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RNR2A ribonucleotide reductase 2A [ Arabidopsis thaliana (thale cress) ]

Gene ID: 821937, updated on 18-Sep-2024

Summary

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Official Symbol
RNR2A
Official Full Name
ribonucleotide reductase 2A
Primary source
TAIR:AT3G23580
Locus tag
AT3G23580
See related
Araport:AT3G23580
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ribonucleotide reductase 2A; RNR2
Summary
Encodes one of the 3 ribonucleotide reductase (RNR) small subunit genes (RNR2A). Functionally redundant with the ribonucleotide reductase TSO2. mRNA was shown to specifically accumulate during the S-phase of the cell cycle in synchronized tobacco BY2 cells. Critical for cell cycle progression, DNA damage repair and plant development.
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Genomic context

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See RNR2A in Genome Data Viewer
Location:
chromosome: 3
Exon count:
9
Sequence:
Chromosome: 3; NC_003074.8 (8459838..8462815)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene MATE efflux family protein Neighboring gene MATE efflux family protein Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An active ribonucleotide reductase from Arabidopsis thaliana cloning, expression and characterization of the large subunit. Sauge-Merle S, et al. Eur J Biochem, 1999 Nov. PMID 10542051
  2. Molecular characterization and cell cycle-regulated expression of a cDNA clone from Arabidopsis thaliana homologous to the small subunit of ribonucleotide reductase. Philipps G, et al. FEBS Lett, 1995 Jan 16. PMID 7821432
  3. Arabidopsis ribonucleotide reductases are critical for cell cycle progression, DNA damage repair, and plant development. Wang C, et al. Plant Cell, 2006 Feb. PMID 16399800, Free PMC Article
  4. Ribonucleotide reductase regulation in response to genotoxic stress in Arabidopsis. Roa H, et al. Plant Physiol, 2009 Sep. PMID 19571309, Free PMC Article
  5. COP9 signalosome subunit 7 from Arabidopsis interacts with and regulates the small subunit of ribonucleotide reductase (RNR2). Halimi Y, et al. Plant Mol Biol, 2011 Sep. PMID 21614643

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

NM_113261.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ribonucleotide metabolic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
part_of ribonucleoside-diphosphate reductase complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
ribonucleotide reductase 2A
NP_189000.1
  • ribonucleotide reductase 2A (RNR2A); CONTAINS InterPro DOMAIN/s: Ribonucleotide reductase-related (InterPro:IPR012348), Ribonucleotide reductase (InterPro:IPR000358), Ferritin/ribonucleotide reductase-like (InterPro:IPR009078); BEST Arabidopsis thaliana protein match is: Ferritin/ribonucleotide reductase-like family protein (TAIR:AT3G27060.1); Has 9602 Blast hits to 9597 proteins in 2376 species: Archae - 34; Bacteria - 4358; Metazoa - 261; Fungi - 240; Plants - 185; Viruses - 729; Other Eukaryotes - 3795 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    8459838..8462815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_113261.4 → NP_189000.1  ribonucleotide reductase 2A [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_189000.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P50651, Q9LUH0
    UniProtKB/TrEMBL
    A0A178V929
    Conserved Domains (1) summary
    PLN02492
    Location:19 → 341
    PLN02492; ribonucleoside-diphosphate reductase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50651.2

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