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DEG14 Trypsin family protein with PDZ domain-containing protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 832828, updated on 18-Sep-2024

Summary

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Official Symbol
DEG14
Official Full Name
Trypsin family protein with PDZ domain-containing protein
Primary source
TAIR:AT5G27660
Locus tag
AT5G27660
See related
Araport:AT5G27660
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
Arabidopsis PARK13 homolog; AtPARK13; degradation of periplasmic proteins 14; PARK13; T1G16.1
Summary
Encodes a protein with similarity to human PARK13, a mitochondrial protease implicated in Parkinson disease. DEG14 is induced by heat stress and involved in degradation of misfolded proteins.
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Genomic context

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See DEG14 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
11
Sequence:
Chromosome: 5; NC_003076.8 (9789468..9792378, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene acyl-CoA binding protein 5 Neighboring gene translation initiation factor 3B1 Neighboring gene Tudor/PWWP/MBT superfamily protein Neighboring gene ncRNA Neighboring gene histone H2A 7 Neighboring gene RECQ helicase SIM

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that AtPARK13 (At5g27660) is a mitochondrial protease.
    Title: Arabidopsis AtPARK13, which confers thermotolerance, targets misfolded proteins.
Submit: New GeneRIF Correction

General gene information

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Homology

NM_001344025.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to heat IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within cellular response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within proteolysis involved in protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Trypsin family protein with PDZ domain-containing protein
NP_001318664.1
  • Trypsin family protein with PDZ domain; FUNCTIONS IN: serine-type peptidase activity, catalytic activity, serine-type endopeptidase activity; INVOLVED IN: proteolysis; EXPRESSED IN: 12 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Serine/cysteine peptidase, trypsin-like (InterPro:IPR009003), Peptidase S1C, HrtA/DegP2/Q/S (InterPro:IPR001940), Peptidase S1/S6, chymotrypsin/Hap (InterPro:IPR001254), PDZ/DHR/GLGF (InterPro:IPR001478); BEST Arabidopsis thaliana protein match is: DegP protease 1 (TAIR:AT3G27925.1); Has 16463 Blast hits to 16423 proteins in 2614 species: Archae - 115; Bacteria - 10782; Metazoa - 377; Fungi - 151; Plants - 529; Viruses - 0; Other Eukaryotes - 4509 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    9789468..9792378 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001344026.1 → NP_001330700.1  Trypsin family protein with PDZ domain-containing protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4K4D7, Q3E6S8
    UniProtKB/TrEMBL
    A0A178UPC0, A0A1P8BBM9, A0A384KP42
    Conserved Domains (1) summary
    TIGR02037
    Location:117 → 432
    degP_htrA_DO; periplasmic serine protease, Do/DeqQ family

  2. NM_001344025.1 → NP_001318664.1  Trypsin family protein with PDZ domain-containing protein, partial [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4K4D7, Q3E6S8
Nucleotide Protein
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