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DJ1A Class I glutamine amidotransferase-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 820728, updated on 18-Sep-2024

Summary

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Official Symbol
DJ1A
Official Full Name
Class I glutamine amidotransferase-like superfamily protein
Primary source
TAIR:AT3G14990
Locus tag
AT3G14990
See related
Araport:AT3G14990
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtDJ1A; DJ-1 homolog A; DJ-1a
Summary
Encodes a homolog of animal DJ-1 superfamily protein. In the A. thaliana genome, three genes encoding close homologs of human DJ-1 were identified AT3G14990 (DJ1A), AT1G53280 (DJ1B) and AT4G34020 (DJ1C). Among the three homologs, DJ1C is essential for chloroplast development and viability. It exhibits glyoxalase activity towards glyoxal and methylglyoxal.
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Genomic context

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See DJ1A in Genome Data Viewer
Location:
chromosome: 3
Exon count:
8
Sequence:
Chromosome: 3; NC_003074.8 (5047376..5049971)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene RING/U-box superfamily protein Neighboring gene Acyl-CoA N-acyltransferase with RING/FYVE/PHD-type zinc finger protein Neighboring gene uncharacterized protein Neighboring gene cobalt ion binding protein Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene Lactate/malate dehydrogenase family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ROS removal by DJ-1: Arabidopsis as a new model to understand Parkinson's Disease. Xu XM, et al. Plant Signal Behav, 2010 Aug. PMID 20671441, Free PMC Article
  2. Novel glyoxalases from Arabidopsis thaliana. Kwon K, et al. FEBS J, 2013 Jul. PMID 23651081
  3. The Arabidopsis DJ-1a protein confers stress protection through cytosolic SOD activation. Xu XM, et al. J Cell Sci, 2010 May 15. PMID 20406884
  4. The plasmodesmal protein PDLP1 localises to haustoria-associated membranes during downy mildew infection and regulates callose deposition. Caillaud MC, et al. PLoS Pathog, 2014 Oct. PMID 25393742, Free PMC Article
  5. The vegetative vacuole proteome of Arabidopsis thaliana reveals predicted and unexpected proteins. Carter C, et al. Plant Cell, 2004 Dec. PMID 15539469, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DJ-1 directly influences SOD activity in a highly conserved manner to remove ROS, thereby preventing cell death.
    Title: ROS removal by DJ-1: Arabidopsis as a new model to understand Parkinson's Disease.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001035621.1
NM_112361.5
NM_180257.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables glyoxalase III activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of cellular response to oxidative stress IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plant-type vacuole HDA PubMed 
located_in plasma membrane HDA PubMed 
located_in plasmodesma HDA PubMed 

General protein information

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Preferred Names
Class I glutamine amidotransferase-like superfamily protein
NP_001030698.1
  • Class I glutamine amidotransferase-like superfamily protein; FUNCTIONS IN: catalytic activity; INVOLVED IN: response to cadmium ion, thiamin biosynthetic process; LOCATED IN: plasma membrane, vacuole; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: DJ-1 (InterPro:IPR006287), ThiJ/PfpI (InterPro:IPR002818); BEST Arabidopsis thaliana protein match is: Class I glutamine amidotransferase-like superfamily protein (TAIR:AT1G53280.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_188117.1
  • Class I glutamine amidotransferase-like superfamily protein; FUNCTIONS IN: catalytic activity; INVOLVED IN: response to cadmium ion, thiamin biosynthetic process; LOCATED IN: plasma membrane, vacuole; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: DJ-1 (InterPro:IPR006287), ThiJ/PfpI (InterPro:IPR002818); BEST Arabidopsis thaliana protein match is: Class I glutamine amidotransferase-like superfamily protein (TAIR:AT1G53280.1); Has 10802 Blast hits to 6415 proteins in 1883 species: Archae - 336; Bacteria - 9086; Metazoa - 526; Fungi - 85; Plants - 335; Viruses - 0; Other Eukaryotes - 434 (source: NCBI BLink).
NP_850588.1
  • Class I glutamine amidotransferase-like superfamily protein; FUNCTIONS IN: catalytic activity; INVOLVED IN: response to cadmium ion, thiamin biosynthetic process; LOCATED IN: plasma membrane, vacuole; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: DJ-1 (InterPro:IPR006287), ThiJ/PfpI (InterPro:IPR002818); BEST Arabidopsis thaliana protein match is: Class I glutamine amidotransferase-like superfamily protein (TAIR:AT1G53280.1); Has 10809 Blast hits to 6441 proteins in 1899 species: Archae - 334; Bacteria - 9077; Metazoa - 525; Fungi - 83; Plants - 359; Viruses - 0; Other Eukaryotes - 431 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    5047376..5049971
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_112361.5 → NP_188117.1  Class I glutamine amidotransferase-like superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_188117.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FPF0, Q9LKA6
    UniProtKB/TrEMBL
    A0A178VPH3, A0A5S9XDN4
    Conserved Domains (2) summary
    cd03135
    Location:231 → 377
    GATase1_DJ-1; Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1
    TIGR01383
    Location:7 → 185
    not_thiJ; DJ-1 family protein

  2. NM_001035621.1 → NP_001030698.1  Class I glutamine amidotransferase-like superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001030698.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FPF0
    Conserved Domains (1) summary
    cd03135
    Location:208 → 354
    GATase1_DJ-1; Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1

  3. NM_180257.1 → NP_850588.1  Class I glutamine amidotransferase-like superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850588.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FPF0
    Conserved Domains (1) summary
    cd03135
    Location:208 → 354
    GATase1_DJ-1; Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FPF0.1

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