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CO B-box type zinc finger protein with CCT domain-containing protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 831441, updated on 18-Sep-2024

Summary

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Official Symbol
CO
Official Full Name
B-box type zinc finger protein with CCT domain-containing protein
Primary source
TAIR:AT5G15840
Locus tag
AT5G15840
See related
Araport:AT5G15840
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
B-box domain protein 1; BBX1; CONSTANS; F14F8.220; F14F8_220; FG
Summary
Encodes a protein showing similarities to zinc finger transcription factors, involved in regulation of flowering under long days. Acts upstream of FT and SOC1.
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Genomic context

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Location:
chromosome: 5
Exon count:
1
Sequence:
Chromosome: 5; NC_003076.8 (5170162..5173085, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene CONSTANS-like 1 Neighboring gene uncharacterized protein Neighboring gene prenylcysteine methylesterase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Variation in Arabidopsis flowering time associated with cis-regulatory variation in CONSTANS. Rosas U, et al. Nat Commun, 2014 Apr 16. PMID 24736505, Free PMC Article
  2. Crystal structure of a tandem B-box domain from Arabidopsis CONSTANS. Dahal P, et al. Biochem Biophys Res Commun, 2022 Apr 9. PMID 35168062
  3. CONSTANS mediates between the circadian clock and the control of flowering in Arabidopsis. Suárez-López P, et al. Nature, 2001 Apr 26. PMID 11323677
  4. Graft transmission of a floral stimulant derived from CONSTANS. Ayre BG, et al. Plant Physiol, 2004 Aug. PMID 15299137, Free PMC Article
  5. Circadian Clock and Photoperiodic Flowering in Arabidopsis: CONSTANS Is a Hub for Signal Integration. Shim JS, et al. Plant Physiol, 2017 Jan. PMID 27688622, Free PMC Article

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Photoperiodic flowering in Arabidopsis: Multilayered regulatory mechanisms of CONSTANS and the florigen FLOWERING LOCUS T.
    Title: Photoperiodic flowering in Arabidopsis: Multilayered regulatory mechanisms of CONSTANS and the florigen FLOWERING LOCUS T.
  2. Crystal structure of a tandem B-box domain from Arabidopsis CONSTANS.
    Title: Crystal structure of a tandem B-box domain from Arabidopsis CONSTANS.
  3. Nucleoporin 160 Regulates Flowering through Anchoring HOS1 for Destabilizing CO in Arabidopsis.
    Title: Nucleoporin 160 Regulates Flowering through Anchoring HOS1 for Destabilizing CO in Arabidopsis.
  4. Structural insights into the multivalent binding of the Arabidopsis FLOWERING LOCUS T promoter by the CO-NF-Y master transcription factor complex.
    Title: Structural insights into the multivalent binding of the Arabidopsis FLOWERING LOCUS T promoter by the CO-NF-Y master transcription factor complex.
  5. The Arabidopsis histone demethylase JMJ28 regulates CONSTANS by interacting with FBH transcription factors.
    Title: The Arabidopsis histone demethylase JMJ28 regulates CONSTANS by interacting with FBH transcription factors.
  6. CONSTANS-FKBP12 interaction contributes to modulation of photoperiodic flowering in Arabidopsis.
    Title: CONSTANS-FKBP12 interaction contributes to modulation of photoperiodic flowering in Arabidopsis.
  7. A PIF7-CONSTANS-Centered Molecular Regulatory Network Underlying Shade-Accelerated Flowering
    Title: A PIF7-CONSTANS-Centered Molecular Regulatory Network Underlying Shade-Accelerated Flowering.
  8. PKL activates FT transcription likely through facilitating access of CO to FT chromatin at dusk to synchronize flowering time in response to environmental cues.
    Title: The chromatin-remodelling factor PICKLE interacts with CONSTANS to promote flowering in Arabidopsis.
  9. These observations are consistent with the long-standing but not demonstrated model where CO can inhibit FT induction of flowering by affecting TFL1 expression.
    Title: CONSTANS delays Arabidopsis flowering under short days.
  10. GI plays a pivotal role in CO stability for the precise control of flowering by coordinating balanced functional properties of FKF1 and ZTL.
    Title: GIGANTEA Regulates the Timing Stabilization of CONSTANS by Altering the Interaction between FKF1 and ZEITLUPE.
Submit: New GeneRIF Correction See all GeneRIFs (54)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001036810.2
NM_121589.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within circadian rhythm IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within far-red light signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within flower development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of flower development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to far red light IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
  

General protein information

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Preferred Names
B-box type zinc finger protein with CCT domain-containing protein
NP_001031887.1
  • CONSTANS (CO); CONTAINS InterPro DOMAIN/s: Zinc finger, B-box (InterPro:IPR000315); BEST Arabidopsis thaliana protein match is: CONSTANS-like 2 (TAIR:AT3G02380.1); Has 2142 Blast hits to 1417 proteins in 117 species: Archae - 0; Bacteria - 0; Metazoa - 6; Fungi - 2; Plants - 2004; Viruses - 0; Other Eukaryotes - 130 (source: NCBI BLink).
NP_197088.1
  • CONSTANS (CO); CONTAINS InterPro DOMAIN/s: CCT domain (InterPro:IPR010402), Zinc finger, B-box (InterPro:IPR000315); BEST Arabidopsis thaliana protein match is: CONSTANS-like 2 (TAIR:AT3G02380.1); Has 3403 Blast hits to 2554 proteins in 146 species: Archae - 0; Bacteria - 0; Metazoa - 118; Fungi - 2; Plants - 3122; Viruses - 0; Other Eukaryotes - 161 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    5170162..5173085 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_121589.2 → NP_197088.1  B-box type zinc finger protein with CCT domain-containing protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_197088.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q2V373, Q39057
    UniProtKB/TrEMBL
    A0A178UTB8, A0A5S9Y5C0
    Conserved Domains (2) summary
    cd19821
    Location:19 → 62
    Bbox1_BBX-like; B-box-type 1 zinc finger found in B-box (BBX) family of plant transcription factors and similar proteins
    pfam06203
    Location:306 → 349
    CCT; CCT motif

  2. NM_001036810.2 → NP_001031887.1  B-box type zinc finger protein with CCT domain-containing protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031887.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q39057
    Conserved Domains (2) summary
    smart00336
    Location:58 → 105
    BBOX; B-Box-type zinc finger
    cd00021
    Location:18 → 62
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q39057.1

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