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EBP ethylene-responsive element binding protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 820929, updated on 18-Sep-2024

Summary

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Official Symbol
EBP
Official Full Name
ethylene-responsive element binding protein
Primary source
TAIR:AT3G16770
Locus tag
AT3G16770
See related
Araport:AT3G16770
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATEBP; ERF72; ETHYLENE RESPONSE FACTOR 72; ethylene-responsive element binding protein; MGL6.1; RAP2.3; RELATED TO AP2 3
Summary
Encodes a member of the ERF (ethylene response factor) subfamily B-2 of the plant specific ERF/AP2 transcription factor family (RAP2.3). The protein contains one AP2 domain. There are 5 members in this subfamily including RAP2.2 AND RAP2.12.It is localized to the nucleus and acts as a transcriptional activator through the GCC-box. It has been identified as a suppressor of Bax-induced cell death by functional screening in yeast and can also suppress Bax-induced cell death in tobacco plants. Overexpression of this gene in tobacco BY-2 cells confers resistance to H2O2 and heat stresses. Overexpression in Arabidopsis causes upregulation of PDF1.2 and GST6. It is part of the ethylene signaling pathway and is predicted to act downstream of EIN2 and CTR1, but not under EIN3.
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Genomic context

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See EBP in Genome Data Viewer
Location:
chromosome: 3
Exon count:
2
Sequence:
Chromosome: 3; NC_003074.8 (5705541..5707084)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene Ribosomal protein L19e family protein Neighboring gene phospholipase D P1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RAP2.3 negatively regulates nitric oxide biosynthesis and related responses through a rheostat-like mechanism in Arabidopsis. León J, et al. J Exp Bot, 2020 May 30. PMID 32052059, Free PMC Article
  2. A glucocorticoid-inducible transcription system causes severe growth defects in Arabidopsis and induces defense-related genes. Kang HG, et al. Plant J, 1999 Oct. PMID 10571872
  3. Arabidopsis thaliana ethylene-responsive element binding protein (AtEBP), an ethylene-inducible, GCC box DNA-binding protein interacts with an ocs element binding protein. Büttner M, et al. Proc Natl Acad Sci U S A, 1997 May 27. PMID 9159183, Free PMC Article
  4. Arabidopsis Acyl-CoA-binding protein ACBP2 interacts with an ethylene-responsive element-binding protein, AtEBP, via its ankyrin repeats. Li HY, et al. Plant Mol Biol, 2004 Jan. PMID 15159625
  5. Functional analysis of Arabidopsis ethylene-responsive element binding protein conferring resistance to Bax and abiotic stress-induced plant cell death. Ogawa T, et al. Plant Physiol, 2005 Jul. PMID 15980186, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RAP2.3 negatively regulates nitric oxide biosynthesis and related responses through a rheostat-like mechanism in Arabidopsis.
    Title: RAP2.3 negatively regulates nitric oxide biosynthesis and related responses through a rheostat-like mechanism in Arabidopsis.
  2. found that hypocotyl cell elongation is regulated by a network involving ethylene, auxin, and BR signalling, which is mediated by interactions among ERF72, ARF6, and BZR1. ERF72 interacted directly with ARF6 and BZR1 in vitro and in vivo, and it antagonised regulation by ARF6 and BZR1 of the transcription of BEE3 and XTH7
    Title: ERF72 interacts with ARF6 and BZR1 to regulate hypocotyl elongation in Arabidopsis.
  3. RAP2.2, RAP2.3 and RAP2.12 play a role in modulating oxidative and osmotic stress tolerance during submergence acclimation.
    Title: The low oxygen, oxidative and osmotic stress responses synergistically act through the ethylene response factor VII genes RAP2.12, RAP2.2 and RAP2.3.
  4. AtEB domains bind to a target DNA motif with a universal CG step core recognition and different flanking bases preference
    Title: Four divergent Arabidopsis ethylene-responsive element-binding factor domains bind to a target DNA motif with a universal CG step core recognition and different flanking bases preference.
  5. Interaction of acyl-CoA-binding protein 4 with the ethylene-responsive element binding protein is induced by ethylene.
    Title: Ethylene- and pathogen-inducible Arabidopsis acyl-CoA-binding protein 4 interacts with an ethylene-responsive element binding protein.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_112550.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within ethylene-activated signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within heat acclimation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within response to cytokinin IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to ethylene IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to ethylene IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to jasmonic acid IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to nitrate starvation IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to other organism IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ethylene-responsive element binding protein
NP_188299.1
  • ethylene-responsive element binding protein (EBP); CONTAINS InterPro DOMAIN/s: DNA-binding, integrase-type (InterPro:IPR016177), Pathogenesis-related transcriptional factor/ERF, DNA-binding (InterPro:IPR001471); BEST Arabidopsis thaliana protein match is: Integrase-type DNA-binding superfamily protein (TAIR:AT2G47520.1); Has 5957 Blast hits to 5752 proteins in 250 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 5929; Viruses - 4; Other Eukaryotes - 24 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    5705541..5707084
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_112550.5 → NP_188299.1  ethylene-responsive element binding protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_188299.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O04382, O23105, P42736
    UniProtKB/TrEMBL
    A0A5S9XEB1, A0A654F7W0, A0A7G2ENB6
    Conserved Domains (1) summary
    smart00380
    Location:79 → 135
    AP2; DNA-binding domain in plant proteins such as APETALA2 and EREBPs
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P42736.2

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