U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abcc6 ATP binding cassette subfamily C member 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81642, updated on 10-Jul-2024

Summary

Go to the top of the page Help
Official Symbol
Abcc6provided by RGD
Official Full Name
ATP binding cassette subfamily C member 6provided by RGD
Primary source
RGD:620268
See related
EnsemblRapid:ENSRNOG00000028781 AllianceGenome:RGD:620268
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mrp6
Summary
Enables several functions, including ATP binding activity; ATP hydrolysis activity; and inorganic diphosphate transmembrane transporter activity. Involved in anion transport; cellular phosphate ion homeostasis; and xenobiotic transmembrane transport. Located in apical plasma membrane; basolateral plasma membrane; and lateral plasma membrane. Used to study pseudoxanthoma elasticum. Human ortholog(s) of this gene implicated in arterial calcification of infancy; coronary artery disease; and pseudoxanthoma elasticum. Orthologous to human ABCC6 (ATP binding cassette subfamily C member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 322.1) and Kidney (RPKM 51.1) See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Abcc6 in Genome Data Viewer
Location:
1q22
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (105583681..105637895, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (96447224..96501464, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101954786..102013252, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene epithelial membrane protein 3 Neighboring gene outer dynein arm docking complex subunit 1 Neighboring gene Nodal modulator 1 Neighboring gene natural killer cell cytotoxicity receptor 3 ligand 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Abcc6 Knockout Rat Model Highlights the Role of Liver in PPi Homeostasis in Pseudoxanthoma Elasticum. Li Q, et al. J Invest Dermatol, 2017 May. PMID 28111129, Free PMC Article
  2. Effect of inflammation on molecular targets and drug transporters. Hanafy S, et al. J Pharm Pharm Sci, 2012. PMID 22974786
  3. Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6). Belinsky MG, et al. Cancer Res, 2002 Nov 1. PMID 12414644
  4. Nucleotide binding and nucleotide hydrolysis properties of the ABC transporter MRP6 (ABCC6). Cai J, et al. Biochemistry, 2002 Jun 25. PMID 12069597
  5. A novel Q378X mutation exists in the transmembrane transporter protein ABCC6 and its pseudogene: implications for mutation analysis in pseudoxanthoma elasticum. Cai L, et al. J Mol Med (Berl), 2001 Sep. PMID 11692167

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study suggests a critical role of hepatic ABCC6 in contributing to plasma inorganic pyrophosphate levels, identifying liver as a target of molecular correction to counteract ectopic mineralization in pseudoxanthoma elasticum
    Title: Abcc6 Knockout Rat Model Highlights the Role of Liver in PPi Homeostasis in Pseudoxanthoma Elasticum.
  2. In a rat model of CKD, ABCC6 protein expression was decreased in liver and kidney, however mRNA levels were unchanged.
    Title: Chronic kidney disease results in deficiency of ABCC6, the novel inhibitor of vascular calcification.
  3. In the absence of transfected rat ABCC6, HeLa and HEK293 cells released almost no ATP, but on induction of rat ABCC6, they released substantial amounts of ATP into the cell culture medium.
    Title: ABCC6-mediated ATP secretion by the liver is the main source of the mineralization inhibitor inorganic pyrophosphate in the systemic circulation-brief report.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ABC-type glutathione S-conjugate transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables ABC-type glutathione S-conjugate transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ABC-type xenobiotic transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase-coupled transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables inorganic diphosphate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in ATP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ATP transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ATP transport ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in inhibition of non-skeletal tissue mineralization ISO
Inferred from Sequence Orthology
more info
  
involved_in inorganic diphosphate transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in inorganic diphosphate transport ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular phosphate ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular phosphate ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in leukotriene transport ISO
Inferred from Sequence Orthology
more info
  
involved_in leukotriene transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphate ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in response to magnesium ion ISO
Inferred from Sequence Orthology
more info
  
involved_in response to sodium phosphate ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in xenobiotic transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in lateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ATP-binding cassette sub-family C member 6
Names
ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ATP-binding cassette, subfamily C (CFTR/MRP), member 6
MLP-1
MRP-like protein 1
liver multidrug resistance-associated protein 6
multidrug resistance-associated protein 6
NP_112275.1
XP_017445259.1
XP_038948021.1
XP_038948028.1
XP_038948044.1
XP_063131205.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031013.1 → NP_112275.1  ATP-binding cassette sub-family C member 6

    See identical proteins and their annotated locations for NP_112275.1

    Status: PROVISIONAL

    Source sequence(s)
    U73038
    UniProtKB/Swiss-Prot
    O88269
    UniProtKB/TrEMBL
    A6JBA8
    Related
    ENSRNOP00000051412.1, ENSRNOT00000042115.3
    Conserved Domains (4) summary
    TIGR00957
    Location:36 → 1501
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:1262 → 1482
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:627 → 828
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    cl00549
    Location:950 → 1215
    ABC_membrane; ABC transporter transmembrane region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    105583681..105637895 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092100.2 → XP_038948028.1  ATP-binding cassette sub-family C member 6 isoform X2

    UniProtKB/TrEMBL
    A6JBA8
    Conserved Domains (1) summary
    TIGR00957
    Location:4 → 1398
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)

  2. XM_039092093.2 → XP_038948021.1  ATP-binding cassette sub-family C member 6 isoform X1

    UniProtKB/TrEMBL
    A6JBA8
    Conserved Domains (1) summary
    TIGR00957
    Location:36 → 1414
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)

  3. XM_063275135.1 → XP_063131205.1  ATP-binding cassette sub-family C member 6 isoform X3

    UniProtKB/TrEMBL
    A6JBA8

  4. XM_017589770.3 → XP_017445259.1  ATP-binding cassette sub-family C member 6 isoform X3

    UniProtKB/TrEMBL
    A6JBA8

  5. XM_039092116.2 → XP_038948044.1  ATP-binding cassette sub-family C member 6 isoform X4

    Conserved Domains (1) summary
    TIGR00957
    Location:25 → 894
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88269.1 GenPept UniProtKB/Swiss-Prot:O88269

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous