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NIK1 NSP-interacting kinase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 831457, updated on 18-Sep-2024

Summary

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Official Symbol
NIK1
Official Full Name
NSP-interacting kinase 1
Primary source
TAIR:AT5G16000
Locus tag
AT5G16000
See related
Araport:AT5G16000
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtNIK1; F1N13.140; F1N13_140; NSP-interacting kinase 1
Summary
NSP-interacting kinase (NIK1), receptor-like kinase, involved in defense response against geminivirus It acts as a virulence target of the begomovirus nuclear shuttle protein (NSP).
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Genomic context

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See NIK1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
9
Sequence:
Chromosome: 5; NC_003076.8 (5223934..5227288)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene 3-oxo-5-alpha-steroid 4-dehydrogenase family protein Neighboring gene gamete-expressed 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. NIK1, a host factor specialized in antiviral defense or a novel general regulator of plant immunity? Machado JP, et al. Bioessays, 2015 Nov. PMID 26335701
  2. Conserved threonine residues within the A-loop of the receptor NIK differentially regulate the kinase function required for antiviral signaling. Santos AA, et al. PLoS One, 2009 Jun 3. PMID 19492062, Free PMC Article
  3. The receptor-like kinase NIK1 targets FLS2/BAK1 immune complex and inversely modulates antiviral and antibacterial immunity. Li B, et al. Nat Commun, 2019 Nov 1. PMID 31676803, Free PMC Article
  4. NIK1-mediated translation suppression functions as a plant antiviral immunity mechanism. Zorzatto C, et al. Nature, 2015 Apr 30. PMID 25707794, Free PMC Article
  5. Regulated nuclear trafficking of rpL10A mediated by NIK1 represents a defense strategy of plant cells against virus. Carvalho CM, et al. PLoS Pathog, 2008 Dec. PMID 19112492, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NSP-interacting kinase 1 (NIK1) negatively regulates the formation of FLAGELLIN-SENSITIVE 2 protein (FLS2) / SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE 3 (BAK1) complex.
    Title: The receptor-like kinase NIK1 targets FLS2/BAK1 immune complex and inversely modulates antiviral and antibacterial immunity.
  2. NIK1 activation mediates the translocation of RPL10 to the nucleus, where it interacts with LIMYB to fully down-regulate translational machinery genes, resulting in translation inhibition of host and viral mRNAs and enhanced tolerance to begomovirus.
    Title: NIK1, a host factor specialized in antiviral defense or a novel general regulator of plant immunity?
  3. the constitutive activation of NIK1, a virulence target of the begomovirus nuclear shuttle protein (NSP), leads to global translation suppression and translocation of the downstream component RPL10 to the nucleus
    Title: NIK1-mediated translation suppression functions as a plant antiviral immunity mechanism.
  4. Geminivirus infection directly interferes with NIK1-mediated nuclear relocalization of rpL10A as a counterdefensive measure.
    Title: Regulated nuclear trafficking of rpL10A mediated by NIK1 represents a defense strategy of plant cells against virus.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_121605.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within defense response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
NSP-interacting kinase 1
NP_197104.1
  • NSP-interacting kinase 1 (NIK1); FUNCTIONS IN: kinase activity; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: NSP-interacting kinase 2 (TAIR:AT3G25560.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    5223934..5227288
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_121605.3 → NP_197104.1  NSP-interacting kinase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_197104.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8LA44, Q9LFS4
    UniProtKB/TrEMBL
    A0A178UEW6, A0A5S9Y580
    Conserved Domains (5) summary
    smart00219
    Location:318 → 583
    TyrKc; Tyrosine kinase, catalytic domain
    sd00033
    Location:107 → 130
    LRR_RI; leucine-rich repeat [structural motif]
    pfam08263
    Location:39 → 78
    LRRNT_2; Leucine rich repeat N-terminal domain
    pfam13855
    Location:129 → 189
    LRR_8; Leucine rich repeat
    cl21453
    Location:318 → 586
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LFS4.1

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