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ML4 MEI2-like 4 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 830620, updated on 18-Sep-2024

Summary

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Official Symbol
ML4
Official Full Name
MEI2-like 4
Primary source
TAIR:AT5G07290
Locus tag
AT5G07290
See related
Araport:AT5G07290
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AML4; MEI2-like 4; T28J14.230; T28J14_230
Summary
AML4 A member of mei2-like gene family, predominantly plant-based family of genes encoding RNA binding proteins with characteristic presence of a highly conserved RNA binding motif first described in the mei2 gene of the fission yeast S. pombe. In silico analyses reveal nine mei2 -like genes in A. thaliana. They were grouped into four distinct clades, based on overall sequence similarity and subfamily-specific sequence elements. AML4 is a member of two sister clades of mei2-like gene family, AML1 through AML5, and belongs to the clade named ALM14. AML4 is expressed during embryo development (heart and torpedo stage) and in vegetative and floral apices.
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Genomic context

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See ML4 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
14
Sequence:
Chromosome: 5; NC_003076.8 (2293114..2298976)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Leucine-rich repeat transmembrane protein kinase Neighboring gene ncRNA Neighboring gene Calcium-dependent phospholipid-binding Copine family protein Neighboring gene Integrase-type DNA-binding superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Arabidopsis-mei2-like genes play a role in meiosis and vegetative growth in Arabidopsis. Kaur J, et al. Plant Cell, 2006 Mar. PMID 16473967, Free PMC Article
  2. PLASTOCHRON2 regulates leaf initiation and maturation in rice. Kawakatsu T, et al. Plant Cell, 2006 Mar. PMID 16461585, Free PMC Article
  3. In Planta Determination of the mRNA-Binding Proteome of Arabidopsis Etiolated Seedlings. Reichel M, et al. Plant Cell, 2016 Oct. PMID 27729395, Free PMC Article
  4. Discovering the RNA-Binding Proteome of Plant Leaves with an Improved RNA Interactome Capture Method. Bach-Pages M, et al. Biomolecules, 2020 Apr 24. PMID 32344669, Free PMC Article
  5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

General gene information

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NM_120811.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables mRNA binding HDA PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within meristem development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
MEI2-like 4
NP_196346.1
  • MEI2-like 4 (ML4); FUNCTIONS IN: RNA binding, nucleotide binding, nucleic acid binding; INVOLVED IN: meristem development; LOCATED IN: cellular_component unknown; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), RNA recognition motif 2 (InterPro:IPR007201), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: MEI2-like protein 1 (TAIR:AT5G61960.2); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    2293114..2298976
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_120811.5 → NP_196346.1  MEI2-like 4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_196346.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LYN7
    UniProtKB/TrEMBL
    A0A178UM13, A0A654FZ73
    Conserved Domains (4) summary
    pfam04059
    Location:741 → 837
    RRM_2; RNA recognition motif 2
    COG0724
    Location:655 → 898
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12276
    Location:295 → 364
    RRM2_MEI2_EAR1_like; RNA recognition motif 2 in Mei2-like proteins and terminal EAR1-like proteins
    cd12524
    Location:210 → 286
    RRM1_MEI2_like; RNA recognition motif 1 in plant Mei2-like proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LYN7.1

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