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RHD3 Root hair defective 3 GTP-binding protein (RHD3) [ Arabidopsis thaliana (thale cress) ]

Gene ID: 820600, updated on 13-Mar-2024

Summary

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Gene symbol
RHD3
Gene description
Root hair defective 3 GTP-binding protein (RHD3)
Primary source
Araport:AT3G13870
Locus tag
AT3G13870
See related
TAIR:AT3G13870
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
GOLGI MUTANT 8; GOM8; ROOT HAIR DEFECTIVE 3
Summary
required for regulated cell expansion and normal root hair development. Encodes an evolutionarily conserved protein with putative GTP-binding motifs that is implicated in the control of vesicle trafficking between the endoplasmic reticulum and the Golgi compartments.
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Genomic context

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See RHD3 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
23
Sequence:
Chromosome: 3; NC_003074.8 (4565370..4571355, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene heat shock protein 60-3A Neighboring gene ncRNA Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene Ribosomal protein L34

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Efficient ER Fusion Requires a Dimerization and a C-Terminal Tail Mediated Membrane Anchoring of RHD3. Sun J, et al. Plant Physiol, 2018 Jan. PMID 29138354, Free PMC Article
  2. Phosphorylation of the C Terminus of RHD3 Has a Critical Role in Homotypic ER Membrane Fusion in Arabidopsis. Ueda H, et al. Plant Physiol, 2016 Feb. PMID 26684656, Free PMC Article
  3. Phospholipid biosynthesis increases in RHD3-defective mutants. Maneta-Peyret L, et al. Plant Signal Behav, 2014. PMID 25763700, Free PMC Article
  4. Arabidopsis ROOT HAIR DEFECTIVE3 is involved in nitrogen starvation-induced anthocyanin accumulation. Wang J, et al. J Integr Plant Biol, 2015 Aug. PMID 25494721
  5. ER stress signaling requires RHD3, a functionally conserved ER-shaping GTPase. Lai YS, et al. J Cell Sci, 2014 Aug 1. PMID 24876222, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Arabidopsis reticulons inhibit ROOT HAIR DEFECTIVE3 to form a stable tubular endoplasmic reticulum network.
    Title: Arabidopsis reticulons inhibit ROOT HAIR DEFECTIVE3 to form a stable tubular endoplasmic reticulum network.
  2. LUNAPARK Is an E3 Ligase That Mediates Degradation of ROOT HAIR DEFECTIVE3 to Maintain a Tubular ER Network in Arabidopsis.
    Title: LUNAPARK Is an E3 Ligase That Mediates Degradation of ROOT HAIR DEFECTIVE3 to Maintain a Tubular ER Network in Arabidopsis.
  3. Armadillo-repeat kinesin1 interacts with Arabidopsis atlastin RHD3 to move ER with plus-end of microtubules.
    Title: Armadillo-repeat kinesin1 interacts with Arabidopsis atlastin RHD3 to move ER with plus-end of microtubules.
  4. Turnip Mosaic Virus 6K2 protein physically interacts with RHD3 protein, and redirects RHD3 from the endoplasmic reticulum to viral replication vesicles.Turnip Mosaic Virus replication vesicles requires RHD3 for efficient viral replication and movement.
    Title: A Host ER Fusogen Is Recruited by Turnip Mosaic Virus for Maturation of Viral Replication Vesicles.
  5. This work contributes to a better understanding of a coordinated action of RHD3 in the fusion of endoplasmic reticulum membranes.
    Title: Efficient ER Fusion Requires a Dimerization and a C-Terminal Tail Mediated Membrane Anchoring of RHD3.
  6. RHD3 is required for the formation of a fine endoplasmic reticulum structure in the subapical zone of growing root hairs.
    Title: A GTPase-Dependent Fine ER Is Required for Localized Secretion in Polarized Growth of Root Hairs1.
  7. phosphorylation-stimulated oligomerization of RHD3 enhances endoplasmic reticulum (ER) membrane fusion to form the ER network.
    Title: Phosphorylation of the C Terminus of RHD3 Has a Critical Role in Homotypic ER Membrane Fusion in Arabidopsis.
  8. and function. RHD3 was initially identified as a gene involved in root hair development. This study uncovered a new physiological function of RHD3 in nitrogen starvation-induced anthocyanin accumulation and ethylene homeostasis.
    Title: Arabidopsis ROOT HAIR DEFECTIVE3 is involved in nitrogen starvation-induced anthocyanin accumulation.
  9. We analyzed the lipid fraction of rhd3 mutants at qualitative and quantitative levels. We observed an increase of the amount of phospholipids but also of proteins in the mutants, indicating an overall increase of ER membranes.
    Title: Phospholipid biosynthesis increases in RHD3-defective mutants.
  10. required for the unfolded protein response, an essential endoplasmic reticulum signaling pathway
    Title: ER stress signaling requires RHD3, a functionally conserved ER-shaping GTPase.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_112241.4
NM_202579.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables GTP binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell tip growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within endoplasmic reticulum to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within plant-type cell wall biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within root epidermal cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytosol HDA PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in plant-type vacuole HDA PubMed 
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
Root hair defective 3 GTP-binding protein (RHD3)
NP_188003.1
  • ROOT HAIR DEFECTIVE 3 (RHD3); FUNCTIONS IN: GTP binding; INVOLVED IN: root epidermal cell differentiation, plant-type cell wall biogenesis, ER to Golgi vesicle-mediated transport, actin cytoskeleton organization, cell tip growth; LOCATED IN: endoplasmic reticulum, plasma membrane, cytoplasm; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Root hair defective 3 GTP-binding (InterPro:IPR008803); BEST Arabidopsis thaliana protein match is: Root hair defective 3 GTP-binding protein (RHD3) (TAIR:AT1G72960.1); Has 563 Blast hits to 546 proteins in 189 species: Archae - 0; Bacteria - 2; Metazoa - 79; Fungi - 191; Plants - 135; Viruses - 0; Other Eukaryotes - 156 (source: NCBI BLink).
NP_974308.1
  • ROOT HAIR DEFECTIVE 3 (RHD3); FUNCTIONS IN: GTP binding; INVOLVED IN: root epidermal cell differentiation, plant-type cell wall biogenesis, ER to Golgi vesicle-mediated transport, actin cytoskeleton organization, cell tip growth; LOCATED IN: endoplasmic reticulum, plasma membrane, cytoplasm; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Root hair defective 3 GTP-binding (InterPro:IPR008803); BEST Arabidopsis thaliana protein match is: Root hair defective 3 GTP-binding protein (RHD3) (TAIR:AT1G72960.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    4565370..4571355 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_112241.4 → NP_188003.1  Root hair defective 3 GTP-binding protein (RHD3) [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_188003.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P93042, Q0WL83, Q3EB66
    UniProtKB/TrEMBL
    A0A178VD05, A0A5S9XBX4
    Conserved Domains (1) summary
    pfam05879
    Location:43 → 781
    RHD3; Root hair defective 3 GTP-binding protein (RHD3)

  2. NM_202579.1 → NP_974308.1  Root hair defective 3 GTP-binding protein (RHD3) [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_974308.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VD05, A0A5S9XBX4
    Conserved Domains (1) summary
    cl21455
    Location:4 → 717
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P93042.1

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