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Rnpep arginyl aminopeptidase [ Rattus norvegicus (Norway rat) ]

Gene ID: 81761, updated on 2-Nov-2024

Summary

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Official Symbol
Rnpepprovided by RGD
Official Full Name
arginyl aminopeptidaseprovided by RGD
Primary source
RGD:621137
See related
EnsemblRapid:ENSRNOG00000006720 AllianceGenome:RGD:621137
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables metalloaminopeptidase activity; peptide binding activity; and transition metal ion binding activity. Involved in negative regulation of blood pressure; protein processing; and retina development in camera-type eye. Located in external side of plasma membrane; extracellular space; and secretory granule. Used to study hypertension. Biomarker of hypertension. Orthologous to human RNPEP (arginyl aminopeptidase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 140.6), Testes (RPKM 139.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rnpep in Genome Data Viewer
Location:
13q13
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (49251259..49271440, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (46699458..46717829, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (52092863..52124006, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 37-like 1 Neighboring gene E74 like ETS transcription factor 3 Neighboring gene translocase of inner mitochondrial membrane 17A Neighboring gene uncharacterized LOC120096253 Neighboring gene leiomodin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Soluble and membrane-bound leucyl- and arginyl-aminopeptidase activities in subcellular fractions of young and adult rat brains. Ramírez M, et al. Rev Esp Fisiol, 1990 Dec. PMID 2099537
  2. Dysfunction of central angiotensinergic aminopeptidase activity in spontaneously hypertensive rats. Wright JW, et al. Neurosci Lett, 1985 Nov 11. PMID 3001599
  3. Developmental and ageing changes in aminopeptidase activities in selected tissues of the rat. Ramírez M, et al. Experientia, 1993 Apr 15. PMID 8477833
  4. Molecular cloning and expression of rat liver aminopeptidase B. Fukasawa KM, et al. J Biol Chem, 1996 Nov 29. PMID 8940051
  5. Aminopeptidase B from the rat testis is a bifunctional enzyme structurally related to leukotriene-A4 hydrolase. Cadel S, et al. Proc Natl Acad Sci U S A, 1997 Apr 1. PMID 9096329, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A structural analysis using circular dichroism, fluorescence spectroscopy, molecular modelling and dynamics was performed to investigate the role that residue G(298) plays in the catalytic mechanism of Ap-B
    Title: Mutation in the substrate-binding site of aminopeptidase B confers new enzymatic properties.
  2. Results suggest that the upregulation of serotonergic activity may be related to a lowered brain dipeptidyl peptidase III, alanyl- and arginyl aminopeptidase activity which may have an influence on the cleavage of their physiological substrates.
    Title: Central aminopeptidase and serotonin system activities: possible relationship.
  3. Zinc regulation demonstrates the metallopeptidase property of AP-B.
    Title: Zinc regulation of aminopeptidase B involved in neuropeptide production.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aminopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cobalt ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables copper ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metalloaminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloaminopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein processing NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IC
Inferred by Curator
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in retina development in camera-type eye IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus NAS
Non-traceable Author Statement
more info
 PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in secretory granule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
aminopeptidase B
Names
AP-B
arginine aminopeptidase
cytosol aminopeptidase IV
NP_112359.2
XP_063128706.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429661.1 → NP_001416590.1  aminopeptidase B isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A8I6GJU0

  2. NM_031097.2 → NP_112359.2  aminopeptidase B isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A6ICE6, G3V6V1, Q6P7D2
    Related
    ENSRNOP00000009198.3, ENSRNOT00000009198.7
    Conserved Domains (2) summary
    cd09599
    Location:24 → 484
    M1_LTA4H; Peptidase M1 family including Leukotriene A4 hydrolase catalytic domain
    pfam09127
    Location:530 → 645
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    49251259..49271440 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272636.1 → XP_063128706.1  aminopeptidase B isoform X1

    UniProtKB/TrEMBL
    A6ICE6, G3V6V1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O09175.2 GenPept UniProtKB/Swiss-Prot:O09175

Gene LinkOut

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