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TOPII topoisomerase II [ Arabidopsis thaliana (thale cress) ]

Gene ID: 821972, updated on 18-Sep-2024

Summary

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Official Symbol
TOPII
Official Full Name
topoisomerase II
Primary source
TAIR:AT3G23890
Locus tag
AT3G23890
See related
Araport:AT3G23890
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATTOPII; topoisomerase II; TOPOISOMERASE II
Summary
Encodes a topoisomerase II that is highly expressed in young seedlings. The protein is localized in the nucleus and gene expression levels are increased in proliferative tissues.
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Genomic context

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See TOPII in Genome Data Viewer
Location:
chromosome: 3
Exon count:
20
Sequence:
Chromosome: 3; NC_003074.8 (8624636..8631392)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene GTP-binding protein-like protein Neighboring gene magnesium transporter NIPA (DUF803) Neighboring gene F-box and associated interaction domains-containing protein Neighboring gene RNA recognition motif (RRM)-containing protein Neighboring gene reverse transcriptase-like protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Role of Topoisomerase II in DNA Repair and Recombination in Arabidopsis thaliana. Martinez-Garcia M, et al. Int J Mol Sci, 2021 Dec 4. PMID 34884922, Free PMC Article
  2. Abundance of nuclear DNA topoisomerase II is correlated with proliferation in Arabidopsis thaliana. Xie S, et al. Nucleic Acids Res, 1994 Dec 25. PMID 7838729, Free PMC Article
  3. Molecular characterization of a nuclear topoisomerase II from Nicotiana tabacum that functionally complements a temperature-sensitive topoisomerase II yeast mutant. Singh BN, et al. Plant Mol Biol, 2003 Jul. PMID 14558665
  4. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Role of Topoisomerase II in DNA Repair and Recombination in Arabidopsis thaliana.
    Title: The Role of Topoisomerase II in DNA Repair and Recombination in Arabidopsis thaliana.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

NM_001125214.2
NM_113294.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP-dependent activity, acting on DNA ISS
Inferred from Sequence or Structural Similarity
more info
  
enables DNA topoisomerase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in DNA topological change IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA topological change ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within chromosome segregation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
topoisomerase II
NP_001118686.1
  • topoisomerase II (TOPII); CONTAINS InterPro DOMAIN/s: DNA topoisomerase, type IIA, subunit A/C-terminal (InterPro:IPR002205), DNA topoisomerase, type IIA, conserved site (InterPro:IPR018522), DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta (InterPro:IPR013758), DNA topoisomerase, type IIA, subunit B, domain 2 (InterPro:IPR013506), DNA topoisomerase, type IIA, subunit A, alpha-helical (InterPro:IPR013757), ATPase-like, ATP-binding domain (InterPro:IPR003594), DNA topoisomerase, type IIA, subunit B/N-terminal, alpha-beta (InterPro:IPR013759), DNA topoisomerase, type IIA, subunit B/N-terminal (InterPro:IPR001241), Ribosomal protein S5 domain 2-type fold (InterPro:IPR020568), DNA topoisomerase II, eukaryotic-type (InterPro:IPR001154), Ribosomal protein S5 domain 2-type fold, subgroup (InterPro:IPR014721), DNA topoisomerase, type IIA, central (InterPro:IPR013760); BEST Arabidopsis thaliana protein match is: DNA GYRASE B2 (TAIR:AT5G04130.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_189031.1
  • topoisomerase II (TOPII); CONTAINS InterPro DOMAIN/s: DNA topoisomerase, type IIA, subunit A/C-terminal (InterPro:IPR002205), DNA topoisomerase, type IIA, conserved site (InterPro:IPR018522), DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta (InterPro:IPR013758), DNA topoisomerase, type IIA, subunit A, alpha-helical (InterPro:IPR013757), DNA topoisomerase, type IIA, subunit B, domain 2 (InterPro:IPR013506), ATPase-like, ATP-binding domain (InterPro:IPR003594), DNA topoisomerase, type IIA, subunit B/N-terminal, alpha-beta (InterPro:IPR013759), DNA topoisomerase, type IIA, subunit B/N-terminal (InterPro:IPR001241), Ribosomal protein S5 domain 2-type fold (InterPro:IPR020568), DNA topoisomerase II, eukaryotic-type (InterPro:IPR001154), DNA topoisomerase, type IIA, central (InterPro:IPR013760); BEST Arabidopsis thaliana protein match is: DNA GYRASE B2 (TAIR:AT5G04130.1); Has 46226 Blast hits to 43639 proteins in 5982 species: Archae - 169; Bacteria - 28615; Metazoa - 2871; Fungi - 1392; Plants - 616; Viruses - 201; Other Eukaryotes - 12362 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    8624636..8631392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_113294.3 → NP_189031.1  topoisomerase II [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_189031.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P30182, Q38807
    UniProtKB/TrEMBL
    A0A178VFD9, A0A5S9XF25, A0A654FHS6
    Conserved Domains (1) summary
    PLN03237
    Location:1 → 1459
    PLN03237; DNA topoisomerase 2; Provisional

  2. NM_001125214.2 → NP_001118686.1  topoisomerase II [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001118686.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A654FHS6, B3H4G2
    Conserved Domains (6) summary
    cd03365
    Location:455 → 573
    TOPRIM_TopoIIA; TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of ...
    PLN03237
    Location:1 → 1424
    PLN03237; DNA topoisomerase 2; Provisional
    cd00187
    Location:701 → 1166
    TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA ...
    cd03481
    Location:267 → 419
    TopoIIA_Trans_ScTopoIIA; TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded ...
    pfam02518
    Location:80 → 225
    HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
    pfam16898
    Location:571 → 699
    TOPRIM_C; C-terminal associated domain of TOPRIM
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30182.2

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