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NPC4 non-specific phospholipase C4 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 821243, updated on 18-Sep-2024

Summary

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Official Symbol
NPC4
Official Full Name
non-specific phospholipase C4
Primary source
TAIR:AT3G03530
Locus tag
AT3G03530
See related
Araport:AT3G03530
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
non-specific phospholipase C4; T21P5.5; T21P5_5
Summary
PHOSPHOESTERASE FAMILY PROTEIN, NPC4 is significantly induced upon phosphate starvation and plays an important role in the supply of inorganic phosphate and diacylglycerol from membrane-phospholipids during phosphate deprivation.
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Genomic context

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See NPC4 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
5
Sequence:
Chromosome: 3; NC_003074.8 (842499..845096, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Phototropic-responsive NPH3 family protein Neighboring gene non-specific phospholipase C3 Neighboring gene non-specific phospholipase C5 Neighboring gene RING/U-box superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Insights into the mechanism of phospholipid hydrolysis by plant non-specific phospholipase C. Fan R, et al. Nat Commun, 2023 Jan 12. PMID 36635324, Free PMC Article
  2. The phosphatidylcholine-hydrolysing phospholipase C NPC4 plays a role in response of Arabidopsis roots to salt stress. Kocourková D, et al. J Exp Bot, 2011 Jul. PMID 21525137, Free PMC Article
  3. Nonspecific phospholipase C NPC4 promotes responses to abscisic acid and tolerance to hyperosmotic stress in Arabidopsis. Peters C, et al. Plant Cell, 2010 Aug. PMID 20699393, Free PMC Article
  4. A novel phosphatidylcholine-hydrolyzing phospholipase C induced by phosphate starvation in Arabidopsis. Nakamura Y, et al. J Biol Chem, 2005 Mar 4. PMID 15618226
  5. Nonspecific phospholipases C3 and C4 interact with PIN-FORMED2 to regulate growth and tropic responses in Arabidopsis. Li T, et al. Plant Cell, 2024 May 29. PMID 38442314,

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nonspecific phospholipases C3 and C4 interact with PIN-FORMED2 to regulate growth and tropic responses in Arabidopsis.
    Title: Nonspecific phospholipases C3 and C4 interact with PIN-FORMED2 to regulate growth and tropic responses in Arabidopsis.
  2. Insights into the mechanism of phospholipid hydrolysis by plant non-specific phospholipase C.
    Title: Insights into the mechanism of phospholipid hydrolysis by plant non-specific phospholipase C.
  3. Under salt stress npc4 plants had shorter roots, lower fresh weight, and reduced seed germination. Expression levels of abscisic acid-related genes ABI1, ABI2, RAB18, PP2CA, and SOT12 were substantially reduced in salt-treated npc4 plants.
    Title: The phosphatidylcholine-hydrolysing phospholipase C NPC4 plays a role in response of Arabidopsis roots to salt stress.
  4. NPC4 plays an important role in plant response to abscisic acid, drought, and high salinity.
    Title: Nonspecific phospholipase C NPC4 promotes responses to abscisic acid and tolerance to hyperosmotic stress in Arabidopsis.
  5. NPC4 plays an important role in the supply of both inorganic phosphate and diacylglycerol from membrane-localized phospholipids [NPC4]
    Title: A novel phosphatidylcholine-hydrolyzing phospholipase C induced by phosphate starvation in Arabidopsis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_111224.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables inositol phosphorylceramide phospholipase activity IDA
Inferred from Direct Assay
more info
  
enables phosphatidylcholine phospholipase C activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase C activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within phospholipid catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
non-specific phospholipase C4
NP_566206.1
  • non-specific phospholipase C4 (NPC4); FUNCTIONS IN: hydrolase activity, acting on ester bonds, phospholipase C activity; INVOLVED IN: phospholipid catabolic process; LOCATED IN: plasma membrane; CONTAINS InterPro DOMAIN/s: Phosphoesterase (InterPro:IPR007312); BEST Arabidopsis thaliana protein match is: non-specific phospholipase C5 (TAIR:AT3G03540.1); Has 2107 Blast hits to 2050 proteins in 380 species: Archae - 32; Bacteria - 1750; Metazoa - 0; Fungi - 127; Plants - 153; Viruses - 0; Other Eukaryotes - 45 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    842499..845096 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_111224.3 → NP_566206.1  non-specific phospholipase C4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_566206.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9SRQ7
    UniProtKB/TrEMBL
    A0A178VGE2, A0A5S9X8T4, A0A654F3Q9
    Conserved Domains (1) summary
    pfam04185
    Location:14 → 381
    Phosphoesterase; Phosphoesterase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SRQ7.1

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