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5-FCL 5-formyltetrahydrofolate cycloligase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 831144, updated on 18-Sep-2024

Summary

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Official Symbol
5-FCL
Official Full Name
5-formyltetrahydrofolate cycloligase
Primary source
TAIR:AT5G13050
Locus tag
AT5G13050
See related
Araport:AT5G13050
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
5-CHO-THF CYCLOLIGASE; 5-formyltetrahydrofolate cycloligase; T19L5.10; T19L5_10
Summary
5-Formyltetrahydrofolate cycloligase (5-CHO-THF cycloligase - AT5G13050.1) regulates/influences under photorespiratory conditions the activity of another gene product, i.e. serine hydroxymethyltransferase (SHMT) due to accumulating amounts of 5-Formyltetrahydrofolate
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Genomic context

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See 5-FCL in Genome Data Viewer
Location:
chromosome: 5
Exon count:
8
Sequence:
Chromosome: 5; NC_003076.8 (4136556..4138792, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene RNA helicase family protein Neighboring gene Emsy N Terminus (ENT)/ plant Tudor-like domains-containing protein Neighboring gene selenoprotein O Neighboring gene ARMADILLO BTB protein 1 Neighboring gene MSF1-like family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. 5-Formyltetrahydrofolate is an inhibitory but well tolerated metabolite in Arabidopsis leaves. Goyer A, et al. J Biol Chem, 2005 Jul 15. PMID 15888445
  2. Cloning and characterization of mitochondrial 5-formyltetrahydrofolate cycloligase from higher plants. Roje S, et al. J Biol Chem, 2002 Nov 8. PMID 12207015
  3. Translational Regulation of Metabolic Dynamics during Effector-Triggered Immunity. Yoo H, et al. Mol Plant, 2020 Jan 6. PMID 31568832, Free PMC Article
  4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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NM_001036796.2
NM_121308.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables 5-formyltetrahydrofolate cyclo-ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 5-formyltetrahydrofolate cyclo-ligase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within defense response IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within tetrahydrofolate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
5-formyltetrahydrofolate cycloligase
NP_001031873.1
  • 5-formyltetrahydrofolate cycloligase (5-FCL); CONTAINS InterPro DOMAIN/s: 5-formyltetrahydrofolate cyclo-ligase (InterPro:IPR002698); Has 1110 Blast hits to 1110 proteins in 558 species: Archae - 4; Bacteria - 853; Metazoa - 105; Fungi - 55; Plants - 43; Viruses - 0; Other Eukaryotes - 50 (source: NCBI BLink).
NP_568284.1
  • 5-formyltetrahydrofolate cycloligase (5-FCL); CONTAINS InterPro DOMAIN/s: 5-formyltetrahydrofolate cyclo-ligase (InterPro:IPR002698); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    4136556..4138792 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_121308.2 → NP_568284.1  5-formyltetrahydrofolate cycloligase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_568284.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4K2F3, Q84WD9, Q8L539, Q9FYA5
    UniProtKB/TrEMBL
    A0A178UBC3, A0A654G0R0
    Conserved Domains (1) summary
    PLN02812
    Location:54 → 267
    PLN02812; 5-formyltetrahydrofolate cyclo-ligase

  2. NM_001036796.2 → NP_001031873.1  5-formyltetrahydrofolate cycloligase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031873.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UD81
    Conserved Domains (1) summary
    PLN02812
    Location:54 → 208
    PLN02812; 5-formyltetrahydrofolate cyclo-ligase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8L539.1

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