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FZD7 frizzled class receptor 7 [ Homo sapiens (human) ]

Gene ID: 8324, updated on 2-Nov-2024

Summary

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Official Symbol
FZD7provided by HGNC
Official Full Name
frizzled class receptor 7provided by HGNC
Primary source
HGNC:HGNC:4045
See related
Ensembl:ENSG00000155760 MIM:603410; AllianceGenome:HGNC:4045
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FzE3
Summary
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

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See FZD7 in Genome Data Viewer
Location:
2q33.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (202033855..202038441)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (202514735..202519312)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (202898578..202903164)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene UBE2V1 pseudogene 11 Neighboring gene cyclin dependent kinase 15 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:202766463-202767186 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12237 Neighboring gene RNA, U6 small nuclear 440, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:202813665-202814208 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:202814209-202814750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:202827374-202827874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:202827875-202828375 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16995 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:202835024-202835222 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:202838433-202839337 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:202860883-202861447 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:202863716-202864219 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:202864220-202864722 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:202885061-202885586 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:202887293-202888158 Neighboring gene Sharpr-MPRA regulatory region 624 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12238 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12239 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:202899462-202900302 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:202903328-202904527 Neighboring gene uncharacterized LOC124906114 Neighboring gene small nucleolar RNA U13 Neighboring gene KIAA2012

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural basis of frizzled 7 activation and allosteric regulation. Bous J, et al. Nat Commun, 2024 Aug 28. PMID 39198452, Free PMC Article
  2. Knockdown of frizzled-7 inhibits cell growth and metastasis and promotes chemosensitivity of esophageal squamous cell carcinoma cells by inhibiting Wnt signaling. Liu X, et al. Biochem Biophys Res Commun, 2017 Aug 26. PMID 28669726
  3. FZD7 is a novel prognostic marker and promotes tumor metastasis via WNT and EMT signaling pathways in esophageal squamous cell carcinoma. Cao TT, et al. Oncotarget, 2017 Sep 12. PMID 29029485, Free PMC Article
  4. Notch-Induced Expression of FZD7 Requires Noncanonical NOTCH3 Signaling in Human Breast Epithelial Cells. Bhat V, et al. Stem Cells Dev, 2016 Apr 1. PMID 26847503
  5. Frizzled7 Promotes Epithelial-to-mesenchymal Transition and Stemness Via Activating Canonical Wnt/β-catenin Pathway in Gastric Cancer. Li G, et al. Int J Biol Sci, 2018. PMID 29559846, Free PMC Article

See all (106) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HAS2 facilitates glioma cell malignancy and suppresses ferroptosis in an FZD7-dependent manner.
    Title: HAS2 facilitates glioma cell malignancy and suppresses ferroptosis in an FZD7-dependent manner.
  2. Structural basis of frizzled 7 activation and allosteric regulation.
    Title: Structural basis of frizzled 7 activation and allosteric regulation.
  3. Mechanism of miR-548b-5p down-regulating FZD7 to impede the migratory and invasive behavior of gastric carcinoma cells.
    Title: Mechanism of miR-548b-5p down-regulating FZD7 to impede the migratory and invasive behavior of gastric carcinoma cells.
  4. WNT7A promotes tumorigenesis of head and neck squamous cell carcinoma via activating FZD7/JAK1/STAT3 signaling.
    Title: WNT7A promotes tumorigenesis of head and neck squamous cell carcinoma via activating FZD7/JAK1/STAT3 signaling.
  5. FZD7: A potential biomarker for endometriosis.
    Title: FZD7: A potential biomarker for endometriosis.
  6. MiR-1-3p enhances the sensitivity of ovarian cancer cells to ferroptosis by targeting FZD7.
    Title: MiR-1-3p enhances the sensitivity of ovarian cancer cells to ferroptosis by targeting FZD7.
  7. An investigation of bacteriocin nisin anti-cancer effects and FZD7 protein interactions in liver cancer cells.
    Title: An investigation of bacteriocin nisin anti-cancer effects and FZD7 protein interactions in liver cancer cells.
  8. FZD7 accelerates hepatic metastases in pancreatic cancer by strengthening EMT and stemness associated with TGF-beta/SMAD3 signaling.
    Title: FZD7 accelerates hepatic metastases in pancreatic cancer by strengthening EMT and stemness associated with TGF-β/SMAD3 signaling.
  9. Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters.
    Title: Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters.
  10. GIPC2 interacts with Fzd7 to promote prostate cancer metastasis by activating WNT signaling.
    Title: GIPC2 interacts with Fzd7 to promote prostate cancer metastasis by activating WNT signaling.
Submit: New GeneRIF Correction See all GeneRIFs (65)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables PDZ domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables Wnt receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Wnt receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables Wnt receptor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Wnt-protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables Wnt-protein binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables frizzled binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in T cell differentiation in thymus IEA
Inferred from Electronic Annotation
more info
  
involved_in Wnt signaling pathway, planar cell polarity pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to retinoic acid ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mesenchymal to epithelial transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cardiac muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of ectodermal cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in non-canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in non-canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of JNK cascade IC
Inferred by Curator
more info
 PubMed 
involved_in positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of epithelial cell proliferation involved in wound healing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IEA
Inferred from Electronic Annotation
more info
  
involved_in somatic stem cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in substrate adhesion-dependent cell spreading IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in recycling endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
frizzled-7
Names
Frizzled, drosophila, homolog of, 7
frizzled 7, seven transmembrane spanning receptor
frizzled family receptor 7
frizzled homolog 7
fz-7
hFz7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003507.2 → NP_003498.1  frizzled-7 precursor

    See identical proteins and their annotated locations for NP_003498.1

    Status: REVIEWED

    Source sequence(s)
    AB017365, AC069148
    Consensus CDS
    CCDS2351.1
    UniProtKB/Swiss-Prot
    O75084, O94816, Q53S59, Q96B74
    Related
    ENSP00000286201.1, ENST00000286201.3
    Conserved Domains (2) summary
    cd07466
    Location:45 → 169
    CRD_FZ7; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 7 (Fz7) receptor
    cd15246
    Location:243 → 573
    7tmF_FZD7; class F frizzled subfamily 7, member of 7-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    202033855..202038441
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    202514735..202519312
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75084.2 GenPept UniProtKB/Swiss-Prot:O75084

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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