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PIN8 Auxin efflux carrier family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 831362, updated on 18-Sep-2024

Summary

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Official Symbol
PIN8
Official Full Name
Auxin efflux carrier family protein
Primary source
TAIR:AT5G15100
Locus tag
AT5G15100
See related
Araport:AT5G15100
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATPIN8; F2G14.220; F2G14_220; PIN-FORMED 8
Summary
Encodes an auxin transporter with a strong expression in a male gametophyte. Mutant studies reveal a role for auxin transport in regulating pollen development and function. It acts together with PIN5.
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Genomic context

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See PIN8 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
6
Sequence:
Chromosome: 5; NC_003076.8 (4892016..4894113, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Protein kinase superfamily protein Neighboring gene voltage dependent anion channel 3 Neighboring gene Pectate lyase family protein Neighboring gene 2-aminoethanethiol dioxygenase, putative (DUF1637)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structures and mechanism of the plant PIN-FORMED auxin transporter. Ung KL, et al. Nature, 2022 Sep. PMID 35768502, Free PMC Article
  2. Intracellular auxin transport in pollen: PIN8, PIN5 and PILS5. Dal Bosco C, et al. Plant Signal Behav, 2012 Nov. PMID 22990451, Free PMC Article
  3. The endoplasmic reticulum localized PIN8 is a pollen-specific auxin carrier involved in intracellular auxin homeostasis. Dal Bosco C, et al. Plant J, 2012 Sep. PMID 22540348
  4. Arabidopsis antiporter CHX23 and auxin transporter PIN8 coordinately regulate pollen growth. Gao S, et al. J Plant Physiol, 2021 Nov. PMID 34628190
  5. ER-localized auxin transporter PIN8 regulates auxin homeostasis and male gametophyte development in Arabidopsis. Ding Z, et al. Nat Commun, 2012 Jul 3. PMID 22760640

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structures and mechanism of the plant PIN-FORMED auxin transporter.
    Title: Structures and mechanism of the plant PIN-FORMED auxin transporter.
  2. Arabidopsis antiporter CHX23 and auxin transporter PIN8 coordinately regulate pollen growth.
    Title: Arabidopsis antiporter CHX23 and auxin transporter PIN8 coordinately regulate pollen growth.
  3. Data demonstrated a role for PIN8 in intracellular auxin homeostasis.
    Title: Intracellular auxin transport in pollen: PIN8, PIN5 and PILS5.
  4. endoplasmic reticulum-localized PIN8 controls auxin thresholds and access of auxin to the nucleus, thereby regulating auxin-dependent transcriptional activity
    Title: The endoplasmic reticulum localized PIN8 is a pollen-specific auxin carrier involved in intracellular auxin homeostasis.
  5. ER-localized auxin transporter PIN8 regulates auxin homeostasis and male gametophyte development in Arabidopsis.
    Title: ER-localized auxin transporter PIN8 regulates auxin homeostasis and male gametophyte development in Arabidopsis.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables auxin efflux transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within auxin export across the plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in auxin export across the plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within pollen development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within pollen development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Auxin efflux carrier family protein
NP_197014.1
  • PIN-FORMED 8 (PIN8); FUNCTIONS IN: auxin:hydrogen symporter activity, transporter activity; INVOLVED IN: auxin polar transport, transmembrane transport; LOCATED IN: endomembrane system, integral to membrane; EXPRESSED IN: 9 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Auxin efflux carrier, subgroup (InterPro:IPR014024), Auxin efflux carrier (InterPro:IPR004776); BEST Arabidopsis thaliana protein match is: Auxin efflux carrier family protein (TAIR:AT5G16530.1); Has 2836 Blast hits to 2583 proteins in 784 species: Archae - 43; Bacteria - 1603; Metazoa - 103; Fungi - 0; Plants - 634; Viruses - 0; Other Eukaryotes - 453 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    4892016..4894113 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_121514.2 → NP_197014.1  Auxin efflux carrier family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_197014.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LFP6
    UniProtKB/TrEMBL
    A0A178UI91
    Conserved Domains (1) summary
    pfam03547
    Location:9 → 362
    Mem_trans; Membrane transport protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LFP6.1

Gene LinkOut

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