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MS5 Tetratricopeptide repeat (TPR)-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 827838, updated on 18-Sep-2024

Summary

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Official Symbol
MS5
Official Full Name
Tetratricopeptide repeat (TPR)-like superfamily protein
Primary source
TAIR:AT4G20900
Locus tag
AT4G20900
See related
Araport:AT4G20900
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
MALE-STERILE 5; T13K14.60; T13K14_60; TDM1
Summary
ms5 mutants are male sterile, pollen tetrads undergo an extra round of division after meiosis II without chromosome replication, resulting in chromosome abnormalities. Gene product has some similarity to SCP1, a rat synaptonemal complex protein.
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Genomic context

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See MS5 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
5
Sequence:
Chromosome: 4; NC_003075.7 (11184103..11185844, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene ethylene-responsive nuclear protein / ethylene-regulated nuclear protein (ERT2) Neighboring gene tubulin beta-9 chain Neighboring gene double-stranded RNA binding protein-related / DsRBD protein-like protein Neighboring gene double-stranded RNA-binding domain (DsRBD)-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Meiotic exit in Arabidopsis is driven by P-body-mediated inhibition of translation. Cairo A, et al. Science, 2022 Aug 5. PMID 35926014
  2. Structural analysis of the meiosis-related protein MS5 reveals non-canonical papain enhancement by cystatin-like folds. Wang X, et al. FEBS Lett, 2020 Aug. PMID 32415887
  3. TDM1 Regulation Determines the Number of Meiotic Divisions. Cifuentes M, et al. PLoS Genet, 2016 Feb. PMID 26871453, Free PMC Article
  4. The Chromatin Protein DUET/MMD1 Controls Expression of the Meiotic Gene TDM1 during Male Meiosis in Arabidopsis. Andreuzza S, et al. PLoS Genet, 2015 Sep. PMID 26348709, Free PMC Article
  5. Cloning and characterization of MS5 from Arabidopsis: a gene critical in male meiosis. Glover J, et al. Plant J, 1998 Aug. PMID 9750346

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Meiotic exit in Arabidopsis is driven by P-body-mediated inhibition of translation.
    Title: Meiotic exit in Arabidopsis is driven by P-body-mediated inhibition of translation.
  2. Structural analysis of the meiosis-related protein MS5 reveals non-canonical papain enhancement by cystatin-like folds.
    Title: Structural analysis of the meiosis-related protein MS5 reveals non-canonical papain enhancement by cystatin-like folds.
  3. TDM1 is an APC/C component whose function is to ensure meiosis termination.
    Title: TDM1 Regulation Determines the Number of Meiotic Divisions.
  4. identify two genes TDM1 and JAS with critical functions in cell cycle transitions and spindle organization in male meiosis, as DUET targets, with TDM1 being a direct target
    Title: The Chromatin Protein DUET/MMD1 Controls Expression of the Meiotic Gene TDM1 during Male Meiosis in Arabidopsis.
  5. Results propose a model that meiotic progression in Arabidopsis pollen mother cells is driven by a yet to be identified cyclin-CDK activity that is modulated by regulatory interactions between TDM1, SMG7, and TAM (CYCA1;2)
    Title: Meiotic progression in Arabidopsis is governed by complex regulatory interactions between SMG7, TDM1, and the meiosis I-specific cyclin TAM.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in male meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within microsporogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microsporogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in P-body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Tetratricopeptide repeat (TPR)-like superfamily protein
NP_193822.1
  • MALE-STERILE 5 (MS5); BEST Arabidopsis thaliana protein match is: Tetratricopeptide repeat (TPR)-like superfamily protein (TAIR:AT5G44330.1); Has 181 Blast hits to 179 proteins in 26 species: Archae - 0; Bacteria - 4; Metazoa - 2; Fungi - 0; Plants - 166; Viruses - 5; Other Eukaryotes - 4 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    11184103..11185844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001341460.1 → NP_001328331.1  Tetratricopeptide repeat (TPR)-like superfamily protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O65310, Q9SBJ5, Q9SUC3
    UniProtKB/TrEMBL
    A0A178V3U6, A0A7G2F4R7
    Conserved Domains (2) summary
    COG0457
    Location:97 → 277
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:190 → 220
    TPR; TPR repeat [structural motif]

  2. NM_118208.1 → NP_193822.1  Tetratricopeptide repeat (TPR)-like superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_193822.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5S9XUA8, A0A7G2F4R7
    Conserved Domains (1) summary
    sd00006
    Location:190 → 236
    TPR; TPR repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SUC3.2

Gene LinkOut

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