MTN1 methylthioadenosine nucleosidase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: MTN1
Official Full Name: methylthioadenosine nucleosidase 1
Primary source: TAIR:AT4G38800
Locus tag: AT4G38800
See related: Araport:AT4G38800
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS METHYLTHIOADENOSINE NUCLEOSIDASE 1; ATMTAN1; ATMTN1; methylthioadenosine nucleosidase 1; METHYLTHIOADENOSINE NUCLEOSIDASE 1; MTAN1; T9A14.80; T9A14_80
Summary: Encodes one of the 5'-methylthioadenosine nucleosidases (AT4G38800/MTN1; AT4G34840/MTN2). Double mutant, mtn1-1mtn2-1, retains approximately 14% of the MTN enzyme activity present in the wild type and displays a pleiotropic phenotype that includes altered vasculature and impaired fertility.
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Genomic context

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See MTN1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 8

Sequence:: Chromosome: 4; NC_003075.7 (18113161..18115176, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MTA as a crucial metabolite that acts as a regulatory link between the Yang cycle and polyamine biosynthesis and identifies MTA nucleosidase as a crucial enzyme of the Yang cycle. [MTN1]
Title: Inhibition of 5'-methylthioadenosine metabolism in the Yang cycle alters polyamine levels, and impairs seedling growth and reproduction in Arabidopsis.
a structural comparison of AtMTAN2 performed with previously determined structures of AtMTAN1 and an E. coli homolog provides clues for the substrate specificity of MTA nucleosidases in A. thaliana.
Title: Biochemical and structural characterization of 5'-methylthioadenosine nucleosidases from Arabidopsis thaliana.
The ATMTN1 protein methylthioadenosine nucleosidase activity can be inhibited specifically by Ca(2+)-bound CBL3.
Title: The Arabidopsis calcium sensor calcineurin B-like 3 inhibits the 5'-methylthioadenosine nucleosidase in a calcium-dependent manner.
AtMTAN1 was characterized kinetically.
Title: Molecular determinants of substrate specificity in plant 5'-methylthioadenosine nucleosidases.
determined the high-resolution structure of 5'-methylthioadenosine nucleosidase from Arabidopsis thaliana (AtMTAN)
Title: Crystal structure of 5'-methylthioadenosine nucleosidase from Arabidopsis thaliana at 1.5-A resolution.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_120040.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables methylthioadenosine nucleosidase activity	IDA Inferred from Direct Assay more info	PubMed
enables methylthioadenosine nucleosidase activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within L-methionine salvage from methylthioadenosine	IDA Inferred from Direct Assay more info	PubMed
involved_in L-methionine salvage from methylthioadenosine	IEA Inferred from Electronic Annotation more info
involved_in nucleoside metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phloem or xylem histogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within reproductive process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytosol	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed

General protein information

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Preferred Names: methylthioadenosine nucleosidase 1

NP_195591.1

methylthioadenosine nucleosidase 1 (MTN1); FUNCTIONS IN: catalytic activity, methylthioadenosine nucleosidase activity; INVOLVED IN: L-methionine salvage from methylthioadenosine, nucleoside metabolic process; LOCATED IN: plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Nucleoside phosphorylase (InterPro:IPR000845), Nucleoside phosphorylase, family 1 (InterPro:IPR018017); BEST Arabidopsis thaliana protein match is: Phosphorylase superfamily protein (TAIR:AT4G34840.1); Has 2898 Blast hits to 2898 proteins in 1272 species: Archae - 0; Bacteria - 2765; Metazoa - 0; Fungi - 0; Plants - 81; Viruses - 0; Other Eukaryotes - 52 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

18113161..18115176 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_120040.4 → NP_195591.1 methylthioadenosine nucleosidase 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_195591.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9T0I8

UniProtKB/TrEMBL

A0A178UXV8, A0A5S9XZW6

Conserved Domains (1) summary

PLN02584
Location:19 → 267

PLN02584; 5'-methylthioadenosine nucleosidase