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FK Ergosterol biosynthesis ERG4/ERG24 family [ Arabidopsis thaliana (thale cress) ]

Gene ID: 824460, updated on 18-Sep-2024

Summary

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Official Symbol
FK
Official Full Name
Ergosterol biosynthesis ERG4/ERG24 family
Primary source
TAIR:AT3G52940
Locus tag
AT3G52940
See related
Araport:AT3G52940
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ELL1; EXTRA-LONG-LIFESPAN 1; FACKEL; HYD2
Summary
Encodes a sterol C-14 reductase required for cell division and expansion and is involved in proper organization of the embryo.
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Genomic context

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Location:
chromosome: 3
Exon count:
13
Sequence:
Chromosome: 3; NC_003074.8 (19630077..19633328, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene transcriptional activator (DUF662) Neighboring gene Aldolase superfamily protein Neighboring gene Putative membrane lipoprotein Neighboring gene CBS / octicosapeptide/Phox/Bemp1 (PB1) domains-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sterols are required for cell-fate commitment and maintenance of the stomatal lineage in Arabidopsis. Qian P, et al. Plant J, 2013 Jun. PMID 23551583
  2. A critical role of sterols in embryonic patterning and meristem programming revealed by the fackel mutants of Arabidopsis thaliana. Jang JC, et al. Genes Dev, 2000 Jun 15. PMID 10859167, Free PMC Article
  3. FACKEL is a sterol C-14 reductase required for organized cell division and expansion in Arabidopsis embryogenesis. Schrick K, et al. Genes Dev, 2000 Jun 15. PMID 10859166, Free PMC Article
  4. Fackel interacts with gibberellic acid signaling and vernalization to mediate flowering in Arabidopsis. Huang B, et al. Planta, 2017 May. PMID 28108812
  5. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

NM_115154.3
NM_202691.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables NADP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables delta14-sterol reductase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables delta14-sterol reductase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within embryo development ending in seed dormancy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sterol biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Ergosterol biosynthesis ERG4/ERG24 family
NP_566975.1
  • FACKEL (FK); FUNCTIONS IN: delta14-sterol reductase activity; INVOLVED IN: sterol biosynthetic process, embryo development ending in seed dormancy; LOCATED IN: endomembrane system, membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Sterol reductase, conserved site (InterPro:IPR018083), Ergosterol biosynthesis ERG4/ERG24 (InterPro:IPR001171); BEST Arabidopsis thaliana protein match is: Ergosterol biosynthesis ERG4/ERG24 family (TAIR:AT1G50430.2); Has 1188 Blast hits to 1183 proteins in 251 species: Archae - 2; Bacteria - 118; Metazoa - 269; Fungi - 413; Plants - 205; Viruses - 3; Other Eukaryotes - 178 (source: NCBI BLink).
NP_974420.1
  • FACKEL (FK); FUNCTIONS IN: delta14-sterol reductase activity; INVOLVED IN: sterol biosynthetic process, embryo development ending in seed dormancy; LOCATED IN: endomembrane system, membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Sterol reductase, conserved site (InterPro:IPR018083), Ergosterol biosynthesis ERG4/ERG24 (InterPro:IPR001171); BEST Arabidopsis thaliana protein match is: Ergosterol biosynthesis ERG4/ERG24 family (TAIR:AT1G50430.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    19630077..19633328 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_115154.3 → NP_566975.1  Ergosterol biosynthesis ERG4/ERG24 family [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_566975.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LD62, Q9LDR4
    UniProtKB/TrEMBL
    A0A654FGX0, A0A7G2EWX1, Q0WUH0
    Conserved Domains (1) summary
    cl21511
    Location:4 → 369
    PEMT; Phospholipid methyltransferase

  2. NM_202691.1 → NP_974420.1  Ergosterol biosynthesis ERG4/ERG24 family [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_974420.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F4J859
    Conserved Domains (1) summary
    cl21511
    Location:4 → 229
    PEMT; Phospholipid methyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LDR4.2

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