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LSP1 Eukaryotic initiation factor 4E protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 833534, updated on 18-Sep-2024

Summary

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Official Symbol
LSP1
Official Full Name
Eukaryotic initiation factor 4E protein
Primary source
TAIR:AT5G35620
Locus tag
AT5G35620
See related
Araport:AT5G35620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
EIF(ISO)4E; EIF4E2; eIFiso4E; EUKARYOTIC INITIATION FACTOR (ISO)4E; EUKARYOTIC INITIATION FACTOR (ISO)4E; EUKARYOTIC TRANSLATION INITATION FACTOR 4E2; eukaryotic translation Initiation Factor isoform 4E; LOSS OF SUSCEPTIBILITY TO POTYVIRUS 1; LSP; MJE4.8; MJE4_8
Summary
Cap-binding protein, binds to the 5' cap structure of nuclear-encoded mRNAs. Mutant is resistant to potyvirus infection.
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Genomic context

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See LSP1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
6
Sequence:
Chromosome: 5; NC_003076.8 (13824424..13826444, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Paired amphipathic helix (PAH2) superfamily protein Neighboring gene miscRNA Neighboring gene glutamine synthetase 2 Neighboring gene Putative endonuclease or glycosyl hydrolase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Turnip mosaic virus VPg interacts with Arabidopsis thaliana eIF(iso)4E and inhibits in vitro translation. Miyoshi H, et al. Biochimie, 2008 Oct. PMID 18582528
  2. Loss-of-susceptibility mutants of Arabidopsis thaliana reveal an essential role for eIF(iso)4E during potyvirus infection. Lellis AD, et al. Curr Biol, 2002 Jun 25. PMID 12123581
  3. Selective involvement of members of the eukaryotic initiation factor 4E family in the infection of Arabidopsis thaliana by potyviruses. Sato M, et al. FEBS Lett, 2005 Feb 14. PMID 15710407
  4. Interaction of the viral protein genome linked of turnip mosaic potyvirus with the translational eukaryotic initiation factor (iso) 4E of Arabidopsis thaliana using the yeast two-hybrid system. Wittmann S, et al. Virology, 1997 Jul 21. PMID 9234949
  5. eIFiso4G Augments the Synthesis of Specific Plant Proteins Involved in Normal Chloroplast Function. Lellis AD, et al. Plant Physiol, 2019 Sep. PMID 31308150, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. eIFiso4G Augments the Synthesis of Specific Plant Proteins Involved in Normal Chloroplast Function.
    Title: eIFiso4G Augments the Synthesis of Specific Plant Proteins Involved in Normal Chloroplast Function.
  2. Turnip mosaic virus protein linked to the genome (VPg) inhibits cap-dependent translational initiation via binding to eIF(iso)4E. [eIF(iso)4E]
    Title: Turnip mosaic virus VPg interacts with Arabidopsis thaliana eIF(iso)4E and inhibits in vitro translation.
  3. Turnip mosaic virus (TuMV), another member of the genus Potyvirus, multiplied in mutant plants lacking eIF4E but not in mutant
    Title: Selective involvement of members of the eukaryotic initiation factor 4E family in the infection of Arabidopsis thaliana by potyviruses.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_122953.3
NM_203123.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables RNA 7-methylguanosine cap binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables translation initiation factor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of defense response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within translational initiation TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus HDA PubMed 
located_in plastid HDA PubMed 

General protein information

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Preferred Names
Eukaryotic initiation factor 4E protein
NP_198412.1
  • LOSS OF SUSCEPTIBILITY TO POTYVIRUS 1 (LSP1); FUNCTIONS IN: RNA binding, RNA 7-methylguanosine cap binding, translation initiation factor activity; INVOLVED IN: translational initiation, response to virus; LOCATED IN: nucleus, cytoplasm; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Eukaryotic translation initiation factor 4E (eIF-4E) (InterPro:IPR001040), Eukaryotic translation initiation factor 4E (eIF-4E), conserved site (InterPro:IPR019770); BEST Arabidopsis thaliana protein match is: eukaryotic translation initiation factor 4E (TAIR:AT4G18040.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
NP_974852.1
  • LOSS OF SUSCEPTIBILITY TO POTYVIRUS 1 (LSP1); FUNCTIONS IN: RNA binding, RNA 7-methylguanosine cap binding, translation initiation factor activity; INVOLVED IN: translational initiation, response to virus; LOCATED IN: nucleus, cytoplasm; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Eukaryotic translation initiation factor 4E (eIF-4E) (InterPro:IPR001040), Eukaryotic translation initiation factor 4E (eIF-4E), conserved site (InterPro:IPR019770); BEST Arabidopsis thaliana protein match is: eukaryotic translation initiation factor 4E (TAIR:AT4G18040.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    13824424..13826444 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001344112.1 → NP_001332369.1  Eukaryotic initiation factor 4E protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O04663, Q3E8N6, Q546X5, Q9SAN8
    UniProtKB/TrEMBL
    A0A178UEE3, A0A5S9Y8A9
    Conserved Domains (1) summary
    pfam01652
    Location:27 → 185
    IF4E; Eukaryotic initiation factor 4E

  2. NM_122953.3 → NP_198412.1  Eukaryotic initiation factor 4E protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_198412.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O04663, Q3E8N6, Q546X5, Q9SAN8
    UniProtKB/TrEMBL
    A0A178UEE3, A0A5S9Y8A9
    Conserved Domains (1) summary
    pfam01652
    Location:27 → 185
    IF4E; Eukaryotic initiation factor 4E

  3. NM_203123.1 → NP_974852.1  Eukaryotic initiation factor 4E protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_974852.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O04663
    Conserved Domains (1) summary
    pfam01652
    Location:31 → 166
    IF4E; Eukaryotic initiation factor 4E
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O04663.2

Gene LinkOut

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