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CAMK2G calcium/calmodulin dependent protein kinase II gamma [ Homo sapiens (human) ]

Gene ID: 818, updated on 3-Apr-2024

Summary

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Official Symbol
CAMK2Gprovided by HGNC
Official Full Name
calcium/calmodulin dependent protein kinase II gammaprovided by HGNC
Primary source
HGNC:HGNC:1463
See related
Ensembl:ENSG00000148660 MIM:602123; AllianceGenome:HGNC:1463
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAMK; CAMKG; MRD59; CAMK-II
Summary
The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Many alternatively spliced transcripts encoding different isoforms have been described but the full-length nature of all the variants has not been determined.[provided by RefSeq, Mar 2011]
Expression
Ubiquitous expression in brain (RPKM 28.7), prostate (RPKM 10.9) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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See CAMK2G in Genome Data Viewer
Location:
10q22.2
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (73812501..73874555, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (74683897..74745947, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (75572259..75634313, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene NDST2-ZSWIM8-AS1 readthrough Neighboring gene zinc finger SWIM-type containing 8 Neighboring gene ZSWIM8 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2489 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2490 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:75574449-75574702 Neighboring gene N-deacetylase and N-sulfotransferase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:75579102-75579602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:75579603-75580103 Neighboring gene MPRA-validated peak1013 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:75617818-75618318 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:75618319-75618819 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3577 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2491 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2493 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3578 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3579 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3580 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:75646944-75648143 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:75648172-75649130 Neighboring gene uncharacterized LOC124902454 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:75668366-75669565 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2495 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:75672789-75673988 Neighboring gene chromosome 10 putative open reading frame 55 Neighboring gene plasminogen activator, urokinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Ca(2+)/Calmodulin-Dependent Protein Kinase II Disrupts the Voltage Dependency of the Voltage-Dependent Anion Channel on the Lipid Bilayer Membrane. Koren DT, et al. J Phys Chem B, 2023 Apr 20. PMID 37040575
  2. CaMKIIγ regulates the viability and self-renewal of acute myeloid leukaemia stem-like cells by the Alox5/NF-κB pathway. Cheng JH, et al. Int J Lab Hematol, 2021 Aug. PMID 33369192
  3. CAMKIIγ is a targetable driver of multiple myeloma through CaMKIIγ/ Stat3 axis. Yang L, et al. Aging (Albany NY), 2020 Jul 13. PMID 32658867, Free PMC Article
  4. Subunit exchange enhances information retention by CaMKII in dendritic spines. Singh D, et al. Elife, 2018 Nov 12. PMID 30418153, Free PMC Article
  5. Organelle-Derived Acetyl-CoA Promotes Prostate Cancer Cell Survival, Migration, and Metastasis via Activation of Calmodulin Kinase II. Yu G, et al. Cancer Res, 2018 May 15. PMID 29535221, Free PMC Article

See all (207) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NETO2 promotes melanoma progression via activation of the Ca[2+]/CaMKII signaling pathway.
    Title: NETO2 promotes melanoma progression via activation of the Ca(2+)/CaMKII signaling pathway.
  2. Ca[2+]/Calmodulin-Dependent Protein Kinase II Disrupts the Voltage Dependency of the Voltage-Dependent Anion Channel on the Lipid Bilayer Membrane.
    Title: Ca(2+)/Calmodulin-Dependent Protein Kinase II Disrupts the Voltage Dependency of the Voltage-Dependent Anion Channel on the Lipid Bilayer Membrane.
  3. Impacts of altered exercise volume, intensity, and duration on the activation of AMPK and CaMKII and increases in PGC-1alpha mRNA.
    Title: Impacts of altered exercise volume, intensity, and duration on the activation of AMPK and CaMKII and increases in PGC-1α mRNA.
  4. CAMK2G is identified as a novel therapeutic target for myelofibrosis.
    Title: CAMK2G is identified as a novel therapeutic target for myelofibrosis.
  5. Matrine suppresses cell growth of diffuse large B-cell lymphoma via inhibiting CaMKIIgamma/c-Myc/CDK6 signaling pathway.
    Title: Matrine suppresses cell growth of diffuse large B-cell lymphoma via inhibiting CaMKIIγ/c-Myc/CDK6 signaling pathway.
  6. A physiologic rise in cytoplasmic calcium ion signal increases pannexin1 channel activity via a C-terminus phosphorylation by CaMKII.
    Title: A physiologic rise in cytoplasmic calcium ion signal increases pannexin1 channel activity via a C-terminus phosphorylation by CaMKII.
  7. CaMKIIgamma regulates the viability and self-renewal of acute myeloid leukaemia stem-like cells by the Alox5/NF-kappaB pathway.
    Title: CaMKIIγ regulates the viability and self-renewal of acute myeloid leukaemia stem-like cells by the Alox5/NF-κB pathway.
  8. CaMKII Phosphorylation Regulates Synaptic Enrichment of Shank3.
    Title: CaMKII Phosphorylation Regulates Synaptic Enrichment of Shank3.
  9. CaMK II/Ca2+ dependent endoplasmic reticulum stress mediates apoptosis of hepatic stellate cells stimulated by transforming growth factor beta 1.
    Title: CaMK II/Ca2+ dependent endoplasmic reticulum stress mediates apoptosis of hepatic stellate cells stimulated by transforming growth factor beta 1.
  10. CAMKIIgamma is a targetable driver of multiple myeloma through CaMKIIgamma/ Stat3 axis.
    Title: CAMKIIγ is a targetable driver of multiple myeloma through CaMKIIγ/ Stat3 axis.
Submit: New GeneRIF Correction See all GeneRIFs (74)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Intellectual developmental disorder 59
MedGen: C5193190 OMIM: 618522 GeneReviews: Not available
Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat The gene expression of calcium/calmodulin-dependent protein kinase II gamma is significantly upregulated in both clade B and clade C Tat treated SK-N-MC cells PubMed
tat HIV-1 Tat activates a CaMKII pathway at inhibitory synapses that leads to structural changes in GABARAP, resulting in increased membrane insertion of the gamma 2 subunit of GABAR PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ16043, MGC26678

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent protein serine/threonine phosphatase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in insulin secretion NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of calcium ion transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of skeletal muscle adaptation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of calcium- and calmodulin-dependent protein kinase complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endocytic vesicle membrane TAS
Traceable Author Statement
more info
  
located_in membrane HDA PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in sarcoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
calcium/calmodulin-dependent protein kinase type II subunit gamma
Names
caMK-II subunit gamma
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma
NP_001191421.1
NP_001213.2
NP_001307827.1
NP_001354443.1
NP_001354445.1
NP_001354446.1
NP_001354447.1
NP_001354448.1
NP_001354449.1
NP_001354450.1
NP_001354451.1
NP_001354452.1
NP_001354453.1
NP_001354454.1
NP_001354455.1
NP_001354456.1
NP_001354457.1
NP_001354458.1
NP_001354459.1
NP_001354460.1
NP_001354461.1
NP_001354462.1
NP_001354463.1
NP_001354464.1
NP_001354465.1
NP_001354466.1
NP_001354467.1
NP_001354468.1
NP_001354469.1
NP_001354470.1
NP_001354471.1
NP_001354472.1
NP_001354473.1
NP_001354474.1
NP_001354475.1
NP_001354476.1
NP_001354477.1
NP_751909.1
NP_751910.1
NP_751911.1
NP_751913.1
XP_005270255.1
XP_005270262.1
XP_006718059.1
XP_006718061.1
XP_016872219.1
XP_024303986.1
XP_047281753.1
XP_047281754.1
XP_047281755.1
XP_047281756.1
XP_047281757.1
XP_047281758.1
XP_047281759.1
XP_047281760.1
XP_047281761.1
XP_054222819.1
XP_054222820.1
XP_054222821.1
XP_054222822.1
XP_054222823.1
XP_054222824.1
XP_054222825.1
XP_054222826.1
XP_054222827.1
XP_054222828.1
XP_054222829.1
XP_054222830.1
XP_054222831.1
XP_054222832.1
XP_054222833.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029408.2 RefSeqGene

    Range
    5037..67091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001204492.2 → NP_001191421.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 7

    See identical proteins and their annotated locations for NP_001191421.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has an alternate in-frame exon and lacks an alternate in-frame exon compared to variant 1. The resulting protein (isoform 7) is shorter and lacks two internal segments compared to isoform 1.
    Source sequence(s)
    AC022400, AL596247, AL713896
    Consensus CDS
    CCDS73153.1
    UniProtKB/TrEMBL
    A8K6N9
    Related
    ENSP00000505103.1, ENST00000680035.1
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:407 → 534
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  2. NM_001222.4 → NP_001213.2  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 4

    See identical proteins and their annotated locations for NP_001213.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks in-frame segments of the coding region, compared to variant 1. It encodes a shorter isoform (4), that is missing internal segments compared to isoform 1.
    Source sequence(s)
    AC022400, AL596247, AL713896, L07043
    Consensus CDS
    CCDS7336.1
    UniProtKB/TrEMBL
    A8K6N9
    Related
    ENSP00000277853.5, ENST00000351293.7
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:363 → 490
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  3. NM_001320898.2 → NP_001307827.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC022400, AK131199, AK225771, AW295338, BC034044, DR002605
    UniProtKB/TrEMBL
    B3KY86
    Conserved Domains (3) summary
    smart00220
    Location:14 → 272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    cl09109
    Location:433 → 488
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...

  4. NM_001367514.1 → NP_001354443.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC022400, AK131199, AL596247
    UniProtKB/TrEMBL
    B3KY86

  5. NM_001367516.1 → NP_001354445.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    UniProtKB/TrEMBL
    A8K6N9
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:386 → 500
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  6. NM_001367517.1 → NP_001354446.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (50), as well as variant 3, encodes isoform 3.
    Source sequence(s)
    AC022400, AL596247, AL713896
    UniProtKB/TrEMBL
    A8K6N9
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:386 → 513
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  7. NM_001367518.1 → NP_001354447.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    UniProtKB/Swiss-Prot
    A0A0A0MS52, A0A0A0MT11, O00561, O15378, Q13279, Q13282, Q13555, Q13556, Q5SQZ3, Q5SQZ4, Q5SWX4, Q7KYX5, Q8N4I3, Q8NIA4
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:412 → 539
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  8. NM_001367519.1 → NP_001354448.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    UniProtKB/TrEMBL
    B3KY86

  9. NM_001367520.1 → NP_001354449.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    UniProtKB/TrEMBL
    B3KY86

  10. NM_001367521.1 → NP_001354450.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    UniProtKB/TrEMBL
    B3KY86

  11. NM_001367522.1 → NP_001354451.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    UniProtKB/TrEMBL
    B3KY86

  12. NM_001367523.1 → NP_001354452.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    UniProtKB/TrEMBL
    B3KY86

  13. NM_001367524.1 → NP_001354453.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    UniProtKB/TrEMBL
    B3KY86

  14. NM_001367525.1 → NP_001354454.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    UniProtKB/Swiss-Prot
    A0A0A0MS52, A0A0A0MT11, O00561, O15378, Q13279, Q13282, Q13555, Q13556, Q5SQZ3, Q5SQZ4, Q5SWX4, Q7KYX5, Q8N4I3, Q8NIA4
    Conserved Domains (2) summary
    cd14086
    Location:12 → 295
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:416 → 543
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  15. NM_001367526.1 → NP_001354455.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    Related
    ENST00000700397.1

  16. NM_001367527.1 → NP_001354456.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    UniProtKB/TrEMBL
    A0A8V8TQ60
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:422 → 549
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  17. NM_001367528.1 → NP_001354457.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    UniProtKB/TrEMBL
    B3KY86

  18. NM_001367529.1 → NP_001354458.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    UniProtKB/TrEMBL
    B3KY86

  19. NM_001367530.1 → NP_001354459.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    UniProtKB/TrEMBL
    A8K6N9
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:374 → 501
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  20. NM_001367531.1 → NP_001354460.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    Consensus CDS
    CCDS91267.1
    UniProtKB/TrEMBL
    A8K6N9
    Related
    ENSP00000307082.7, ENST00000305762.11
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:397 → 524
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  21. NM_001367532.1 → NP_001354461.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    UniProtKB/TrEMBL
    A8K6N9
    Conserved Domains (2) summary
    cd14086
    Location:12 → 295
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:378 → 505
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  22. NM_001367533.1 → NP_001354462.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 26

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    UniProtKB/Swiss-Prot
    A0A0A0MS52, A0A0A0MT11, O00561, O15378, Q13279, Q13282, Q13555, Q13556, Q5SQZ3, Q5SQZ4, Q5SWX4, Q7KYX5, Q8N4I3, Q8NIA4
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:410 → 537
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  23. NM_001367534.1 → NP_001354463.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    Consensus CDS
    CCDS91269.1
    UniProtKB/Swiss-Prot
    A0A0A0MS52, A0A0A0MT11, O00561, O15378, Q13279, Q13282, Q13555, Q13556, Q5SQZ3, Q5SQZ4, Q5SWX4, Q7KYX5, Q8N4I3, Q8NIA4
    UniProtKB/TrEMBL
    H0Y6G2
    Related
    ENSP00000410298.3, ENST00000423381.6
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:456 → 583
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  24. NM_001367535.1 → NP_001354464.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 28

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    Conserved Domains (1) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

  25. NM_001367536.1 → NP_001354465.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 29

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    UniProtKB/TrEMBL
    A8K6N9
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:403 → 530
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  26. NM_001367537.1 → NP_001354466.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 30

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247
    UniProtKB/TrEMBL
    Q8WU40

  27. NM_001367538.1 → NP_001354467.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 31

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247

  28. NM_001367539.1 → NP_001354468.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 32

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    UniProtKB/TrEMBL
    Q8WU40
    Conserved Domains (2) summary
    pfam08332
    Location:342 → 469
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:11 → 221
    PKc_like; Protein Kinases, catalytic domain

  29. NM_001367540.1 → NP_001354469.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 33

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896

  30. NM_001367541.1 → NP_001354470.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 34

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    UniProtKB/TrEMBL
    B3KY86

  31. NM_001367542.1 → NP_001354471.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 35

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    UniProtKB/TrEMBL
    A0A804CJ50
    Related
    ENSP00000378243.4, ENST00000394762.7
    Conserved Domains (2) summary
    pfam08332
    Location:194 → 321
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:1 → 52
    PKc_like; Protein Kinases, catalytic domain

  32. NM_001367543.1 → NP_001354472.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 36

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    UniProtKB/TrEMBL
    A8K6N9
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:418 → 545
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  33. NM_001367544.1 → NP_001354473.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 37

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    UniProtKB/Swiss-Prot
    A0A0A0MS52, A0A0A0MT11, O00561, O15378, Q13279, Q13282, Q13555, Q13556, Q5SQZ3, Q5SQZ4, Q5SWX4, Q7KYX5, Q8N4I3, Q8NIA4
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:445 → 572
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  34. NM_001367545.1 → NP_001354474.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 38

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    UniProtKB/Swiss-Prot
    A0A0A0MS52, A0A0A0MT11, O00561, O15378, Q13279, Q13282, Q13555, Q13556, Q5SQZ3, Q5SQZ4, Q5SWX4, Q7KYX5, Q8N4I3, Q8NIA4
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:401 → 528
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  35. NM_001367546.1 → NP_001354475.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 39

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    UniProtKB/TrEMBL
    A0A8V8TQ60
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:433 → 560
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  36. NM_001367547.1 → NP_001354476.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 40

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    UniProtKB/Swiss-Prot
    A0A0A0MS52, A0A0A0MT11, O00561, O15378, Q13279, Q13282, Q13555, Q13556, Q5SQZ3, Q5SQZ4, Q5SWX4, Q7KYX5, Q8N4I3, Q8NIA4
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:433 → 560
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  37. NM_001367548.1 → NP_001354477.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 41

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    UniProtKB/Swiss-Prot
    A0A0A0MS52, A0A0A0MT11, O00561, O15378, Q13279, Q13282, Q13555, Q13556, Q5SQZ3, Q5SQZ4, Q5SWX4, Q7KYX5, Q8N4I3, Q8NIA4

  38. NM_172169.3 → NP_751909.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 2

    See identical proteins and their annotated locations for NP_751909.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has multiple coding region differences, compared to variant 1. This results in a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AC022400, AL596247, BC034044
    Consensus CDS
    CCDS7337.1
    UniProtKB/TrEMBL
    A8K6N9
    Related
    ENSP00000315599.3, ENST00000322635.7
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:395 → 522
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  39. NM_172170.5 → NP_751910.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 3

    See identical proteins and their annotated locations for NP_751910.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (3), that is missing an internal segment compared to isoform 1. Variants 3 and 50 both encode the same isoform (3).
    Source sequence(s)
    AC022400, AL596247, AL713896
    UniProtKB/TrEMBL
    A8K6N9
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:386 → 513
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  40. NM_172171.3 → NP_751911.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 1

    See identical proteins and their annotated locations for NP_751911.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AC022400, AL596247, AL713896, U66063
    Consensus CDS
    CCDS7338.1
    UniProtKB/Swiss-Prot
    A0A0A0MS52, A0A0A0MT11, O00561, O15378, Q13279, Q13282, Q13555, Q13556, Q5SQZ3, Q5SQZ4, Q5SWX4, Q7KYX5, Q8N4I3, Q8NIA4
    UniProtKB/TrEMBL
    A0A2Q3DQE3
    Related
    ENSP00000319060.3, ENST00000322680.7
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:424 → 551
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  41. NM_172173.3 → NP_751913.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 6

    See identical proteins and their annotated locations for NP_751913.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks in-frame segments of the coding region, compared to variant 1. It encodes a shorter isoform (6), that is missing internal segments compared to isoform 1.
    Source sequence(s)
    AC022400, AL596247, AL713896, U50360
    UniProtKB/TrEMBL
    A8K6N9
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:372 → 499
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

RNA

  1. NR_160040.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896

  2. NR_160041.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896

  3. NR_160042.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896

  4. NR_160044.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896

  5. NR_160045.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896

  6. NR_160046.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896

  7. NR_160047.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896

  8. NR_160263.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022400, AK095576, AL596247

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    73812501..73874555 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425803.1 → XP_047281759.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X13

  2. XM_047425802.1 → XP_047281758.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X12

  3. XM_047425799.1 → XP_047281755.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X5

  4. XM_047425800.1 → XP_047281756.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X7

  5. XM_024448218.2 → XP_024303986.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X9

    UniProtKB/TrEMBL
    A0A8V8TPN2
    Conserved Domains (2) summary
    cd14086
    Location:12 → 295
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:387 → 514
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  6. XM_047425797.1 → XP_047281753.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1

  7. XM_017016730.2 → XP_016872219.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X11

    UniProtKB/TrEMBL
    A8K6N9
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:383 → 510
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  8. XM_006717996.2 → XP_006718059.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X2

    See identical proteins and their annotated locations for XP_006718059.1

    UniProtKB/Swiss-Prot
    A0A0A0MS52, A0A0A0MT11, O00561, O15378, Q13279, Q13282, Q13555, Q13556, Q5SQZ3, Q5SQZ4, Q5SWX4, Q7KYX5, Q8N4I3, Q8NIA4
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:435 → 562
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  9. XM_005270205.2 → XP_005270262.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X10

    See identical proteins and their annotated locations for XP_005270262.1

    UniProtKB/TrEMBL
    A8K6N9, Q5SWX3
    Related
    ENSP00000361851.1, ENST00000372765.5
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:384 → 511
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  10. XM_047425801.1 → XP_047281757.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X8

  11. XM_005270198.2 → XP_005270255.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X4

    See identical proteins and their annotated locations for XP_005270255.1

    UniProtKB/TrEMBL
    A0A8V8TQ60
    Related
    ENSP00000514974.1, ENST00000700396.1
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:431 → 558
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  12. XM_006717998.2 → XP_006718061.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X6

    See identical proteins and their annotated locations for XP_006718061.1

    UniProtKB/TrEMBL
    A8K6N9
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:404 → 531
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  13. XM_047425798.1 → XP_047281754.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X3

  14. XM_047425805.1 → XP_047281761.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X15

    Related
    ENSP00000393784.1, ENST00000433289.5

  15. XM_047425804.1 → XP_047281760.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X14

RNA

  1. XR_007061995.1 RNA Sequence

  2. XR_007061998.1 RNA Sequence

  3. XR_007062000.1 RNA Sequence

  4. XR_007061999.1 RNA Sequence

  5. XR_007061991.1 RNA Sequence

  6. XR_007061996.1 RNA Sequence

  7. XR_007061990.1 RNA Sequence

  8. XR_007061994.1 RNA Sequence

  9. XR_001747218.2 RNA Sequence

  10. XR_945822.2 RNA Sequence

  11. XR_945821.2 RNA Sequence

  12. XR_007061993.1 RNA Sequence

  13. XR_007061997.1 RNA Sequence

  14. XR_007061992.1 RNA Sequence

    Related
    ENST00000700399.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    74683897..74745947 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366856.1 → XP_054222831.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X13

  2. XM_054366855.1 → XP_054222830.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X12

  3. XM_054366848.1 → XP_054222823.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X5

  4. XM_054366850.1 → XP_054222825.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X7

  5. XM_054366852.1 → XP_054222827.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X9

  6. XM_054366844.1 → XP_054222819.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1

  7. XM_054366854.1 → XP_054222829.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X11

  8. XM_054366845.1 → XP_054222820.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X2

  9. XM_054366853.1 → XP_054222828.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X10

    UniProtKB/TrEMBL
    Q5SWX3

  10. XM_054366851.1 → XP_054222826.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X8

  11. XM_054366847.1 → XP_054222822.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X4

  12. XM_054366849.1 → XP_054222824.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X6

  13. XM_054366846.1 → XP_054222821.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X3

  14. XM_054366858.1 → XP_054222833.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X15

  15. XM_054366857.1 → XP_054222832.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X14

RNA

  1. XR_008488282.1 RNA Sequence

  2. XR_008488285.1 RNA Sequence

  3. XR_008488287.1 RNA Sequence

  4. XR_008488286.1 RNA Sequence

  5. XR_008488278.1 RNA Sequence

  6. XR_008488283.1 RNA Sequence

  7. XR_008488276.1 RNA Sequence

  8. XR_008488281.1 RNA Sequence

  9. XR_008488275.1 RNA Sequence

  10. XR_008488277.1 RNA Sequence

  11. XR_008488274.1 RNA Sequence

  12. XR_008488280.1 RNA Sequence

  13. XR_008488284.1 RNA Sequence

  14. XR_008488279.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_172172.1: Suppressed sequence

    Description
    NM_172172.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13555.4 GenPept UniProtKB/Swiss-Prot:Q13555

Gene LinkOut

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