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ENTH/VHS family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 831043, updated on 18-Sep-2024

Summary

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Official Full Name
ENTH/VHS family protein
Primary source
TAIR:AT5G11710
Locus tag
AT5G11710
See related
Araport:AT5G11710
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
T22P22.100; T22P22_100
Summary
EPSIN1 plays an important role in the vacuolar trafficking of soluble proteins at the trans-Golgi network via its interaction with gamma-ADR, VTI11, VSR1, and clathrin. Associated with actin filaments and with the Golgi complex. Expressed in most tissues.
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Genomic context

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Location:
chromosome: 5
Exon count:
13
Sequence:
Chromosome: 5; NC_003076.8 (3772401..3776671)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene translocase inner membrane subunit 17-3 Neighboring gene ephrin type-B receptor Neighboring gene Glycosyl hydrolases family 31 protein Neighboring gene Core-2/I-branching beta-1,6-N-acetylglucosaminyltransferase family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. EPSIN1 Modulates the Plasma Membrane Abundance of FLAGELLIN SENSING2 for Effective Immune Responses. Collins CA, et al. Plant Physiol, 2020 Apr. PMID 32094305, Free PMC Article
  2. EPSIN1 and MTV1 define functionally overlapping but molecularly distinct trans-Golgi network subdomains in Arabidopsis. Heinze L, et al. Proc Natl Acad Sci U S A, 2020 Oct 13. PMID 32989160, Free PMC Article
  3. Arabidopsis EPSIN1 plays an important role in vacuolar trafficking of soluble cargo proteins in plant cells via interactions with clathrin, AP-1, VTI11, and VSR1. Song J, et al. Plant Cell, 2006 Sep. PMID 16905657, Free PMC Article
  4. EpsinR2 interacts with clathrin, adaptor protein-3, AtVTI12, and phosphatidylinositol-3-phosphate. Implications for EpsinR2 function in protein trafficking in plant cells. Lee GJ, et al. Plant Physiol, 2007 Apr. PMID 17277094, Free PMC Article
  5. The deubiquitinating enzyme AMSH3 is required for intracellular trafficking and vacuole biogenesis in Arabidopsis thaliana. Isono E, et al. Plant Cell, 2010 Jun. PMID 20543027, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EPSIN1 and MTV1 define functionally overlapping but molecularly distinct trans-Golgi network subdomains in Arabidopsis.
    Title: EPSIN1 and MTV1 define functionally overlapping but molecularly distinct trans-Golgi network subdomains in Arabidopsis.
  2. EPSIN1 has a role in the vacuolar trafficking of soluble proteins at the trans-Golgi network via its interaction with gamma-ADR, VTI11, VSR1, and clathrin. [EPSIN1]
    Title: Arabidopsis EPSIN1 plays an important role in vacuolar trafficking of soluble cargo proteins in plant cells via interactions with clathrin, AP-1, VTI11, and VSR1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001343211.1
NM_001343212.1
NM_121209.6

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables clathrin binding IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables phospholipid binding TAS
Traceable Author Statement
more info
 PubMed 
enables protease binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein targeting to vacuole IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in actin filament IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in thylakoid HDA PubMed 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ENTH/VHS family protein
NP_001318545.1
  • ENTH/VHS family protein; FUNCTIONS IN: binding; INVOLVED IN: protein targeting to vacuole; LOCATED IN: thylakoid, actin filament, Golgi apparatus; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Epsin, N-terminal (InterPro:IPR001026), Epsin-like, N-terminal (InterPro:IPR013809), ENTH/VHS (InterPro:IPR008942); BEST Arabidopsis thaliana protein match is: ENTH/VHS family protein (TAIR:AT2G43160.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    3772401..3776671
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001343211.1 → NP_001318545.1  ENTH/VHS family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0WLJ9, Q8VY07, Q9LYF9
    UniProtKB/TrEMBL
    A0A5S9Y3D3, A0A654G0G8
    Conserved Domains (1) summary
    cd03571
    Location:28 → 144
    ENTH; Epsin N-Terminal Homology (ENTH) domain family

  2. NM_001343212.1 → NP_001331892.1  ENTH/VHS family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0WLJ9, Q8VY07, Q9LYF9
    UniProtKB/TrEMBL
    A0A5S9Y3D3, A0A654G0G8
    Conserved Domains (1) summary
    cd03571
    Location:28 → 144
    ENTH; Epsin N-Terminal Homology (ENTH) domain family

  3. NM_121209.6 → NP_196732.2  ENTH/VHS family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_196732.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0WLJ9, Q8VY07, Q9LYF9
    UniProtKB/TrEMBL
    A0A5S9Y3D3, A0A654G0G8
    Conserved Domains (1) summary
    cd03571
    Location:28 → 144
    ENTH; Epsin N-Terminal Homology (ENTH) domain family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VY07.1

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