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GS2 glutamine synthetase 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 833535, updated on 18-Sep-2024

Summary

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Official Symbol
GS2
Official Full Name
glutamine synthetase 2
Primary source
TAIR:AT5G35630
Locus tag
AT5G35630
See related
Araport:AT5G35630
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATGSL1; GLN2; glutamine synthetase 2; GLUTAMINE SYNTHETASE 2; GLUTAMINE SYNTHETASE LIKE 1; MJE4.9; MJE4_9
Summary
chloroplastic glutamine synthetase
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Genomic context

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See GS2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
13
Sequence:
Chromosome: 5; NC_003076.8 (13830429..13833542)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene Eukaryotic initiation factor 4E protein Neighboring gene Putative endonuclease or glycosyl hydrolase Neighboring gene miscRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Excessive ammonium assimilation by plastidic glutamine synthetase causes ammonium toxicity in Arabidopsis thaliana. Hachiya T, et al. Nat Commun, 2021 Aug 16. PMID 34400629, Free PMC Article
  2. Validating the role of glutamine synthetase GLN2 during photorespiration in Arabidopsis thaliana. Kobercová E, et al. Plant Physiol, 2023 Dec 30. PMID 37787606, Free PMC Article
  3. Arabidopsis thaliana GLN2-encoded glutamine synthetase is dual targeted to leaf mitochondria and chloroplasts. Taira M, et al. Plant Cell, 2004 Aug. PMID 15273293, Free PMC Article
  4. Expression pattern of genes encoding nitrate and ammonium assimilating enzymes in Arabidopsis thaliana exposed to short term NaCl stress. Debouba M, et al. J Plant Physiol, 2013 Jan 15. PMID 23122335
  5. The glutamine synthetase gene family of Arabidopsis thaliana: light-regulation and differential expression in leaves, roots and seeds. Peterman TK, et al. Mol Gen Genet, 1991 Nov. PMID 1684022

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Validating the role of glutamine synthetase GLN2 during photorespiration in Arabidopsis thaliana.
    Title: Validating the role of glutamine synthetase GLN2 during photorespiration in Arabidopsis thaliana.
  2. Excessive ammonium assimilation by plastidic glutamine synthetase causes ammonium toxicity in Arabidopsis thaliana.
    Title: Excessive ammonium assimilation by plastidic glutamine synthetase causes ammonium toxicity in Arabidopsis thaliana.
  3. ACR11 is an activator of GS2.
    Title: ACR11 is an Activator of Plastid-Type Glutamine Synthetase GS2 in Arabidopsis thaliana.
  4. Drop in mRNA levels for GLN2 and GLN1 by salt was associated with a similar inhibition of glutamine synthetase activity in leaves of Arabidopsis thaliana. In roots, NaCl stress was found to enhance mRNA levels of GLN2 and cytosolic-encoding genes.
    Title: Expression pattern of genes encoding nitrate and ammonium assimilating enzymes in Arabidopsis thaliana exposed to short term NaCl stress.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

NM_001036892.1
NM_001085170.1
NM_122954.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables glutamine synthetase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutamine synthetase activity TAS
Traceable Author Statement
more info
 PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables salicylic acid binding HDA PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within ammonia assimilation cycle TAS
Traceable Author Statement
more info
 PubMed 
involved_in glutamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to cadmium ion IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in apoplast HDA PubMed 
located_in chloroplast HDA PubMed 
located_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast envelope HDA PubMed 
located_in chloroplast stroma HDA PubMed 
located_in chloroplast thylakoid membrane HDA PubMed 
located_in cytosolic ribosome HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plastid HDA PubMed 
located_in thylakoid HDA PubMed 

General protein information

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Preferred Names
glutamine synthetase 2
NP_001031969.1
  • glutamine synthetase 2 (GS2); FUNCTIONS IN: glutamate-ammonia ligase activity; INVOLVED IN: in 8 processes; LOCATED IN: in 7 components; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Glutamine synthetase, catalytic domain (InterPro:IPR008146), Glutamine synthetase, beta-Grasp (InterPro:IPR008147), Glutamine synthetase/guanido kinase, catalytic domain (InterPro:IPR014746); BEST Arabidopsis thaliana protein match is: glutamine synthase clone F11 (TAIR:AT1G66200.1); Has 8236 Blast hits to 8234 proteins in 2572 species: Archae - 144; Bacteria - 3324; Metazoa - 415; Fungi - 259; Plants - 1746; Viruses - 3; Other Eukaryotes - 2345 (source: NCBI BLink).
NP_001078639.1
  • glutamine synthetase 2 (GS2); FUNCTIONS IN: glutamate-ammonia ligase activity; INVOLVED IN: in 8 processes; LOCATED IN: in 6 components; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Glutamine synthetase, catalytic domain (InterPro:IPR008146), Glutamine synthetase, beta-Grasp (InterPro:IPR008147), Glutamine synthetase/guanido kinase, catalytic domain (InterPro:IPR014746); BEST Arabidopsis thaliana protein match is: glutamine synthase clone F11 (TAIR:AT1G66200.1); Has 8236 Blast hits to 8234 proteins in 2572 species: Archae - 144; Bacteria - 3324; Metazoa - 415; Fungi - 259; Plants - 1746; Viruses - 3; Other Eukaryotes - 2345 (source: NCBI BLink).
NP_198413.1
  • glutamine synthetase 2 (GS2); FUNCTIONS IN: glutamate-ammonia ligase activity; INVOLVED IN: in 8 processes; LOCATED IN: in 9 components; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Glutamine synthetase, catalytic domain (InterPro:IPR008146), Glutamine synthetase, beta-Grasp (InterPro:IPR008147), Glutamine synthetase/guanido kinase, catalytic domain (InterPro:IPR014746); BEST Arabidopsis thaliana protein match is: glutamine synthase clone F11 (TAIR:AT1G66200.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    13830429..13833542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_122954.4 → NP_198413.1  glutamine synthetase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_198413.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q43127
    UniProtKB/TrEMBL
    A0A178UUP0, A0A384L697, B9DGD1
    Conserved Domains (1) summary
    PLN03036
    Location:1 → 430
    PLN03036; glutamine synthetase; Provisional

  2. NM_001085170.1 → NP_001078639.1  glutamine synthetase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001078639.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q43127
    UniProtKB/TrEMBL
    A0A178UUP0, A0A384L697, B9DGD1
    Conserved Domains (1) summary
    PLN03036
    Location:1 → 430
    PLN03036; glutamine synthetase; Provisional

  3. NM_001036892.1 → NP_001031969.1  glutamine synthetase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031969.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q43127
    UniProtKB/TrEMBL
    A0A178UUP0, A0A384L697, B9DGD1
    Conserved Domains (1) summary
    PLN03036
    Location:1 → 430
    PLN03036; glutamine synthetase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q43127.1

Gene LinkOut

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