubMed
	tat	Tat-induced IL-10 expression is regulated by p38 MAPK- and CaMK II-activated CREB-1 as well as Sp-1 transcription factors	PubMed
	tat	HIV-1 Tat inhibits the activation of CAMKII elicited via LFA-1 in NK cells, providing evidence that Tat inhibits NK cell activation which might contribute to the impairment of natural immunity in HIV-1 infection	PubMed
	tat	HIV-1 Tat inhibits the activation of CAMKII elicited via beta (3) integrin	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7S2140E (e-PCR)
- UniSTS:55574

SHGC-32552 (e-PCR)
- UniSTS:2599

SHGC-79851 (e-PCR)
- UniSTS:101426

SHGC-172651 (e-PCR)
- UniSTS:184632

D7S2630 (e-PCR)
- UniSTS:21580

GDB:1318018 (e-PCR)
- UniSTS:61935

SHGC-147284 (e-PCR)
- UniSTS:172785

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables calcium/calmodulin-dependent protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium/calmodulin-dependent protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendritic spine morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of synapse maturation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of calcium ion transport	TAS Traceable Author Statement more info	PubMed
involved_in regulation of dendritic spine development	TAS Traceable Author Statement more info	PubMed
involved_in regulation of long-term neuronal synaptic plasticity	TAS Traceable Author Statement more info	PubMed
involved_in regulation of neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuronal synaptic plasticity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of skeletal muscle adaptation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of synapse structural plasticity	TAS Traceable Author Statement more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of calcium- and calmodulin-dependent protein kinase complex	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in endocytic vesicle membrane	TAS Traceable Author Statement more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: calcium/calmodulin-dependent protein kinase type II subunit beta

Names: CaM kinase II beta subunit; CaM-kinase II beta chain; caMK-II subunit beta; proline rich calmodulin-dependent protein kinase

NP_001211.3

EC 2.7.11.17

NP_001280099.1

EC 2.7.11.17

NP_742075.1

EC 2.7.11.17

NP_742076.1

EC 2.7.11.17

NP_742077.1

EC 2.7.11.17

NP_742078.1

EC 2.7.11.17

NP_742079.1

EC 2.7.11.17

NP_742080.1

EC 2.7.11.17

NP_742081.1

EC 2.7.11.17

XP_005249919.1

EC 2.7.11.17

XP_005249921.1

EC 2.7.11.17

XP_006715844.1

EC 2.7.11.17

XP_006715847.1

EC 2.7.11.17

XP_011513849.1

EC 2.7.11.17

XP_011513851.1

EC 2.7.11.17

XP_011513852.1

EC 2.7.11.17

XP_011513853.1

EC 2.7.11.17

XP_011513854.1

EC 2.7.11.17

XP_011513855.1

EC 2.7.11.17

XP_011513856.1

EC 2.7.11.17

XP_011513857.1

EC 2.7.11.17

XP_011513858.1

EC 2.7.11.17

XP_011513859.1

EC 2.7.11.17

XP_011513860.1

EC 2.7.11.17

XP_011513861.1

EC 2.7.11.17

XP_016868149.1

EC 2.7.11.17

XP_016868150.1

EC 2.7.11.17

XP_016868151.1

EC 2.7.11.17

XP_016868153.1

EC 2.7.11.17

XP_016868154.1

EC 2.7.11.17

XP_024302713.1

EC 2.7.11.17

XP_047276836.1

EC 2.7.11.17

XP_047276837.1

EC 2.7.11.17

XP_047276838.1

EC 2.7.11.17

XP_047276839.1

EC 2.7.11.17

XP_054215063.1

EC 2.7.11.17

XP_054215064.1

EC 2.7.11.17

XP_054215065.1

EC 2.7.11.17

XP_054215066.1

EC 2.7.11.17

XP_054215067.1

EC 2.7.11.17

XP_054215068.1

EC 2.7.11.17

XP_054215069.1

EC 2.7.11.17

XP_054215070.1

EC 2.7.11.17

XP_054215071.1

EC 2.7.11.17

XP_054215072.1

EC 2.7.11.17

XP_054215073.1

EC 2.7.11.17

XP_054215074.1

EC 2.7.11.17

XP_054215075.1

EC 2.7.11.17

XP_054215076.1

EC 2.7.11.17

XP_054215077.1

EC 2.7.11.17

XP_054215078.1

EC 2.7.11.17

XP_054215079.1

EC 2.7.11.17

XP_054215080.1

EC 2.7.11.17

XP_054215081.1

EC 2.7.11.17

XP_054215082.1

EC 2.7.11.17

XP_054215083.1

EC 2.7.11.17

XP_054215084.1

EC 2.7.11.17

XP_054215085.1

EC 2.7.11.17

XP_054215086.1

EC 2.7.11.17

XP_054215087.1

EC 2.7.11.17

XP_054215088.1

EC 2.7.11.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029407.1 RefSeqGene

Range

5038..113478

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001220.5 → NP_001211.3 calcium/calmodulin-dependent protein kinase type II subunit beta isoform 1

See identical proteins and their annotated locations for NP_001211.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC006454, AK290148, BI550751, U23460

Consensus CDS

CCDS5483.1

UniProtKB/Swiss-Prot

A4D2K0, A4D2K1, A4D2K2, A4D2K3, A4D2K4, A4D2K5, A4D2K6, O95437, O95438, O95599, Q13554, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4

UniProtKB/TrEMBL

A0A8V8TQ39, A4D2J9

Related

ENSP00000379098.2, ENST00000395749.7

Conserved Domains (2) summary

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:534 → 661

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
NM_001293170.2 → NP_001280099.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform 2

See identical proteins and their annotated locations for NP_001280099.1

Status: REVIEWED

Description

Transcript Variant: This variant (9) lacks multiple alternate in-frame exons in the 3' coding region and differs in the 3' UTR, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1. Variants 2 and 9 encode the same protein (isoform 2).

Source sequence(s)

AF078803, AK290148, AK294138, BI550751, BQ130578

Consensus CDS

CCDS5484.1

UniProtKB/TrEMBL

Q53H78

Related

ENSP00000326375.5, ENST00000350811.7

Conserved Domains (2) summary

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:410 → 537

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
NM_172078.3 → NP_742075.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform 2

See identical proteins and their annotated locations for NP_742075.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (2) that is missing an internal segment compared to isoform 1. Variants 2 and 9 encode the same protein (isoform 2).

Source sequence(s)

AC006454, AF078803, AK290148, BI550751

Consensus CDS

CCDS5484.1

UniProtKB/TrEMBL

Q53H78

Related

ENSP00000397937.2, ENST00000440254.6

Conserved Domains (2) summary

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:410 → 537

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
NM_172079.3 → NP_742076.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform 3

See identical proteins and their annotated locations for NP_742076.1

Status: REVIEWED

Description

Transcript Variant: This variant (3), also known as beta 4, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (3), also known as beta 4 subunit, that is missing an internal segment compared to isoform 1.

Source sequence(s)

AC006454, AJ252238, AK290148, BI550751, BX445032, DB566810

Consensus CDS

CCDS5485.1

UniProtKB/TrEMBL

Q53H78

Related

ENSP00000379096.2, ENST00000395747.6

Conserved Domains (2) summary

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:386 → 513

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
NM_172080.3 → NP_742077.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform 4

See identical proteins and their annotated locations for NP_742077.1

Status: REVIEWED

Description

Transcript Variant: This variant (4), also known as beta e, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (4), also known as beta e subunit, that is missing an internal segment compared to isoform 1.

Source sequence(s)

AC006454, AF083419, AK290148, BI550751

Consensus CDS

CCDS43573.1

UniProtKB/TrEMBL

Q53H78

Related

ENSP00000258682.6, ENST00000258682.10

Conserved Domains (2) summary

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:385 → 512

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
NM_172081.3 → NP_742078.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform 5

See identical proteins and their annotated locations for NP_742078.1

Status: REVIEWED

Description

Transcript Variant: This variant (5), also known as beta e', lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (5), also known as beta e' subunit, that is missing an internal segment compared to isoform 1.

Source sequence(s)

AC006454, AK290148, BC019070

Consensus CDS

CCDS5486.1

UniProtKB/TrEMBL

Q53H78

Related

ENSP00000351542.3, ENST00000358707.7

Conserved Domains (2) summary

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:371 → 498

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
NM_172082.3 → NP_742079.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform 6

See identical proteins and their annotated locations for NP_742079.1

Status: REVIEWED

Description

Transcript Variant: This variant (6), also known as beta 6, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (6), also known as beta 6 subunit, that is missing an internal segment compared to isoform 1.

Source sequence(s)

AC006454, AF081924, AK290148, BI550751

Consensus CDS

CCDS5487.1

UniProtKB/TrEMBL

A0A8V8TR22

Related

ENSP00000326544.6, ENST00000347193.8

Conserved Domains (2) summary

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

cl09109
Location:386 → 487

NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
NM_172083.3 → NP_742080.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform 7

See identical proteins and their annotated locations for NP_742080.1

Status: REVIEWED

Description

Transcript Variant: This variant (7), also known as beta 2, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (7), also known as beta 2 subunit, that is missing an internal segment compared to isoform 1.

Source sequence(s)

AA399393, AC006454, AJ252236, AK290148, BI550751, DA069361, DB175099

Consensus CDS

CCDS5488.1

UniProtKB/TrEMBL

Q53H78

Related

ENSP00000326427.5, ENST00000353625.8

Conserved Domains (2) summary

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:347 → 474

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
NM_172084.3 → NP_742081.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform 8

See identical proteins and their annotated locations for NP_742081.1

Status: REVIEWED

Description

Transcript Variant: This variant (8), also known as beta 7, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (8), also known as beta 7 subunit, that is missing an internal segment compared to isoform 1.

Source sequence(s)

AC006454, AK290148, BI550751, BX445032, DB566810

Consensus CDS

CCDS5489.1

UniProtKB/TrEMBL

Q53H78

Related

ENSP00000326518.5, ENST00000346990.8

Conserved Domains (2) summary

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:317 → 444

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

44217154..44326013 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011515559.3 → XP_011513861.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X19

See identical proteins and their annotated locations for XP_011513861.1

Conserved Domains (3) summary

smart00220
Location:1 → 143

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam08332
Location:448 → 575

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

cl21453
Location:1 → 174

PKc_like; Protein Kinases, catalytic domain
XM_017012665.2 → XP_016868154.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X24

UniProtKB/TrEMBL

Q53H78

Conserved Domains (2) summary

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:361 → 488

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_011515557.2 → XP_011513859.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X11

UniProtKB/TrEMBL

A0A8V8TQR5

Conserved Domains (3) summary

smart00220
Location:14 → 272

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:528 → 655

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_017012664.2 → XP_016868153.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X22

UniProtKB/TrEMBL

Q53H78

Conserved Domains (2) summary

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:370 → 497

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_006715781.3 → XP_006715844.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X26

UniProtKB/TrEMBL

A0A8V8TQR5

Conserved Domains (3) summary

smart00220
Location:14 → 272

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:494 → 621

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_011515554.2 → XP_011513856.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X8

Conserved Domains (3) summary

smart00220
Location:14 → 272

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:537 → 664

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_017012662.2 → XP_016868151.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X17

UniProtKB/TrEMBL

A0A8V8TQR5
XM_011515552.2 → XP_011513854.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X5

Conserved Domains (3) summary

smart00220
Location:14 → 272

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:552 → 679

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_005249864.4 → XP_005249921.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X23

See identical proteins and their annotated locations for XP_005249921.1

UniProtKB/TrEMBL

Q53H78

Conserved Domains (2) summary

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:362 → 489

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_011515556.2 → XP_011513858.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X10

UniProtKB/TrEMBL

A0A8V8TQR5

Conserved Domains (3) summary

smart00220
Location:14 → 272

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:529 → 656

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_047420882.1 → XP_047276838.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X18
XM_047420881.1 → XP_047276837.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X15
XM_017012660.2 → XP_016868149.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X7
XM_047420880.1 → XP_047276836.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X13
XM_011515550.2 → XP_011513852.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X3

Conserved Domains (3) summary

smart00220
Location:14 → 272

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:553 → 680

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_006715784.3 → XP_006715847.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X21

See identical proteins and their annotated locations for XP_006715847.1

UniProtKB/TrEMBL

Q53H78

Conserved Domains (2) summary

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:386 → 513

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_011515551.2 → XP_011513853.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X4

UniProtKB/TrEMBL

A0A8V8TQR5

Conserved Domains (3) summary

smart00220
Location:14 → 272

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:553 → 680

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_005249862.4 → XP_005249919.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X20

See identical proteins and their annotated locations for XP_005249919.1

UniProtKB/TrEMBL

Q53H78

Conserved Domains (2) summary

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:395 → 522

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_017012661.2 → XP_016868150.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X12

UniProtKB/TrEMBL

A0A8V8TQR5
XM_011515549.2 → XP_011513851.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X2

Conserved Domains (3) summary

smart00220
Location:14 → 272

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:562 → 689

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_024446945.2 → XP_024302713.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X14

UniProtKB/TrEMBL

A0A8V8TQR5

Conserved Domains (2) summary

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:496 → 623

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_011515553.2 → XP_011513855.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X6

UniProtKB/TrEMBL

A0A8V8TQR5

Conserved Domains (3) summary

smart00220
Location:14 → 272

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:539 → 666

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_011515555.2 → XP_011513857.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X9

UniProtKB/TrEMBL

A0A8V8TQ39

Conserved Domains (3) summary

smart00220
Location:14 → 272

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:534 → 661

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_011515547.2 → XP_011513849.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1

See identical proteins and their annotated locations for XP_011513849.1

Conserved Domains (3) summary

smart00220
Location:14 → 272

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:577 → 704

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
XM_047420883.1 → XP_047276839.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X25

Related

ENSP00000514922.1, ENST00000700291.1
XM_011515558.3 → XP_011513860.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X16

Conserved Domains (2) summary

smart00220
Location:14 → 272

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14086
Location:12 → 303

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

Alternate T2T-CHM13v2.0

Genomic

NC_060931.1 Alternate T2T-CHM13v2.0

Range

44375741..44485432 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054359106.1 → XP_054215081.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X19
XM_054359111.1 → XP_054215086.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X24
XM_054359098.1 → XP_054215073.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X11
XM_054359109.1 → XP_054215084.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X22
XM_054359113.1 → XP_054215088.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X26
XM_054359095.1 → XP_054215070.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X8
XM_054359104.1 → XP_054215079.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X17
XM_054359092.1 → XP_054215067.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X5
XM_054359110.1 → XP_054215085.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X23
XM_054359097.1 → XP_054215072.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X10
XM_054359105.1 → XP_054215080.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X18
XM_054359102.1 → XP_054215077.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X15
XM_054359094.1 → XP_054215069.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X7
XM_054359100.1 → XP_054215075.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X13
XM_054359090.1 → XP_054215065.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X3
XM_054359108.1 → XP_054215083.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X21
XM_054359091.1 → XP_054215066.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X4
XM_054359107.1 → XP_054215082.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X20
XM_054359099.1 → XP_054215074.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X12
XM_054359089.1 → XP_054215064.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X2
XM_054359101.1 → XP_054215076.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X14
XM_054359093.1 → XP_054215068.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X6
XM_054359096.1 → XP_054215071.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X9
XM_054359088.1 → XP_054215063.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1
XM_054359112.1 → XP_054215087.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X25
XM_054359103.1 → XP_054215078.1 calcium/calmodulin-dependent protein kinase type II subunit beta isoform X16