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COP1 Transducin/WD40 repeat-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 817857, updated on 18-Sep-2024

Summary

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Official Symbol
COP1
Official Full Name
Transducin/WD40 repeat-like superfamily protein
Primary source
TAIR:AT2G32950
Locus tag
AT2G32950
See related
Araport:AT2G32950
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS THALIANA CONSTITUTIVE PHOTOMORPHOGENIC 1; ATCOP1; CONSTITUTIVE PHOTOMORPHOGENIC 1; DEETIOLATED MUTANT 340; DET340; EMB168; EMBRYO DEFECTIVE 168; FUS1; FUSCA 1; T21L14.11; T21L14_11
Summary
Represses photomorphogenesis and induces skotomorphogenesis in the dark. Contains a ring finger zinc-binding motif, a coiled-coil domain, and several WD-40 repeats, similar to G-beta proteins. The C-terminus has homology to TAFII80, a subunit of the TFIID component of the RNA polymerase II of Drosophila. Nuclear localization in the dark and cytoplasmic in the light.
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Genomic context

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See COP1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
13
Sequence:
Chromosome: 2; NC_003071.7 (13977881..13983609)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene zinc finger nuclease 2 Neighboring gene Argonaute family protein Neighboring gene Phosphotyrosine protein phosphatases superfamily protein Neighboring gene G1/S-specific cyclin-E protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CONSTITUTIVELY PHOTOMORPHOGENIC1 promotes ABA-mediated inhibition of post-germination seedling establishment. Yadukrishnan P, et al. Plant J, 2020 Jul. PMID 32436306
  2. Modular domain structure of Arabidopsis COP1. Reconstitution of activity by fragment complementation and mutational analysis of a nuclear localization signal in planta. Stacey MG, et al. Plant Physiol, 2000 Nov. PMID 11080276, Free PMC Article
  3. COP1 jointly modulates cytoskeletal processes and electrophysiological responses required for stomatal closure. Khanna R, et al. Mol Plant, 2014 Sep. PMID 25151660, Free PMC Article
  4. COP1 plays a prominent role in drought stress tolerance in Arabidopsis and Pea. Moazzam-Jazi M, et al. Plant Physiol Biochem, 2018 Sep. PMID 30139551
  5. Imaging protein interactions with bioluminescence resonance energy transfer (BRET) in plant and mammalian cells and tissues. Xu X, et al. Proc Natl Acad Sci U S A, 2007 Jun 12. PMID 17551013, Free PMC Article

See all (175) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. S-nitrosylation may inhibit the activity of COP1 in plant photomorphogenesis.
    Title: S-nitrosylation may inhibit the activity of COP1 in plant photomorphogenesis.
  2. COP1-ERF1-SCE1 regulatory module fine-tunes stress response under light-dark cycle in Arabidopsis.
    Title: COP1-ERF1-SCE1 regulatory module fine-tunes stress response under light-dark cycle in Arabidopsis.
  3. Arabidopsis COP1 guides stomatal response in guard cells through pH regulation.
    Title: Arabidopsis COP1 guides stomatal response in guard cells through pH regulation.
  4. Dissecting the functions of COP1 in the UVR8 pathway with a COP1 variant in Arabidopsis.
    Title: Dissecting the functions of COP1 in the UVR8 pathway with a COP1 variant in Arabidopsis.
  5. CONSTITUTIVE PHOTOMORPHOGENIC 1 promotes seed germination by destabilizing RGA-LIKE 2 in Arabidopsis.
    Title: CONSTITUTIVE PHOTOMORPHOGENIC 1 promotes seed germination by destabilizing RGA-LIKE 2 in Arabidopsis.
  6. Functional comparison of the WD-repeat domains of SPA1 and COP1 in suppression of photomorphogenesis.
    Title: Functional comparison of the WD-repeat domains of SPA1 and COP1 in suppression of photomorphogenesis.
  7. DET1-mediated COP1 regulation avoids HY5 activity over second-site gene targets to tune plant photomorphogenesis.
    Title: DET1-mediated COP1 regulation avoids HY5 activity over second-site gene targets to tune plant photomorphogenesis.
  8. DET1 regulates HY5 through COP1: A new paradigm in the regulation of HY5.
    Title: DET1 regulates HY5 through COP1: A new paradigm in the regulation of HY5.
  9. Long-term abscisic acid promotes golden2-like1 degradation through constitutive photomorphogenic 1 in a light intensity-dependent manner to suppress chloroplast development.
    Title: Long-term abscisic acid promotes golden2-like1 degradation through constitutive photomorphogenic 1 in a light intensity-dependent manner to suppress chloroplast development.
  10. COP1 promotes ABA-induced stomatal closure by modulating the abundance of ABI/HAB and AHG3 phosphatases.
    Title: COP1 promotes ABA-induced stomatal closure by modulating the abundance of ABI/HAB and AHG3 phosphatases.
Submit: New GeneRIF Correction See all GeneRIFs (102)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

NM_001336418.1
NM_128855.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-protein transferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within anthocyanin-containing compound metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within entrainment of circadian clock IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within photomorphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within photomorphogenesis TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within photoperiodism, flowering IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of flavonoid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of stomatal movement IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of stomatal movement IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to UV-B IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within shade avoidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within skotomorphogenesis TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear ubiquitin ligase complex TAS
Traceable Author Statement
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Transducin/WD40 repeat-like superfamily protein
NP_180854.1
  • CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1); CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), Zinc finger, RING-type, conserved site (InterPro:IPR017907), Zinc finger, RING-type (InterPro:IPR001841), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), Zinc finger, C3HC4 RING-type (InterPro:IPR018957), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: SPA1-related 2 (TAIR:AT4G11110.1); Has 42218 Blast hits to 27649 proteins in 756 species: Archae - 30; Bacteria - 4454; Metazoa - 17716; Fungi - 8958; Plants - 5306; Viruses - 46; Other Eukaryotes - 5708 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    13977881..13983609
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_128855.4 → NP_180854.1  Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_180854.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O23974, O23975, O48770, P43254, Q1JPL6
    UniProtKB/TrEMBL
    A0A178VXE2, A0A5S9X3D9, A0A7G2EFX6
    Conserved Domains (3) summary
    PLN00181
    Location:148 → 671
    PLN00181; protein SPA1-RELATED; Provisional
    sd00039
    Location:375 → 418
    7WD40; WD40 repeat [structural motif]
    cd16504
    Location:48 → 93
    RING-HC_COP1; RING finger, HC subclass, found in constitutive photomorphogenesis protein 1 (COP1) and similar proteins

  2. NM_001336418.1 → NP_001325309.1  Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B2S1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43254.2

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