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ACS1 ACC synthase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 825324, updated on 18-Sep-2024

Summary

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Official Symbol
ACS1
Official Full Name
ACC synthase 1
Primary source
TAIR:AT3G61510
Locus tag
AT3G61510
See related
Araport:AT3G61510
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE 1; ACC synthase 1; ARABIDOPSIS THALIANA 1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE 1; AT-ACS1
Summary
Encodes a member of the 1-aminocyclopropane-1-carboxylate (ACC) synthase (S-adenosyl-L-methionine methylthioadenosine-lyase, EC 4.4.1.14) gene family. The gene is transcriptionally active but enzymatically inactive. The predicted amino-acid sequence of ACS1 is missing the highly conserved tripeptide, Thr-Asn-Pro (TNP), between Ile204 and Ser205. Introduction of TNP into ACS1 restores the ACS activity.
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Genomic context

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See ACS1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
4
Sequence:
Chromosome: 3; NC_003074.8 (22763495..22766010, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Pectin lyase-like superfamily protein Neighboring gene BPS1-like protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene Phosphoenolpyruvate carboxylase family protein Neighboring gene alpha/beta-Hydrolases superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The dependence of leaf senescence on the balance between 1-aminocyclopropane-1-carboxylate acid synthase 1 (ACS1)-catalysed ACC generation and nitric oxide-associated 1 (NOS1)-dependent NO accumulation in Arabidopsis. Lv SF, et al. Plant Biol (Stuttg), 2019 Jul. PMID 30734982
  2. Characterization of two members (ACS1 and ACS3) of the 1-aminocyclopropane-1-carboxylate synthase gene family of Arabidopsis thaliana. Liang X, et al. Gene, 1995 Dec 29. PMID 8566772
  3. Heterodimeric interactions among the 1-amino-cyclopropane-1-carboxylate synthase polypeptides encoded by the Arabidopsis gene family. Tsuchisaka A, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983000, Free PMC Article
  4. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. activity corresponds to the onset of leaf senescence
    Title: The dependence of leaf senescence on the balance between 1-aminocyclopropane-1-carboxylate acid synthase 1 (ACS1)-catalysed ACC generation and nitric oxide-associated 1 (NOS1)-dependent NO accumulation in Arabidopsis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_116016.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
NOT enables 1-aminocyclopropane-1-carboxylate synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
NOT involved_in ethylene biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
ACC synthase 1
NP_191710.1
  • ACC synthase 1 (ACS1); CONTAINS InterPro DOMAIN/s: 1-aminocyclopropane-1-carboxylate synthase (InterPro:IPR001176), Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Aminotransferase, class I/classII (InterPro:IPR004839), Aminotransferases, class-I, pyridoxal-phosphate-binding site (InterPro:IPR004838), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (InterPro:IPR015422); BEST Arabidopsis thaliana protein match is: 1-amino-cyclopropane-1-carboxylate synthase 2 (TAIR:AT1G01480.1); Has 22999 Blast hits to 22998 proteins in 2818 species: Archae - 808; Bacteria - 15898; Metazoa - 560; Fungi - 631; Plants - 1241; Viruses - 0; Other Eukaryotes - 3861 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    22763495..22766010 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_116016.2 → NP_191710.1  ACC synthase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_191710.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q06429, Q43368, Q9S9C6
    UniProtKB/TrEMBL
    A0A654FJS5
    Conserved Domains (3) summary
    cd00609
    Location:89 → 427
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
    PLN02994
    Location:3 → 154
    PLN02994; 1-aminocyclopropane-1-carboxylate synthase
    PLN02376
    Location:4 → 488
    PLN02376; 1-aminocyclopropane-1-carboxylate synthase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06429.2

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