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ChaC-like family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 832691, updated on 18-Sep-2024

Summary

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Official Full Name
ChaC-like family protein
Primary source
TAIR:AT5G26220
Locus tag
AT5G26220
See related
Araport:AT5G26220
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtGGCT2;1; gamma-glutamyl cyclotransferase 2;1; GGCT2;1; T19G15.70; T19G15_70
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Genomic context

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Location:
chromosome: 5
Exon count:
7
Sequence:
Chromosome: 5; NC_003076.8 (9162969..9164884, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Cysteine/Histidine-rich C1 domain family protein Neighboring gene Mitochondrial substrate carrier family protein Neighboring gene alfin-like 4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene membrane-associated kinase regulator

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptome profiling reveals similarities and differences in plant responses to cadmium and lead. Kovalchuk I, et al. Mutat Res, 2005 Mar 1. PMID 15708574
  2. Arabidopsis γ-glutamylcyclotransferase affects glutathione content and root system architecture during sulfur starvation. Joshi NC, et al. New Phytol, 2019 Feb. PMID 30368820
  3. A γ-glutamyl cyclotransferase protects Arabidopsis plants from heavy metal toxicity by recycling glutamate to maintain glutathione homeostasis. Paulose B, et al. Plant Cell, 2013 Nov. PMID 24214398, Free PMC Article
  4. Defining the cytosolic pathway of glutathione degradation in Arabidopsis thaliana: role of the ChaC/GCG family of γ-glutamyl cyclotransferases as glutathione-degrading enzymes and AtLAP1 as the Cys-Gly peptidase. Kumar S, et al. Biochem J, 2015 May 15. PMID 25716890
  5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results point to a role for GGCT2;1 in Sulfur-starvation-response changes to root system architecture through activity of the gamma-glutamyl cycle in the primary root tip. [GGCT2;1]
    Title: Arabidopsis γ-glutamylcyclotransferase affects glutathione content and root system architecture during sulfur starvation.
  2. At5g26220 plays a role in detoxification of heavy metals and metalloids by recycling glutamate to maintain glutathione homeostasis.
    Title: A γ-glutamyl cyclotransferase protects Arabidopsis plants from heavy metal toxicity by recycling glutamate to maintain glutathione homeostasis.
Submit: New GeneRIF Correction

General gene information

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Homology

NM_001343968.1
NM_122523.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables gamma-glutamylcyclotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables gamma-glutamylcyclotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutathione specific gamma-glutamylcyclotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutathione specific gamma-glutamylcyclotransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in glutathione catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within glutathione catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to cadmium ion IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to lead ion IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ChaC-like family protein
NP_197994.1
  • ChaC-like family protein; CONTAINS InterPro DOMAIN/s: ChaC-like protein (InterPro:IPR006840); BEST Arabidopsis thaliana protein match is: ChaC-like family protein (TAIR:AT4G31290.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    9162969..9164884 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_122523.4 → NP_197994.1  ChaC-like family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_197994.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8GY54
    UniProtKB/TrEMBL
    A0A5S9Y7V9, A0A654G524, O81489
    Conserved Domains (1) summary
    cl22886
    Location:3 → 181
    GGCT_like; GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is ...

  2. NM_001343968.1 → NP_001332737.1  ChaC-like family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1R7T3I6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8GY54.1

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