BRI1 Leucine-rich receptor-like protein kinase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: BRI1
Official Full Name: Leucine-rich receptor-like protein kinase family protein
Primary source: TAIR:AT4G39400
Locus tag: AT4G39400
See related: Araport:AT4G39400
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATBRI1; BIN1; BR INSENSITIVE 1; BRASSINOSTEROID INSENSITIVE 1; CABBAGE 2; CBB2; DWARF 2; DWF2; F23K16.30; F23K16_30
Summary: Encodes a plasma membrane localized leucine-rich repeat receptor kinase involved in brassinosteroid signal transduction. BRI1 ligand is brassinolide which binds at the extracellular domain. Binding results in phosphorylation of the kinase domain which activates the BRI1 protein leading to BR responses. Residue T-1049 and either S-1044 or T-1045 were essential for kinase function in vitro and normal BRI1 signaling in planta. The structure of BRI1 ligand-binding domain has been determined at 2.5A resolution. Although BAK1 and BRI1 alone localize in the plasma membrane, when BAK1 and BRI1 are coexpressed, the heterodimer BAK1/BRI1 they form is localized in the endosome. BRI1 appears to be involved in the autonomous pathway that regulates the transition to flowering, primarily through its effects on FLC expression levels, as uncovered by double mutant analyses. This most likely occurs as a result of BRI1-dependent effects on histone acetylation, but not histone triMeH3K4 methylation, at the FLC locus.
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Genomic context

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See BRI1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 1

Sequence:: Chromosome: 4; NC_003075.7 (18324457..18328831)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The brassinosteroid receptor gene BRI1 safeguards cell-autonomous brassinosteroid signaling across tissues.
Title: The brassinosteroid receptor gene BRI1 safeguards cell-autonomous brassinosteroid signaling across tissues.
R-SNARE protein YKT61 mediates root apical meristem cell division via BRASSINOSTEROID-INSENSITIVE1 recycling.
Title: R-SNARE protein YKT61 mediates root apical meristem cell division via BRASSINOSTEROID-INSENSITIVE1 recycling.
BRASSINOSTEROID INSENSITIVE1 internalization can occur independent of ligand binding.
Title: BRASSINOSTEROID INSENSITIVE1 internalization can occur independent of ligand binding.
Chemical control of receptor kinase signaling by rapamycin-induced dimerization.
Title: Chemical control of receptor kinase signaling by rapamycin-induced dimerization.
PIN-LIKES Coordinate Brassinosteroid Signaling with Nuclear Auxin Input in Arabidopsis thaliana.
Title: PIN-LIKES Coordinate Brassinosteroid Signaling with Nuclear Auxin Input in Arabidopsis thaliana.
Endocytosis of BRASSINOSTEROID INSENSITIVE1 Is Partly Driven by a Canonical Tyr-Based Motif.
Title: Endocytosis of BRASSINOSTEROID INSENSITIVE1 Is Partly Driven by a Canonical Tyr-Based Motif.
A defect in BRI1-EMS-SUPPRESSOR 1 (bes1)-mediated brassinosteroid signaling increases photoinhibition and photo-oxidative stress during heat stress in Arabidopsis.
Title: A defect in BRI1-EMS-SUPPRESSOR 1 (bes1)-mediated brassinosteroid signaling increases photoinhibition and photo-oxidative stress during heat stress in Arabidopsis.
BZR1 Family Transcription Factors Function Redundantly and Indispensably in BR Signaling but Exhibit BRI1-Independent Function in Regulating Anther Development in Arabidopsis
Title: BZR1 Family Transcription Factors Function Redundantly and Indispensably in BR Signaling but Exhibit BRI1-Independent Function in Regulating Anther Development in Arabidopsis.
the functional importance of critical Cys residues in stabilizing the superhelical conformation of BRI1-leucine-rich-repeat, is reported.
Title: Identification of critical cysteine sites in brassinosteroid-insensitive 1 and novel signaling regulators using a transient expression system.
Q-SNARE SYP22 and R-SNARE VAMP727 mediate the BRI trafficking to plasma membrane.
Title: SYP22 and VAMP727 regulate BRI1 plasma membrane targeting to control plant growth in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_120100.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables SNARE binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables steroid binding	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anther wall tapetum cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within brassinosteroid homeostasis	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within brassinosteroid mediated signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within brassinosteroid mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within detection of brassinosteroid stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within leaf development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pollen exine formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of flower development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to UV-B	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to water deprivation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in seedling development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within unidimensional cell growth	IMP Inferred from Mutant Phenotype more info

Component	Evidence Code	Pubs
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISM Inferred from Sequence Model more info
part_of protein-containing complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: Leucine-rich receptor-like protein kinase family protein

NP_195650.1

BRASSINOSTEROID INSENSITIVE 1 (BRI1); FUNCTIONS IN: in 6 functions; INVOLVED IN: in 9 processes; LOCATED IN: endosome, plasma membrane, protein complex; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: BRI1 like (TAIR:AT1G55610.2); Has 214988 Blast hits to 139206 proteins in 4645 species: Archae - 193; Bacteria - 21464; Metazoa - 65624; Fungi - 10774; Plants - 90532; Viruses - 410; Other Eukaryotes - 25991 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

18324457..18328831

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_120100.3 → NP_195650.1 Leucine-rich receptor-like protein kinase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_195650.1

Status: REVIEWED

UniProtKB/Swiss-Prot

C0LGS4, O22476

UniProtKB/TrEMBL

A0A178USG5, A0A5S9Y018

Conserved Domains (2) summary

PLN00113
Location:35 → 1146

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:367 → 391

LRR_RI; leucine-rich repeat [structural motif]