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CLC-B chloride channel B [ Arabidopsis thaliana (thale cress) ]

Gene ID: 822336, updated on 18-Sep-2024

Summary

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Official Symbol
CLC-B
Official Full Name
chloride channel B
Primary source
TAIR:AT3G27170
Locus tag
AT3G27170
See related
Araport:AT3G27170
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATCLC-B; chloride channel B
Summary
member of Anion channel protein family
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Genomic context

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See CLC-B in Genome Data Viewer
Location:
chromosome: 3
Exon count:
6
Sequence:
Chromosome: 3; NC_003074.8 (10023931..10027198)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Galactose oxidase/kelch repeat superfamily protein Neighboring gene Ribosomal protein S21 family protein Neighboring gene ncRNA Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene ncRNA Neighboring gene cyclin B1 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CHLORIDE CHANNEL-b mediates vacuolar nitrate efflux to improve low nitrogen adaptation in Arabidopsis. Shi Y, et al. Plant Physiol, 2023 Oct 26. PMID 37527482
  2. CLC-b-mediated NO-3/H+ exchange across the tonoplast of Arabidopsis vacuoles. von der Fecht-Bartenbach J, et al. Plant Cell Physiol, 2010 Jun. PMID 20430762
  3. Overexpression of PP2A-C5 that encodes the catalytic subunit 5 of protein phosphatase 2A in Arabidopsis confers better root and shoot development under salt conditions. Hu R, et al. Plant Cell Environ, 2017 Jan. PMID 27676158
  4. A family of putative chloride channels from Arabidopsis and functional complementation of a yeast strain with a CLC gene disruption. Hechenberger M, et al. J Biol Chem, 1996 Dec 27. PMID 8969232
  5. Uncovering Arabidopsis membrane protein interactome enriched in transporters using mating-based split ubiquitin assays and classification models. Chen J, et al. Front Plant Sci, 2012. PMID 22737156, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CHLORIDE CHANNEL-b mediates vacuolar nitrate efflux to improve low nitrogen adaptation in Arabidopsis.
    Title: CHLORIDE CHANNEL-b mediates vacuolar nitrate efflux to improve low nitrogen adaptation in Arabidopsis.
  2. CLC-b was localized at the tonoplast, and conducted strongly outwardly rectifying anionic currents that were largest in the presence of nitrate.
    Title: CLC-b-mediated NO-3/H+ exchange across the tonoplast of Arabidopsis vacuoles.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_113631.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables monoatomic anion channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables nitrate:proton symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables voltage-gated chloride channel activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in intracellular anatomical structure TAS
Traceable Author Statement
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in plant-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
chloride channel B
NP_189353.1
  • chloride channel B (CLC-B); FUNCTIONS IN: nitrate:hydrogen symporter activity, anion channel activity, voltage-gated chloride channel activity; INVOLVED IN: chloride transport, transmembrane transport; LOCATED IN: plant-type vacuole membrane, intracellular; EXPRESSED IN: 13 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Chloride channel, core (InterPro:IPR014743), Chloride channel, voltage gated (InterPro:IPR001807), Chloride channel ClC-plant (InterPro:IPR002251), Cystathionine beta-synthase, core (InterPro:IPR000644); BEST Arabidopsis thaliana protein match is: chloride channel A (TAIR:AT5G40890.1); Has 6974 Blast hits to 6653 proteins in 1746 species: Archae - 129; Bacteria - 4490; Metazoa - 970; Fungi - 341; Plants - 365; Viruses - 0; Other Eukaryotes - 679 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    10023931..10027198
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_113631.4 → NP_189353.1  chloride channel B [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_189353.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P92942
    UniProtKB/TrEMBL
    A0A178VKG6, A0A5S9XG68, A0A7G2EQ20
    Conserved Domains (2) summary
    cd03685
    Location:54 → 575
    ClC_6_like; ClC-6-like chloride channel proteins. This CD includes ClC-6, ClC-7 and ClC-B, C, D in plants. Proteins in this family are ubiquitous in eukarotes and their functions are unclear. They are expressed in intracellular organelles membranes. This family ...
    cd04591
    Location:595 → 762
    CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P92942.1

Gene LinkOut

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