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MNS2 alpha-mannosidase 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 821668, updated on 18-Sep-2024

Summary

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Official Symbol
MNS2
Official Full Name
alpha-mannosidase 2
Primary source
TAIR:AT3G21160
Locus tag
AT3G21160
See related
Araport:AT3G21160
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
alpha-mannosidase 2; ALPHA-MANNOSIDASE IA; MANIA; MSA6.31
Summary
Encodes an alpha-mannosidase I enzyme responsible for N-glycan maturation.
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Genomic context

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See MNS2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
14
Sequence:
Chromosome: 3; NC_003074.8 (7413776..7418484, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene F-box and associated interaction domains-containing protein Neighboring gene Pyridoxamine 5'-phosphate oxidase family protein Neighboring gene B-box 32 Neighboring gene F-box/associated interaction domain protein Neighboring gene F-box/associated interaction domain protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two Arabidopsis thaliana Golgi alpha-mannosidase I enzymes are responsible for plant N-glycan maturation. Kajiura H, et al. Glycobiology, 2010 Feb. PMID 19914916
  2. Trimming of N-Glycans by the Golgi-Localized α-1,2-Mannosidases, MNS1 and MNS2, Is Crucial for Maintaining RSW2 Protein Abundance during Salt Stress in Arabidopsis. Liu C, et al. Mol Plant, 2018 May 7. PMID 29409894
  3. Class I alpha-mannosidases are required for N-glycan processing and root development in Arabidopsis thaliana. Liebminger E, et al. Plant Cell, 2009 Dec. PMID 20023195, Free PMC Article
  4. Identification of proteins that interact with catalytically active calcium-dependent protein kinases from Arabidopsis. Uno Y, et al. Mol Genet Genomics, 2009 Apr. PMID 19130088
  5. Separating Golgi Proteins from Cis to Trans Reveals Underlying Properties of Cisternal Localization. Parsons HT, et al. Plant Cell, 2019 Sep. PMID 31266899, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MNS1/2-mediated mannose trimming of N-glycans is crucial in modulating glycoprotein abundance to withstand salt stress in plants
    Title: Trimming of N-Glycans by the Golgi-Localized α-1,2-Mannosidases, MNS1 and MNS2, Is Crucial for Maintaining RSW2 Protein Abundance during Salt Stress in Arabidopsis.
  2. data indicate that either AtMANIa or AtMANIb can function as the Golgi alpha-mannosidase I that produces the Man(5)GlcNAc(2) N-glycan structure necessary for complex N-glycan synthesis. [MANIa]
    Title: Two Arabidopsis thaliana Golgi alpha-mannosidase I enzymes are responsible for plant N-glycan maturation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001338506.1
NM_113010.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables alpha-mannosidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within N-glycan processing IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within N-glycan processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within root development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus HDA PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus ISM
Inferred from Sequence Model
more info
  
located_in Golgi cis cisterna HDA PubMed 
located_in endosome HDA PubMed 
located_in trans-Golgi network HDA PubMed 

General protein information

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Preferred Names
alpha-mannosidase 2
NP_566675.1
  • alpha-mannosidase 2 (MNS2); CONTAINS InterPro DOMAIN/s: Glycoside hydrolase, family 47 (InterPro:IPR001382); BEST Arabidopsis thaliana protein match is: alpha-mannosidase 1 (TAIR:AT1G51590.1); Has 2046 Blast hits to 1918 proteins in 195 species: Archae - 0; Bacteria - 11; Metazoa - 790; Fungi - 842; Plants - 175; Viruses - 0; Other Eukaryotes - 228 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    7413776..7418484 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_113010.3 → NP_566675.1  alpha-mannosidase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_566675.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8H116, Q94A04, Q9LJB6
    UniProtKB/TrEMBL
    A0A178VCU4
    Conserved Domains (1) summary
    pfam01532
    Location:105 → 537
    Glyco_hydro_47; Glycosyl hydrolase family 47

  2. NM_001338506.1 → NP_001327148.1  alpha-mannosidase 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1I9LRE8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8H116.1

Gene LinkOut

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