RIC1 ROP-interactive CRIB motif-containing protein 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: RIC1
Official Full Name: ROP-interactive CRIB motif-containing protein 1
Primary source: TAIR:AT2G33460
Locus tag: AT2G33460
See related: Araport:AT2G33460
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F4P9.23; F4P9_23; ROP-interactive CRIB motif-containing protein 1
Summary: encodes a member of a novel protein family that contains contain a CRIB (for Cdc42/Rac-interactive binding) motif required for their specific interaction with GTP-bound Rop1 (plant-specific Rho GTPase). Interacts with Rop1 and is involved in pollen tube growth and function. Protein most similar to RIC3(family subgroup III). RIC1 is localized to the apical region of the plasma membrane in pollen tube and mutation analyses indicate that this localization is dependent on ROP1 binding. Gene is expressed in all tissues examined.Analysis of overexpression and loss of function mutants indicates a role in cortical microtubule organization during pavement cell morphogenesis.
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See RIC1 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 5

Sequence:: Chromosome: 2; NC_003071.7 (14174144..14175965, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Smooth Elongation of Pavement Cells Induced by RIC1 Overexpression Leads to Marginal Protrusions of the Cotyledon in Arabidopsis thaliana.
Title: Smooth Elongation of Pavement Cells Induced by RIC1 Overexpression Leads to Marginal Protrusions of the Cotyledon in Arabidopsis thaliana.
ROP2-RIC1 pathway fine-tunes microtubule dynamics in response to salt stress in Arabidopsis.ROP2 participates in salt tolerance through suppressing RIC1.
Title: A ROP2-RIC1 pathway fine-tunes microtubule reorganization for salt tolerance in Arabidopsis.
Data indicate that the cellulase-induced inhibition of cell interdigitation was not observed in a RIC1 knockout mutant.
Title: Exogenous Cellulase Switches Cell Interdigitation to Cell Elongation in an RIC1-dependent Manner in Arabidopsis thaliana Cotyledon Pavement Cells.
Data propose that RIC1 regulates F-actin dynamics at the apical PM as well as the cytosol by severing F-actin and capping the barbed ends in the cytoplasm, establishing a novel mechanism that underlies the regulation of pollen tube growth.
Title: Arabidopsis RIC1 Severs Actin Filaments at the Apex to Regulate Pollen Tube Growth.
RIC1 knockout suppresses the effect of auxin on lateral root formation and primary root elongation.
Title: Arabidopsis ROP-interactive CRIB motif-containing protein 1 (RIC1) positively regulates auxin signalling and negatively regulates abscisic acid (ABA) signalling during root development.
The ROP6-RIC1 pathway links cytoplasmic auxin signaling to the regulation of cortical microtubule organization and cell elongation
Title: Rho GTPase signaling activates microtubule severing to promote microtubule ordering in Arabidopsis.
ROP6 and its downstream effector RIC1 regulate clathrin association with plasma membrane for clathrin-mediated endocytosis, as well as for its feedback regulation by auxin. Genetic analyses show ROP6/RIC1 acts downstream of ABP1 to regulate endocytosis.
Title: ABP1 and ROP6 GTPase signaling regulate clathrin-mediated endocytosis in Arabidopsis roots.
SPIKE1 (SPK1) mutations induced PIN2 internalization not suppressed by auxin, as did the loss-of-function mutations for Rho-like GTPase from Plants 6-GTPase or its effector RIC1. SPK1 was required for auxin induction of ROP6 activation.
Title: A ROP GTPase-dependent auxin signaling pathway regulates the subcellular distribution of PIN2 in Arabidopsis roots.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

NM_128906.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellulose microfibril organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cytoplasmic microtubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pollen tube growth	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cortical microtubule, transverse to long axis	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: ROP-interactive CRIB motif-containing protein 1

NP_180904.2

ROP-interactive CRIB motif-containing protein 1 (RIC1); FUNCTIONS IN: protein binding; INVOLVED IN: cell morphogenesis, pollen tube growth, cellulose microfibril organization, cytoplasmic microtubule organization; LOCATED IN: cortical microtubule, transverse to long axis, apical plasma membrane; EXPRESSED IN: 11 plant structures; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, 4 anthesis, C globular stage, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: PAK-box/P21-Rho-binding (InterPro:IPR000095); BEST Arabidopsis thaliana protein match is: ROP-interactive CRIB motif-containing protein 3 (TAIR:AT1G04450.1); Has 393 Blast hits to 355 proteins in 75 species: Archae - 0; Bacteria - 15; Metazoa - 105; Fungi - 14; Plants - 178; Viruses - 2; Other Eukaryotes - 79 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

14174144..14175965 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_128906.3 → NP_180904.2 ROP-interactive CRIB motif-containing protein 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_180904.2

Status: REVIEWED

UniProtKB/Swiss-Prot

F4IVV0, O22796

UniProtKB/TrEMBL

A0A178W0J9, A0A5S9X3I8, A0A654F943

Conserved Domains (2) summary

smart00285
Location:29 → 59

PBD; P21-Rho-binding domain

PHA03307
Location:100 → 209

PHA03307; transcriptional regulator ICP4; Provisional