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ACA4 autoinhibited Ca(2+)-ATPase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 818754, updated on 18-Sep-2024

Summary

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Official Symbol
ACA4
Official Full Name
autoinhibited Ca(2+)-ATPase
Primary source
TAIR:AT2G41560
Locus tag
AT2G41560
See related
Araport:AT2G41560
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
''autoinhibited Ca(2+)-ATPase; autoinhibited Ca(2+)-ATPase; isoform 4; isoform 4''; T32G6.8; T32G6_8
Summary
Encodes a calmodulin-regulated Ca(2+)-ATPase that improves salt tolerance in yeast. Localized to the vacuole. Lesion mimic phenotype when mutation in the gene is combined with a mutation in ACA11. Lesion mimic phenotype of double knockout can be suppressed by nutritional supplements that increase anion levels (e.g. 15 mM Nitrate, Chloride, or Phosphate).
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Genomic context

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See ACA4 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
7
Sequence:
Chromosome: 2; NC_003071.7 (17332050..17337492, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene S-formylglutathione hydrolase Neighboring gene 6-phosphogluconate dehydrogenase family protein Neighboring gene Rho termination factor Neighboring gene pseudo Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Disruption of the vacuolar calcium-ATPases in Arabidopsis results in the activation of a salicylic acid-dependent programmed cell death pathway. Boursiac Y, et al. Plant Physiol, 2010 Nov. PMID 20837703, Free PMC Article
  2. Resting cytosol Ca2+ level maintained by Ca2+ pumps affects environmental responses in Arabidopsis. Li Z, et al. Plant Physiol, 2023 Apr 3. PMID 36715402, Free PMC Article
  3. The ACA4 gene of Arabidopsis encodes a vacuolar membrane calcium pump that improves salt tolerance in yeast. Geisler M, et al. Plant Physiol, 2000 Dec. PMID 11115896, Free PMC Article
  4. Genomic comparison of P-type ATPase ion pumps in Arabidopsis and rice. Baxter I, et al. Plant Physiol, 2003 Jun. PMID 12805592, Free PMC Article
  5. Genes encoding calmodulin-binding proteins in the Arabidopsis genome. Reddy VS, et al. J Biol Chem, 2002 Mar 22. PMID 11782485

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A double disruption of Arabidopsis vacuolar pumps ACA4 and ACA11 results in a high frequency of apoptosis-like lesions.
    Title: Disruption of the vacuolar calcium-ATPases in Arabidopsis results in the activation of a salicylic acid-dependent programmed cell death pathway.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001336925.1
NM_001336926.1
NM_001336927.1
NM_129719.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables P-type calcium transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables P-type calcium transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables calmodulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within defense response to bacterium IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within monoatomic anion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of programmed cell death IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to nematode HEP PubMed 
acts_upstream_of_or_within response to osmotic stress IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to salt stress IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in cytosol HDA PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in plant-type vacuole HDA PubMed 
located_in plant-type vacuole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plant-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vacuolar membrane HDA PubMed 
located_in vacuole HDA PubMed 
located_in vacuole TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
autoinhibited Ca(2+)-ATPase
NP_181687.1
  • ''autoinhibited Ca(2+)-ATPase, isoform 4'' (ACA4); FUNCTIONS IN: calcium-transporting ATPase activity, calmodulin binding; INVOLVED IN: in 6 processes; LOCATED IN: in 6 components; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, P-type, ATPase-associated domain (InterPro:IPR008250), ATPase, P-type, calcium-transporting, PMCA-type (InterPro:IPR006408), ATPase, P-type, H+ transporting proton pump (InterPro:IPR000695), ATPase, P-type cation-transporter, N-terminal (InterPro:IPR004014), Haloacid dehalogenase-like hydrolase (InterPro:IPR005834), ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (InterPro:IPR001757), ATPase, P-type phosphorylation site (InterPro:IPR018303), ATPase, P-type cation-transporter, C-terminal (InterPro:IPR006068); BEST Arabidopsis thaliana protein match is: autoinhibited Ca2+-ATPase 11 (TAIR:AT3G57330.1); Has 45699 Blast hits to 34603 proteins in 3211 species: Archae - 845; Bacteria - 31242; Metazoa - 4073; Fungi - 2705; Plants - 2048; Viruses - 3; Other Eukaryotes - 4783 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    17332050..17337492 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_129719.4 → NP_181687.1  autoinhibited Ca(2+)-ATPase, isoform 4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_181687.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O22218
    UniProtKB/TrEMBL
    A0A5S9X635
    Conserved Domains (2) summary
    TIGR01517
    Location:57 → 1009
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12515
    Location:4 → 48
    CaATP_NAI; Ca2+-ATPase N terminal autoinhibitory domain

  2. NM_001336925.1 → NP_001323669.1  autoinhibited Ca(2+)-ATPase, isoform 4 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VS00, A0A1P8AXT8

  3. NM_001336926.1 → NP_001323668.1  autoinhibited Ca(2+)-ATPase, isoform 4 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VS00, A0A1P8AXT8

  4. NM_001336927.1 → NP_001323670.1  autoinhibited Ca(2+)-ATPase, isoform 4 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VS00, A0A1P8AXT8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O22218.1

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