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CYCB1;1 CYCLIN B1;1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 829904, updated on 18-Sep-2024

Summary

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Official Symbol
CYCB1;1
Official Full Name
CYCLIN B1;1
Primary source
TAIR:AT4G37490
Locus tag
AT4G37490
See related
Araport:AT4G37490
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
CYC1; CYCB1; CYCLIN 1; CYCLIN B1;1; F6G17.140; F6G17_140
Summary
Cyclin-dependent protein kinase CYCB1;1. Functions as an effector of growth control at G2/M. Regulated by TCP20.
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Genomic context

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See CYCB1;1 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
8
Sequence:
Chromosome: 4; NC_003075.7 (17621886..17624308, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene Chaperone DnaJ-domain superfamily protein Neighboring gene uncharacterized protein Neighboring gene Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding protein Neighboring gene Ribonuclease III family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. B1-type cyclins control microtubule organization during cell division in Arabidopsis. Romeiro Motta M, et al. EMBO Rep, 2022 Jan 5. PMID 34882930, Free PMC Article
  2. ANAPHASE PROMOTING COMPLEX/CYCLOSOME-mediated cyclin B1 degradation is critical for cell cycle synchronization in syncytial endosperms. Guo L, et al. J Integr Plant Biol, 2018 Jun. PMID 29424475
  3. The APC/C subunit 10 plays an essential role in cell proliferation during leaf development. Eloy NB, et al. Plant J, 2011 Oct. PMID 21711400
  4. Overexpression of the Arabidopsis anaphase promoting complex subunit CDC27a increases growth rate and organ size. Rojas CA, et al. Plant Mol Biol, 2009 Oct. PMID 19629716
  5. Arabidopsis TCP20 links regulation of growth and cell division control pathways. Li C, et al. Proc Natl Acad Sci U S A, 2005 Sep 6. PMID 16123132, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. B1-type cyclins control microtubule organization during cell division in Arabidopsis.
    Title: B1-type cyclins control microtubule organization during cell division in Arabidopsis.
  2. APC/C-mediated cyclin B1 degradation is critical for cell cycle synchronization.
    Title: ANAPHASE PROMOTING COMPLEX/CYCLOSOME-mediated cyclin B1 degradation is critical for cell cycle synchronization in syncytial endosperms.
  3. The authors identify the plant-specific B1-type CDKs (CDKB1s) and the class of B1-type cyclins (CYCB1s) as major regulators of homology-dependent repair in plants.
    Title: The plant-specific CDKB1-CYCB1 complex mediates homologous recombination repair in Arabidopsis.
  4. The increased leaf size was found to be due to enhanced rates of cell division during the early stages of leaf development and by increased APC/C activity as measured by an amplification of the proteolysis rate of the mitotic cyclin, CYCB1;1.
    Title: The APC/C subunit 10 plays an essential role in cell proliferation during leaf development.
  5. APC/C is an integrator that regulates both microRNA-mediated transcriptional regulation of CYCB1;1 and degradation of CYCB1;1.
    Title: The anaphase-promoting complex is a dual integrator that regulates both MicroRNA-mediated transcriptional regulation of cyclin B1 and degradation of Cyclin B1 during Arabidopsis male gametophyte development.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_119913.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitotic cell cycle phase transition IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to gamma radiation IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
CYCLIN B1;1
NP_195465.1
  • CYCLIN B1;1 (CYCB1;1); FUNCTIONS IN: cyclin-dependent protein kinase regulator activity; INVOLVED IN: regulation of cell cycle, regulation of cell growth, response to gamma radiation; LOCATED IN: nucleus; EXPRESSED IN: 17 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Cyclin, C-terminal (InterPro:IPR004367), Cyclin-like (InterPro:IPR011028), Cyclin-related (InterPro:IPR013763), Cyclin, N-terminal (InterPro:IPR006671), Cyclin, A/B/D/E (InterPro:IPR014400), Cyclin (InterPro:IPR006670); BEST Arabidopsis thaliana protein match is: Cyclin family protein (TAIR:AT5G06150.1); Has 4378 Blast hits to 4375 proteins in 374 species: Archae - 0; Bacteria - 2; Metazoa - 1992; Fungi - 556; Plants - 1161; Viruses - 34; Other Eukaryotes - 633 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    17621886..17624308 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_119913.3 → NP_195465.1  CYCLIN B1;1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_195465.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P30183, Q08A73, Q42081
    UniProtKB/TrEMBL
    A0A178UZN5, A0A5S9XZG3
    Conserved Domains (2) summary
    cd20511
    Location:295 → 417
    CYCLIN_AtCycB-like_rpt2; second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins
    cd20567
    Location:145 → 290
    CYCLIN_AtCycB-like_rpt1; first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30183.2

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