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Nell1 neural EGFL like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81733, updated on 2-Nov-2024

Summary

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Official Symbol
Nell1provided by RGD
Official Full Name
neural EGFL like 1provided by RGD
Primary source
RGD:620998
See related
EnsemblRapid:ENSRNOG00000015675 AllianceGenome:RGD:620998
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables heparin binding activity; identical protein binding activity; and protein kinase C binding activity. Involved in positive regulation of apoptotic process; positive regulation of ossification; and regulation of osteoblast differentiation. Located in extracellular space. Used to study craniosynostosis. Orthologous to human NELL1 (neural EGFL like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 158.3), Lung (RPKM 60.4) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Nell1 in Genome Data Viewer
Location:
1q22
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (108845462..109709858)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (99709305..100573872)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (105348577..106218970)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 53 Neighboring gene solute carrier family 6 member 5 Neighboring gene uncharacterized LOC120097222 Neighboring gene 60S ribosomal protein L31-like Neighboring gene RIKEN cDNA 4933405O20 gene like Neighboring gene NSA2 ribosome biogenesis factor, pseudogene 7 Neighboring gene transfer RNA alanine (anticodon AGC) 61 Neighboring gene ferritin light chain 1, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. NELL-1 injection maintains long-bone quantity and quality in an ovariectomy-induced osteoporotic senile rat model. Kwak J, et al. Tissue Eng Part A, 2013 Feb. PMID 23083222, Free PMC Article
  2. Nell-1 enhances bone regeneration in a rat critical-sized femoral segmental defect model. Li W, et al. Plast Reconstr Surg, 2011 Feb. PMID 21285762, Free PMC Article
  3. An ectopic study of tissue-engineered bone with Nell-1 gene modified rat bone marrow stromal cells in nude mice. Hu JZ, et al. Chin Med J (Engl), 2009 Apr 20. PMID 19493425
  4. Nell-1 induced bone formation within the distracted intermaxillary suture. Cowan CM, et al. Bone, 2006 Jan. PMID 16243593
  5. Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development. Zhang X, et al. J Bone Miner Res, 2003 Dec. PMID 14672347

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The expression levels of neural markers were increased in rat pulp and in cultured human dental pulp stem cells stimulated with Nell-1 protein. This is the first study to demonstrate the effect of Nell-1 on dental pulp cells neural-like differentiation.
    Title: Nell-1 promotes the neural-like differentiation of dental pulp cells.
  2. These findings suggested that combined use of NELL-1 and BMP2 could positively regulate pulp repair.
    Title: Effects of Nel-like molecule-1 and bone morphogenetic protein 2 combination on rat pulp repair.
  3. establish the feasibility of combining NELL-1 with BMP2 to improve clinical bone regeneration and provide mechanistic insight into canonical Wnt pathway activity during NELL-1 and BMP2 osteogenesis
    Title: Novel Wnt Regulator NEL-Like Molecule-1 Antagonizes Adipogenesis and Augments Osteogenesis Induced by Bone Morphogenetic Protein 2.
  4. NELL-1570 has the potential to be used for cell-based or hormone-based therapy of bone regeneration.
    Title: Proliferation and osteogenic differentiation of mesenchymal stem cells induced by a short isoform of NELL-1.
  5. Thus, NELL-1 effectively enhances in situ osteogenesis in the bone marrow, making it potentially useful in the prevention and treatment of osteoporotic fractures.
    Title: NELL-1 injection maintains long-bone quantity and quality in an ovariectomy-induced osteoporotic senile rat model.
  6. Nell-1 can significantly improve bone regeneration in a femoral segmental defect in a dose-dependent manner and is a potent osteospecific growth factor.
    Title: Nell-1 enhances bone regeneration in a rat critical-sized femoral segmental defect model.
  7. Data show that Nell-1 overexpression induced calvarial overgrowth resulting in premature suture closure
    Title: Craniosynostosis in transgenic mice overexpressing Nell-1.
  8. Nell1 accelerates chondrocyte hypertrophy and endochondral bone formation.
    Title: Nell-1 induced bone formation within the distracted intermaxillary suture.
  9. Nell-1 overexpression disrupts these pathways resulting in craniofacial anomalies such as premature suture closure.
    Title: Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development.
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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heparin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase C binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase C binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of osteoblast proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of osteoblast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of bone mineralization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of ossification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of ossification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of osteoblast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
protein kinase C-binding protein NELL1
Names
NEL-like 1
NEL-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031069.3 → NP_112331.2  protein kinase C-binding protein NELL1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    A6JBG8, D4A284, Q62919
    Related
    ENSRNOP00000112278.1, ENSRNOT00000145487.1
    Conserved Domains (6) summary
    smart00179
    Location:549 → 586
    EGF_CA; Calcium-binding EGF-like domain
    smart00210
    Location:29 → 213
    TSPN; Thrombospondin N-terminal -like domains
    pfam07645
    Location:596 → 627
    EGF_CA; Calcium-binding EGF domain
    cl17735
    Location:273 → 331
    VWC; von Willebrand factor type C domain
    pfam12947
    Location:480 → 515
    EGF_3; EGF domain
    NF033759
    Location:386 → 556
    exchanger_TraA; outer membrane exchange protein TraA

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    108845462..109709858
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275221.1 → XP_063131291.1  protein kinase C-binding protein NELL1 isoform X3

  2. XM_063275215.1 → XP_063131285.1  protein kinase C-binding protein NELL1 isoform X2

  3. XM_017589771.3 → XP_017445260.1  protein kinase C-binding protein NELL1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A059
    Related
    ENSRNOP00000083529.1, ENSRNOT00000094328.2

  4. XM_039092192.2 → XP_038948120.1  protein kinase C-binding protein NELL1 isoform X4

    UniProtKB/TrEMBL
    A6JBG9
    Conserved Domains (3) summary
    smart00179
    Location:434 → 466
    EGF_CA; Calcium-binding EGF-like domain
    smart00210
    Location:29 → 213
    TSPN; Thrombospondin N-terminal -like domains
    pfam00093
    Location:273 → 331
    VWC; von Willebrand factor type C domain

  5. XM_039092195.2 → XP_038948123.1  protein kinase C-binding protein NELL1 isoform X5

    UniProtKB/TrEMBL
    A6JBG9
    Conserved Domains (2) summary
    smart00210
    Location:29 → 213
    TSPN; Thrombospondin N-terminal -like domains
    pfam00093
    Location:273 → 331
    VWC; von Willebrand factor type C domain

  6. XM_039092200.2 → XP_038948128.1  protein kinase C-binding protein NELL1 isoform X6

    UniProtKB/TrEMBL
    A6JBG9
    Conserved Domains (2) summary
    smart00210
    Location:29 → 213
    TSPN; Thrombospondin N-terminal -like domains
    pfam00093
    Location:273 → 331
    VWC; von Willebrand factor type C domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62919.3 GenPept UniProtKB/Swiss-Prot:Q62919

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