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C6orf62 chromosome 6 open reading frame 62 [ Homo sapiens (human) ]

Gene ID: 81688, updated on 3-Apr-2024

Summary

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Official Symbol
C6orf62provided by HGNC
Official Full Name
chromosome 6 open reading frame 62provided by HGNC
Primary source
HGNC:HGNC:20998
See related
Ensembl:ENSG00000112308 AllianceGenome:HGNC:20998
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
XTP12; dJ30M3.2; Nbla00237
Expression
Ubiquitous expression in testis (RPKM 42.5), spleen (RPKM 41.6) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
6p22.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (24704861..24720836, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (24575985..24592053, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (24705089..24719382, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901279 Neighboring gene acyl-CoA thioesterase 13 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:24682160-24682927 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:24682928-24683696 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr6:24683697-24684463 Neighboring gene uncharacterized LOC124901278 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:24699525-24699689 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:24720063-24720856 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:24721651-24722444 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24157 Neighboring gene long intergenic non-protein coding RNA 2828 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:24754099-24754309 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:24758062-24758263 Neighboring gene AP3S1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24158 Neighboring gene geminin DNA replication inhibitor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. Simpson JC, et al. EMBO Rep, 2000 Sep. PMID 11256614, Free PMC Article
  2. The DNA sequence and analysis of human chromosome 6. Mungall AJ, et al. Nature, 2003 Oct 23. PMID 14574404
  3. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. Wiemann S, et al. Genome Res, 2001 Mar. PMID 11230166, Free PMC Article
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article
  5. A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ12619, DKFZp564G182

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  

General protein information

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Preferred Names
uncharacterized protein C6orf62
Names
HBV X-transactivated gene 12 protein
HBV X-transactivated protein 12
HBV XAg-transactivated protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410835.1 → NP_001397764.1  uncharacterized protein C6orf62 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL031775, AL133264
    Consensus CDS
    CCDS93869.1
    Related
    ENSP00000367342.3, ENST00000378102.3

  2. NM_030939.5 → NP_112201.1  uncharacterized protein C6orf62 isoform 1

    See identical proteins and their annotated locations for NP_112201.1

    Status: VALIDATED

    Source sequence(s)
    AL133264, BC040260, BC047866
    Consensus CDS
    CCDS4559.1
    UniProtKB/Swiss-Prot
    Q3LIB6, Q5JVZ2, Q5JVZ3, Q6IA63, Q9GZU0, Q9H1Z2
    Related
    ENSP00000367359.4, ENST00000378119.9
    Conserved Domains (1) summary
    pfam15130
    Location:1 → 226
    DUF4566; Domain of unknown function (DUF4566)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    24704861..24720836 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419384.1 → XP_047275340.1  uncharacterized protein C6orf62 isoform X2

  2. XM_005249433.5 → XP_005249490.1  uncharacterized protein C6orf62 isoform X1

    Conserved Domains (1) summary
    pfam15130
    Location:1 → 143
    DUF4566; Domain of unknown function (DUF4566)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    24575985..24592053 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356494.1 → XP_054212469.1  uncharacterized protein C6orf62 isoform X1

  2. XM_054356495.1 → XP_054212470.1  uncharacterized protein C6orf62 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9GZU0.1 GenPept UniProtKB/Swiss-Prot:Q9GZU0

Gene LinkOut

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