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Amd1 adenosylmethionine decarboxylase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81640, updated on 10-Jul-2024

Summary

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Official Symbol
Amd1provided by RGD
Official Full Name
adenosylmethionine decarboxylase 1provided by RGD
Primary source
RGD:2104
See related
EnsemblRapid:ENSRNOG00000000585 AllianceGenome:RGD:2104
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Amd1a; Amd1b
Summary
Enables adenosylmethionine decarboxylase activity and putrescine binding activity. Involved in S-adenosylmethionine metabolic process; spermidine biosynthetic process; and spermine biosynthetic process. Located in cytosol. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human AMD1 (adenosylmethionine decarboxylase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 374.7), Kidney (RPKM 362.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Amd1 in Genome Data Viewer
Location:
20q12
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (45250289..45324939, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (43695783..43711476, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (45384000..45399694, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U3 Neighboring gene uncharacterized LOC120098816 Neighboring gene vasculin-like protein 1 Neighboring gene transmembrane protein 258, pseudogene 3 Neighboring gene U6 spliceosomal RNA Neighboring gene cyclin-dependent kinase 19 Neighboring gene solute carrier family 22 member 16

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Dysregulated gene expression predicts tumor aggressiveness in African-American prostate cancer patients. Ali HEA, et al. Sci Rep, 2018 Nov 5. PMID 30397274, Free PMC Article
  2. Conformational stabilization of rat s-adenosylmethionine decarboxylase by putrescine. Wada M, et al. Biol Pharm Bull, 2010. PMID 21048303
  3. Polyamine depletion delays apoptosis of rat intestinal epithelial cells. Ray RM, et al. Am J Physiol Cell Physiol, 2000 Mar. PMID 10712236
  4. Structures and chromosomal localizations of two rat genes encoding S-adenosylmethionine decarboxylase. Pulkka A, et al. Genomics, 1993 May. PMID 8314573
  5. Structure and organization of the gene encoding rat S-adenosylmethionine decarboxylase. Pulkka A, et al. FEBS Lett, 1991 Oct 21. PMID 1936275

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables adenosylmethionine decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenosylmethionine decarboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables adenosylmethionine decarboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables putrescine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables putrescine binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in S-adenosylmethionine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in polyamine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in spermidine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermidine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in spermidine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in spermidine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in spermine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in spermine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
S-adenosylmethionine decarboxylase proenzyme
Names
S-Adenosylmethionine decarboxylase 1B
S-adenosylmethionine decarboxylase 1
S-adenosylmethionine decarboxylase 1A
SAMDC
adoMetDC
NP_112273.3
XP_063135627.1
XP_063135628.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031011.4 → NP_112273.3  S-adenosylmethionine decarboxylase proenzyme

    See identical proteins and their annotated locations for NP_112273.3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/Swiss-Prot
    P17708
    UniProtKB/TrEMBL
    A6KII8
    Related
    ENSRNOP00000105391.1, ENSRNOT00000137078.1
    Conserved Domains (1) summary
    pfam01536
    Location:4 → 325
    SAM_decarbox; Adenosylmethionine decarboxylase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    45250289..45324939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279557.1 → XP_063135627.1  S-adenosylmethionine decarboxylase proenzyme isoform X1

    UniProtKB/Swiss-Prot
    P17708
    UniProtKB/TrEMBL
    A6KII8

  2. XM_063279558.1 → XP_063135628.1  S-adenosylmethionine decarboxylase proenzyme isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17708.3 GenPept UniProtKB/Swiss-Prot:P17708

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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