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CRK4 cysteine-rich RLK (RECEPTOR-like protein kinase) 4 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 823729, updated on 18-Sep-2024

Summary

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Official Symbol
CRK4
Official Full Name
cysteine-rich RLK (RECEPTOR-like protein kinase) 4
Primary source
TAIR:AT3G45860
Locus tag
AT3G45860
See related
Araport:AT3G45860
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
cysteine-rich RLK (RECEPTOR-like protein kinase) 4
Summary
Encodes a cysteine-rich receptor-like protein kinase. Involved in programmed cell death and defense response to pathogen.
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Genomic context

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See CRK4 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
7
Sequence:
Chromosome: 3; NC_003074.8 (16863088..16866261, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene nodulin MtN21 /EamA-like transporter family protein Neighboring gene ncRNA Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein Neighboring gene root UVB sensitive-like protein (Protein of unknown function, DUF647)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Specific control of Arabidopsis BAK1/SERK4-regulated cell death by protein glycosylation. de Oliveira MV, et al. Nat Plants, 2016 Jan 25. PMID 27250875, Free PMC Article
  2. Identification of genes encoding receptor-like protein kinases as possible targets of pathogen- and salicylic acid-induced WRKY DNA-binding proteins in Arabidopsis. Du L, et al. Plant J, 2000 Dec. PMID 11135117
  3. Enhanced Arabidopsis pattern-triggered immunity by overexpression of cysteine-rich receptor-like kinases. Yeh YH, et al. Front Plant Sci, 2015. PMID 26029224, Free PMC Article
  4. Activation of hypersensitive cell death by pathogen-induced receptor-like protein kinases from Arabidopsis. Chen K, et al. Plant Mol Biol, 2004 Sep. PMID 15604743
  5. Marker and readout genes for defense priming in Pseudomonas cannabina pv. alisalensis interaction aid understanding systemic immunity in Arabidopsis. Sistenich AJ, et al. Sci Rep, 2024 Feb 12. PMID 38347062, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_114455.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within defense response TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within defense response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within priming of cellular response to stress IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to salicylic acid IEP
Inferred from Expression Pattern
more info
 PubMed 

General protein information

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Preferred Names
cysteine-rich RLK (RECEPTOR-like protein kinase) 4
NP_190172.1
  • cysteine-rich RLK (RECEPTOR-like protein kinase) 4 (CRK4); FUNCTIONS IN: kinase activity; INVOLVED IN: defense response to bacterium, defense response, programmed cell death, response to salicylic acid stimulus; LOCATED IN: endomembrane system; EXPRESSED IN: 11 plant structures; EXPRESSED DURING: 9 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Protein of unknown function DUF26 (InterPro:IPR002902), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: cysteine-rich RLK (RECEPTOR-like protein kinase) 19 (TAIR:AT4G23270.1); Has 119379 Blast hits to 118105 proteins in 4551 species: Archae - 90; Bacteria - 13618; Metazoa - 44322; Fungi - 10003; Plants - 33611; Viruses - 380; Other Eukaryotes - 17355 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    16863088..16866261 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_114455.2 → NP_190172.1  cysteine-rich RLK (RECEPTOR-like protein kinase) 4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_190172.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LZU4
    UniProtKB/TrEMBL
    A0A5S9XJU2, A0A654FF15
    Conserved Domains (2) summary
    cd14066
    Location:357 → 625
    STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs
    pfam01657
    Location:36 → 131
    Stress-antifung; Salt stress response/antifungal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LZU4.1

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