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CBL5 calcineurin B-like protein 5 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 826671, updated on 18-Sep-2024

Summary

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Official Symbol
CBL5
Official Full Name
calcineurin B-like protein 5
Primary source
TAIR:AT4G01420
Locus tag
AT4G01420
See related
Araport:AT4G01420
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
calcineurin B-like protein 5; F3D13.2; F3D13_2
Summary
Encodes calcineurin B-like protein 5 (CBL5). Overexpression confers tolerance to drought and salt stress.
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Genomic context

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See CBL5 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
7
Sequence:
Chromosome: 4; NC_003075.7 (580038..581521, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene conserved oligomeric Golgi complex subunit 4 Neighboring gene oligomeric golgi complex subunit-like protein Neighboring gene Late embryogenesis abundant (LEA) hydroxyproline-rich glycoprotein family Neighboring gene miscRNA Neighboring gene nodulin MtN21 /EamA-like transporter family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Constitutive overexpression of the calcium sensor CBL5 confers osmotic or drought stress tolerance in Arabidopsis. Cheong YH, et al. Mol Cells, 2010 Feb 28. PMID 20077023
  2. N-myristoylation and S-acylation are common modifications of Ca(2+) -regulated Arabidopsis kinases and are required for activation of the SLAC1 anion channel. Saito S, et al. New Phytol, 2018 Jun. PMID 29498046
  3. Calcineurin B-like protein CBL10 directly interacts with AKT1 and modulates K+ homeostasis in Arabidopsis. Ren XL, et al. Plant J, 2013 Apr. PMID 23331977
  4. CBL-mediated targeting of CIPKs facilitates the decoding of calcium signals emanating from distinct cellular stores. Batistic O, et al. Plant J, 2010 Jan. PMID 19832944
  5. A protein kinase, calcineurin B-like protein-interacting protein Kinase9, interacts with calcium sensor calcineurin B-like Protein3 and regulates potassium homeostasis under low-potassium stress in Arabidopsis. Liu LL, et al. Plant Physiol, 2013 Jan. PMID 23109687, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SLAC1 activation by CPK6 or CBL5-CIPK11 was strictly dependent on dual lipid modification.
    Title: N-myristoylation and S-acylation are common modifications of Ca(2+) -regulated Arabidopsis kinases and are required for activation of the SLAC1 anion channel.
  2. These results suggest that CBL5 may function as a positive regulator of salt or drought responses in plants.
    Title: Constitutive overexpression of the calcium sensor CBL5 confers osmotic or drought stress tolerance in Arabidopsis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001340311.1
NM_116372.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables kinase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within calcium-mediated signaling TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within response to osmotic stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to salt stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to water deprivation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
calcineurin B-like protein 5
NP_192051.2
  • calcineurin B-like protein 5 (CBL5); FUNCTIONS IN: calcium ion binding; INVOLVED IN: response to salt stress, response to water deprivation, N-terminal protein myristoylation, calcium-mediated signaling, response to osmotic stress; LOCATED IN: cellular_component unknown; EXPRESSED IN: stem, flower, leaf; CONTAINS InterPro DOMAIN/s: Recoverin (InterPro:IPR001125), EF-HAND 2 (InterPro:IPR018249), Calcineurin B protein (InterPro:IPR015757), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048); BEST Arabidopsis thaliana protein match is: Calcium-binding EF-hand family protein (TAIR:AT5G24270.2); Has 5545 Blast hits to 5527 proteins in 657 species: Archae - 0; Bacteria - 7; Metazoa - 2787; Fungi - 925; Plants - 1302; Viruses - 0; Other Eukaryotes - 524 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    580038..581521 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_116372.3 → NP_192051.2  calcineurin B-like protein 5 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_192051.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O81328, Q7FZF1
    Conserved Domains (1) summary
    COG5126
    Location:13 → 181
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  2. NM_001340311.1 → NP_001329076.1  calcineurin B-like protein 5 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UXP4, A0A1P8B6M3, A0A384KKX9
    Conserved Domains (1) summary
    COG5126
    Location:13 → 181
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7FZF1.3

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