FZR2 FIZZY-related 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: FZR2
Official Full Name: FIZZY-related 2
Primary source: TAIR:AT4G22910
Locus tag: AT4G22910
See related: Araport:AT4G22910
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: CCS52A1; cell cycle switch protein 52 A1; cell cycle switch protein 52 A1; F7H19.90; F7H19_90; FIZZY-related 2
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Genomic context

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See FZR2 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 8

Sequence:: Chromosome: 4; NC_003075.7 (12012408..12016012)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The data illustrate cooperative activity of the APC/C(CCS52A1) and APC/C(CCS52A2) complexes during root and trichome development, but functional interdependency during leaf development. Furthermore, we found APC/C(CCS52A1) activity to control CCS52A2 expression. We conclude that interdependency of CCS52A-controlled APC/C activity is controlled in a tissue-specific manner.
Title: Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
Findings support both complementary and dose-dependent actions for the Arabidopsis CCS52A isoforms in plant development and demonstrate that elevated ectopic CCS52A expression positively correlates with organ size, opening a route to higher biomass production. [CCS52A1]
Title: Complementary and dose-dependent action of AtCCS52A isoforms in endoreduplication and plant size control.
Down-regulation and over-expression of CCS52 and DEL1 in Arabidopsis affected giant cell and syncytium growth, resulting in restrained nematode development, illustrating the need for mitotic activity and endo-reduplication for feeding site maturation.
Title: CCS52 and DEL1 genes are key components of the endocycle in nematode-induced feeding sites.
CCS52A1 and SIM cooperate in repressing accumulation of mitotic cyclins to establish the trichome endocycle.
Title: SIAMESE cooperates with the CDH1-like protein CCS52A1 to establish endoreplication in Arabidopsis thaliana trichomes.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_118420.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables anaphase-promoting complex binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-protein transferase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA endoreduplication	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multidimensional cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within trichome branching	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: FIZZY-related 2

NP_194022.3

FIZZY-related 2 (FZR2); FUNCTIONS IN: signal transducer activity; INVOLVED IN: trichome branching, signal transduction, DNA endoreduplication, cell growth; LOCATED IN: chloroplast, heterotrimeric G-protein complex; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40 repeat, conserved site (InterPro:IPR019775), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat (InterPro:IPR001680), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: cell cycle switch protein 52 A2 (TAIR:AT4G11920.1); Has 43458 Blast hits to 22953 proteins in 693 species: Archae - 46; Bacteria - 6865; Metazoa - 16440; Fungi - 9775; Plants - 5102; Viruses - 0; Other Eukaryotes - 5230 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

12012408..12016012

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_118420.5 → NP_194022.3 FIZZY-related 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_194022.3

Status: REVIEWED

UniProtKB/Swiss-Prot

O82740, Q8L3Z8

UniProtKB/TrEMBL

A0A178V5I2, A0A5S9XUZ4

Conserved Domains (2) summary

sd00039
Location:220 → 257

7WD40; WD40 repeat [structural motif]

cl29593
Location:182 → 458

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...