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Serpina7 serpin family A member 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81806, updated on 2-Nov-2024

Summary

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Official Symbol
Serpina7provided by RGD
Official Full Name
serpin family A member 7provided by RGD
Primary source
RGD:619833
See related
EnsemblRapid:ENSRNOG00000011081 AllianceGenome:RGD:619833
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tbg
Summary
Enables hormone binding activity. Involved in several processes, including response to corticosterone; response to prostaglandin E; and response to vitamin A. Located in extracellular space. Biomarker of hyperthyroidism and hypothyroidism. Orthologous to human SERPINA7 (serpin family A member 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 213.8) See more
Orthologs
human mouse all
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Genomic context

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See Serpina7 in Genome Data Viewer
Location:
Xq32
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (107452044..107510958, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (102663242..102722319, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (110226565..110232202, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily E member 1, pseudogene 1 Neighboring gene UBX domain protein 2A, pseudogene 1 Neighboring gene glutamic acid-rich protein-like Neighboring gene uncharacterized LOC108349242 Neighboring gene PWWP domain containing 3B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Effects of vitamin A deficiency on thyroid function and serum thyroxine levels in the rat. Oba K, et al. J Nutr Sci Vitaminol (Tokyo), 1980. PMID 6785400
  2. Goiter formation following prostaglandin administration in rats. Lupulescu A. Am J Pathol, 1976 Oct. PMID 970439, Free PMC Article
  3. Re-expression of thyroxine-binding globulin in post-weaning rats during protein or energy malnutrition. Rouaze-Romet M, et al. Acta Endocrinol (Copenh), 1992 Nov. PMID 1471456
  4. Structural and functional microheterogeneity of rat thyroxine-binding globulin during ontogenesis. Rouaze-Romet M, et al. Biochem J, 1992 Aug 15. PMID 1520259, Free PMC Article
  5. Euthyroid sick syndrome in type I diabetes mellitus in children and adolescents. Tahirović H, et al. Acta Paediatr Hung, 1991. PMID 1867879

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables hormone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables thyroid hormone transmembrane transporter activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in post-embryonic development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to corticosterone IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to peptide hormone IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to prostaglandin E IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to steroid hormone IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to vitamin A IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in thyroid hormone transport IEA
Inferred from Electronic Annotation
more info
  
involved_in thyroid hormone transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
thyroxine-binding globulin
Names
T4-binding globulin
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antipeptidase, antitrypsin), member 7
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
serine (or cysteine) proteinase inhibitor clade A (alpha-1 antiproteinase antitrypsin) member 7
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
serpin A7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031128.1 → NP_112390.1  thyroxine-binding globulin precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/Swiss-Prot
    P35577
    UniProtKB/TrEMBL
    A0A140TAB0, A6KNW8
    Related
    ENSRNOP00000014739.5, ENSRNOT00000014739.8
    Conserved Domains (1) summary
    cd19555
    Location:48 → 425
    serpinA7_TBG; serpin family A member 7, thyroxine-binding globulin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    107452044..107510958 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039100095.2 → XP_038956023.1  thyroxine-binding globulin isoform X7

    Conserved Domains (1) summary
    cl38926
    Location:1 → 217
    serpin; SERine Proteinase INhibitors (serpin) family

  2. XM_039100093.2 → XP_038956021.1  thyroxine-binding globulin isoform X6

    Conserved Domains (1) summary
    cl38926
    Location:48 → 218
    serpin; SERine Proteinase INhibitors (serpin) family

  3. XM_039100092.2 → XP_038956020.1  thyroxine-binding globulin isoform X3

    UniProtKB/TrEMBL
    A0A1W2Q6F2
    Related
    ENSRNOP00000076228.2, ENSRNOT00000093401.3
    Conserved Domains (1) summary
    cl38926
    Location:4 → 248
    serpin; SERine Proteinase INhibitors (serpin) family

  4. XM_039100091.2 → XP_038956019.1  thyroxine-binding globulin isoform X2

    UniProtKB/TrEMBL
    A0A1W2Q6F2
    Conserved Domains (1) summary
    cl38926
    Location:4 → 258
    serpin; SERine Proteinase INhibitors (serpin) family

  5. XM_063280328.1 → XP_063136398.1  thyroxine-binding globulin isoform X1

  6. XM_063280329.1 → XP_063136399.1  thyroxine-binding globulin isoform X4

  7. XM_063280330.1 → XP_063136400.1  thyroxine-binding globulin isoform X5

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35577.2 GenPept UniProtKB/Swiss-Prot:P35577

Gene LinkOut

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