SAP5 A20/AN1-like zinc finger family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: SAP5
Official Full Name: A20/AN1-like zinc finger family protein
Primary source: TAIR:AT3G12630
Locus tag: AT3G12630
See related: Araport:AT3G12630
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: stress associated protein 5
Summary: Encodes a protein with E3 ligase activity that acts as a positive regulator of stress responses in Arabidopsis.
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Genomic context

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See SAP5 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 1

Sequence:: Chromosome: 3; NC_003074.8 (4012107..4013583)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

While constitutive expression of MBP-1 leads to increased sensitivity to abscisic acid and stunted vegetative growth, the growth defect can be reversed by co-expression of SAP5.
Title: AtMBP-1, an alternative translation product of LOS2, affects abscisic acid responses and is modulated by the E3 ubiquitin ligase AtSAP5.
AtSAP5 participates in polyubiquitin recognition in plants and that the dialipathic patch in AtSAP5 is critical in binding K48-linked polyubiquitn chains.
Title: Polyubiquitin recognition by AtSAP5, an A20-type zinc finger containing protein from Arabidopsis thaliana.
SAP5, one member of the Stress Associated Protein gene family, was identified by its expression in response to salinity, osmotic, drought and cold stress. SAP5 has E3 ligase activity and acts as a positive regulator of stress responses. [SAP5]
Title: Arabidopsis SAP5 functions as a positive regulator of stress responses and exhibits E3 ubiquitin ligase activity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_112098.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein autoubiquitination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to osmotic stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to osmotic stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to water deprivation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: A20/AN1-like zinc finger family protein

NP_566429.1

A20/AN1-like zinc finger family protein; FUNCTIONS IN: DNA binding, zinc ion binding; INVOLVED IN: biological_process unknown; LOCATED IN: cellular_component unknown; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, AN1-type (InterPro:IPR000058), Zinc finger, A20-type (InterPro:IPR002653); BEST Arabidopsis thaliana protein match is: A20/AN1-like zinc finger family protein (TAIR:AT2G36320.1); Has 1013 Blast hits to 1009 proteins in 143 species: Archae - 0; Bacteria - 0; Metazoa - 428; Fungi - 9; Plants - 446; Viruses - 6; Other Eukaryotes - 124 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

4012107..4013583

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_112098.2 → NP_566429.1 A20/AN1-like zinc finger family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_566429.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9LHJ8

UniProtKB/TrEMBL

A0A178VGK6, A0A5S9XBF1

Conserved Domains (1) summary

smart00154
Location:101 → 138

ZnF_AN1; AN1-like Zinc finger