RGP2 reversibly glycosylated polypeptide 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: RGP2
Official Full Name: reversibly glycosylated polypeptide 2
Primary source: TAIR:AT5G15650
Locus tag: AT5G15650
See related: Araport:AT5G15650
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATRGP2; F14F8.30; F14F8_30; reversibly glycosylated polypeptide 2; REVERSIBLY GLYCOSYLATED POLYPEPTIDE 2
Summary: RGP2 is a UDP-arabinose mutase that catalyzes the interconversion between the pyranose and furanose forms of UDP-L-arabinose. It appears to be required for proper cell wall formation. rgp1(at3g02230)/rgp2 double mutants have a male gametophyte lethal phenotype. RGP2 fusion proteins can be found in the cytosol and peripherally associated with the Golgi apparatus. RGP2 was originally identified as Reversibly Glycosylated Polypeptide-2. Constitutive expression in tobacco impairs plant development and virus spread.
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Genomic context

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See RGP2 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 4

Sequence:: Chromosome: 5; NC_003076.8 (5092140..5095302)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RGP2 cysteine-257 to tyrosine-257 mutation results in the cell wall arabinose deficient Arabidopsis and affects protein stability.
Title: The Cell Wall Arabinose-Deficient Arabidopsis thaliana Mutant murus5 Encodes a Defective Allele of REVERSIBLY GLYCOSYLATED POLYPEPTIDE2.
RGP2 is required during microspore development and pollen mitosis, either affecting cell division and/or vacuolar integrity.
Title: Arabidopsis reversibly glycosylated polypeptides 1 and 2 are essential for pollen development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_121569.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables UDP-arabinopyranose mutase activity	IDA Inferred from Direct Assay more info	PubMed
enables intramolecular transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within UDP-L-arabinose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within arabinose biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plant-type cell wall biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plant-type cell wall organization or biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pollen development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in cytosolic ribosome	HDA more info	PubMed
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
located_in plant-type cell wall	HDA more info	PubMed
located_in plastid	HDA more info	PubMed

General protein information

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Preferred Names: reversibly glycosylated polypeptide 2

NP_197069.1

reversibly glycosylated polypeptide 2 (RGP2); FUNCTIONS IN: transferase activity, transferring hexosyl groups, glycogenin glucosyltransferase activity; INVOLVED IN: response to cadmium ion, response to salt stress; LOCATED IN: cytosolic ribosome, cell wall, membrane; EXPRESSED IN: male gametophyte, guard cell, root, cultured cell, leaf; EXPRESSED DURING: seedling growth, seed development stages; CONTAINS InterPro DOMAIN/s: Alpha-1,4-glucan-protein synthase, UDP-forming (InterPro:IPR004901); BEST Arabidopsis thaliana protein match is: reversibly glycosylated polypeptide 1 (TAIR:AT3G02230.1); Has 259 Blast hits to 255 proteins in 45 species: Archae - 24; Bacteria - 8; Metazoa - 0; Fungi - 0; Plants - 223; Viruses - 0; Other Eukaryotes - 4 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

5092140..5095302

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_121569.3 → NP_197069.1 reversibly glycosylated polypeptide 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_197069.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O22428, Q8LB19, Q9LFW1

UniProtKB/TrEMBL

A0A178UG61, A0A384L2V5, W8QN98

Conserved Domains (1) summary

PLN03180
Location:12 → 355

PLN03180; reversibly glycosylated polypeptide; Provisional