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AUD1 NAD(P)-binding Rossmann-fold superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 825458, updated on 18-Sep-2024

Summary

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Official Symbol
AUD1
Official Full Name
NAD(P)-binding Rossmann-fold superfamily protein
Primary source
TAIR:AT3G62830
Locus tag
AT3G62830
See related
Araport:AT3G62830
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATUXS2; UDP-GLUCURONIC ACID DECARBOXYLASE 2; UXS2
Summary
encodes an isoform of UDP-glucuronic acid decarboxylase, which is predicted to be membrane-bound by PSORT. This enzyme produces UDP-xylose, which is a substrate for many cell wall carbohydrates including hemicellulose and pectin. UDP-xylose is also known to feedback regulate several cell wall biosynthetic enzymes.
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Genomic context

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See AUD1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
7
Sequence:
Chromosome: 3; NC_003074.8 (23232272..23235567)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene complex 1 family protein / LVR family protein Neighboring gene Plant invertase/pectin methylesterase inhibitor superfamily protein Neighboring gene ncRNA Neighboring gene Small nuclear ribonucleoprotein family protein Neighboring gene zinc finger protein-like protein Neighboring gene alpha/beta-Hydrolases superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular genetics of nucleotide sugar interconversion pathways in plants. Reiter WD, et al. Plant Mol Biol, 2001 Sep. PMID 11554483
  2. Biosynthesis of UDP-xylose: characterization of membrane-bound AtUxs2. Pattathil S, et al. Planta, 2005 Jun. PMID 15655675
  3. Biosynthesis of UDP-xylose. Cloning and characterization of a novel Arabidopsis gene family, UXS, encoding soluble and putative membrane-bound UDP-glucuronic acid decarboxylase isoforms. Harper AD, et al. Plant Physiol, 2002 Dec. PMID 12481102, Free PMC Article
  4. Role of UDP-Glucuronic Acid Decarboxylase in Xylan Biosynthesis in Arabidopsis. Kuang B, et al. Mol Plant, 2016 Aug 1. PMID 27179920
  5. Label-free protein quantification for plant Golgi protein localization and abundance. Nikolovski N, et al. Plant Physiol, 2014 Oct. PMID 25122472, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001125421.1
NM_116148.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables NAD+ binding IEA
Inferred from Electronic Annotation
more info
  
enables UDP-glucuronate decarboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dTDP-glucose 4,6-dehydratase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within D-xylose metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in D-xylose metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in UDP-D-xylose biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within dTDP-rhamnose biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus HDA PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus ISM
Inferred from Sequence Model
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi trans cisterna HDA PubMed 
NOT located_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in endosome HDA PubMed 
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in plasma membrane HDA PubMed 
located_in trans-Golgi network HDA PubMed 

General protein information

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Preferred Names
NAD(P)-binding Rossmann-fold superfamily protein
NP_001118893.1
  • UDP-GLUCURONIC ACID DECARBOXYLASE 2 (UXS2); FUNCTIONS IN: UDP-glucuronate decarboxylase activity, dTDP-glucose 4,6-dehydratase activity, catalytic activity; INVOLVED IN: dTDP-rhamnose biosynthetic process, nucleotide-sugar metabolic process, D-xylose metabolic process; LOCATED IN: plasma membrane, Golgi membrane, membrane; EXPRESSED IN: guard cell, cultured cell; CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: UDP-xylose synthase 4 (TAIR:AT2G47650.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_191842.1
  • AUD1; FUNCTIONS IN: UDP-glucuronate decarboxylase activity, dTDP-glucose 4,6-dehydratase activity, catalytic activity; INVOLVED IN: dTDP-rhamnose biosynthetic process, nucleotide-sugar metabolic process, D-xylose metabolic process; LOCATED IN: plasma membrane, Golgi membrane, membrane; EXPRESSED IN: guard cell, cultured cell; CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: UDP-xylose synthase 4 (TAIR:AT2G47650.1); Has 44607 Blast hits to 44567 proteins in 3006 species: Archae - 852; Bacteria - 26090; Metazoa - 741; Fungi - 328; Plants - 1343; Viruses - 47; Other Eukaryotes - 15206 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    23232272..23235567
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_116148.3 → NP_191842.1  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_191842.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q39077, Q9LZI2
    UniProtKB/TrEMBL
    A0A178VKB0, A0A5S9XNX2
    Conserved Domains (1) summary
    PLN02206
    Location:1 → 432
    PLN02206; UDP-glucuronate decarboxylase

  2. NM_001125421.1 → NP_001118893.1  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001118893.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q39077, Q9LZI2
    UniProtKB/TrEMBL
    A0A178VKB0, A0A5S9XNX2
    Conserved Domains (1) summary
    PLN02206
    Location:1 → 432
    PLN02206; UDP-glucuronate decarboxylase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LZI2.1

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