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TPK2 thiamine pyrophosphokinase 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 819084, updated on 18-Sep-2024

Summary

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Official Symbol
TPK2
Official Full Name
thiamine pyrophosphokinase 2
Primary source
TAIR:AT2G44750
Locus tag
AT2G44750
See related
Araport:AT2G44750
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F16B22.24; thiamin pyrophosphokinase 2
Summary
Encodes a thiamine pyrophosphokinase capable of producing thiamine pyrophosphate from free thiamine.
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Genomic context

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See TPK2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
6
Sequence:
Chromosome: 2; NC_003071.7 (18451426..18452875)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene WRKY family transcription factor Neighboring gene dihydroorotate dehydrogenase (DUF3598) Neighboring gene ELMO/CED-12 family protein Neighboring gene miscRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Thiamin pyrophosphokinase is required for thiamin cofactor activation in Arabidopsis. Ajjawi I, et al. Plant Mol Biol, 2007 Sep. PMID 17611796
  2. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

NM_130040.3
NM_180093.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables thiamine binding IEA
Inferred from Electronic Annotation
more info
  
enables thiamine diphosphokinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in thiamine diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within thiamine metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
thiamine pyrophosphokinase 2
NP_566026.1
  • thiamin pyrophosphokinase 2 (TPK2); CONTAINS InterPro DOMAIN/s: Thiamin pyrophosphokinase, vitamin B1-binding domain (InterPro:IPR007373), Thiamin pyrophosphokinase, eukaryotic (InterPro:IPR016966), Thiamin pyrophosphokinase (InterPro:IPR006282), Thiamin pyrophosphokinase, catalytic domain (InterPro:IPR007371); BEST Arabidopsis thaliana protein match is: thiamin pyrophosphokinase1 (TAIR:AT1G02880.3); Has 1413 Blast hits to 1411 proteins in 581 species: Archae - 0; Bacteria - 767; Metazoa - 135; Fungi - 134; Plants - 93; Viruses - 0; Other Eukaryotes - 284 (source: NCBI BLink).
NP_850424.1
  • thiamin pyrophosphokinase 2 (TPK2); CONTAINS InterPro DOMAIN/s: Thiamin pyrophosphokinase, vitamin B1-binding domain (InterPro:IPR007373), Thiamin pyrophosphokinase, eukaryotic (InterPro:IPR016966), Thiamin pyrophosphokinase (InterPro:IPR006282), Thiamin pyrophosphokinase, catalytic domain (InterPro:IPR007371); BEST Arabidopsis thaliana protein match is: thiamin pyrophosphokinase1 (TAIR:AT1G02880.3); Has 1352 Blast hits to 1350 proteins in 558 species: Archae - 0; Bacteria - 721; Metazoa - 134; Fungi - 134; Plants - 93; Viruses - 0; Other Eukaryotes - 270 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    18451426..18452875
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_180093.2 → NP_850424.1  thiamine pyrophosphokinase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850424.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4IV16, O80514, Q94B25
    UniProtKB/TrEMBL
    A0A5S9X710, A0A654F761
    Conserved Domains (1) summary
    PLN02714
    Location:27 → 255
    PLN02714; thiamin pyrophosphokinase

  2. NM_130040.3 → NP_566026.1  thiamine pyrophosphokinase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_566026.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A654F761, A0A7G2EI51
    Conserved Domains (1) summary
    PLN02714
    Location:27 → 253
    PLN02714; thiamin pyrophosphokinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F4IV16.1

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