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TSK tetratricopeptide repeat (TPR)-containing protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 821404, updated on 18-Sep-2024

Summary

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Official Symbol
TSK
Official Full Name
tetratricopeptide repeat (TPR)-containing protein
Primary source
TAIR:AT3G18730
Locus tag
AT3G18730
See related
Araport:AT3G18730
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
BRU1; BRUSHY1; MGO3; MGOUN3; TONSOKU
Summary
Encodes a protein with an important role in cell division control and plant morphogenesis and may also play a role in genome maintenance. May be involved in mitosis through interaction with TSA1. In cells synchronized for cell division, TSA1 and TSK relocalize to ends of spindle microtubules that are ahead of separating chromatids during metaphase and anaphase of mitosis.
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Genomic context

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See TSK in Genome Data Viewer
Location:
chromosome: 3
Exon count:
18
Sequence:
Chromosome: 3; NC_003074.8 (6445852..6453201, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene F-box family protein Neighboring gene Ribosomal protein L7Ae/L30e/S12e/Gadd45 family protein Neighboring gene with no lysine (K) kinase 6 Neighboring gene Translation elongation factor EF1B/ribosomal protein S6 family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TONSOKU is required for the maintenance of repressive chromatin modifications in Arabidopsis. Wang L, et al. Cell Rep, 2023 Jul 25. PMID 37393621
  2. BRUSHY1/TONSOKU/MGOUN3 is required for heat stress memory. Brzezinka K, et al. Plant Cell Environ, 2019 Mar. PMID 29884991
  3. Ectopic gene expression and organogenesis in Arabidopsis mutants missing BRU1 required for genome maintenance. Ohno Y, et al. Genetics, 2011 Sep. PMID 21705754, Free PMC Article
  4. A novel Arabidopsis gene TONSOKU is required for proper cell arrangement in root and shoot apical meristems. Suzuki T, et al. Plant J, 2004 May. PMID 15125773
  5. MGOUN3, an Arabidopsis gene with TetratricoPeptide-Repeat-related motifs, regulates meristem cellular organization. Guyomarc'h S, et al. J Exp Bot, 2004 Mar. PMID 14966212

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TONSOKU is required for the maintenance of repressive chromatin modifications in Arabidopsis.
    Title: TONSOKU is required for the maintenance of repressive chromatin modifications in Arabidopsis.
  2. The histone H3.1 variant regulates TONSOKU-mediated DNA repair during replication.
    Title: The histone H3.1 variant regulates TONSOKU-mediated DNA repair during replication.
  3. required for heat stress memory
    Title: BRUSHY1/TONSOKU/MGOUN3 is required for heat stress memory.
  4. the contribution of both MGO3 and GIP1 to the regulation of centromeric cohesion in Arabidopsis
    Title: MGO3 and GIP1 act synergistically for the maintenance of centromeric cohesion.
  5. BRU1 has a function related to the stability of subchromosomal gene regulation in the euchromatic regions.
    Title: Ectopic gene expression and organogenesis in Arabidopsis mutants missing BRU1 required for genome maintenance.
  6. MGO3 is required for the correct transition to flowering and this may be mediated by histone acetylation and associated changes in FLC expression.
    Title: MGOUN3: evidence for chromatin-mediated regulation of FLC expression.
  7. TONSOKU(TSK)/MGOUN3/BRUSHY1 of Arabidopsis thaliana encodes a nuclear leucine-glycine-aspargine (LGN) domain protein involved in genome maintenance; TSK is required during the cell cycle. [TSK]
    Title: TONSOKU is expressed in S phase of the cell cycle and its defect delays cell cycle progression in Arabidopsis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_112759.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epigenetic regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within meristem structural organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of meristem structural organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tetratricopeptide repeat (TPR)-containing protein
NP_188503.2
  • TONSOKU (TSK); FUNCTIONS IN: protein binding; INVOLVED IN: G2/M transition of mitotic cell cycle, meristem structural organization, regulation of meristem structural organization, cell division; LOCATED IN: nucleus, membrane; EXPRESSED IN: leaf; CONTAINS InterPro DOMAIN/s: Tetratricopeptide-like helical (InterPro:IPR011990), Tetratricopeptide repeat (InterPro:IPR019734); Has 6425 Blast hits to 3886 proteins in 382 species: Archae - 66; Bacteria - 1534; Metazoa - 3543; Fungi - 23; Plants - 266; Viruses - 0; Other Eukaryotes - 993 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    6445852..6453201 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_112759.5 → NP_188503.2  tetratricopeptide repeat (TPR)-containing protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_188503.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q6IE93, Q6Q4D0, Q769D5, Q7XAG5, Q9LSA4
    UniProtKB/TrEMBL
    A0A654F8I2
    Conserved Domains (4) summary
    cd00116
    Location:924 → 1160
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:900 → 925
    LRR_RI; leucine-rich repeat [structural motif]
    sd00006
    Location:164 → 192
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:22 → 98
    TPR_12; Tetratricopeptide repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6Q4D0.2

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