SEF HIT-type Zinc finger family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: SEF
Official Full Name: HIT-type Zinc finger family protein
Primary source: TAIR:AT5G37055
Locus tag: AT5G37055
See related: Araport:AT5G37055
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATSWC6; SERRATED LEAVES AND EARLY FLOWERING
Summary: Encodes SERRATED LEAVES AND EARLY FLOWERING (SEF), an Arabidopsis homolog of the yeast SWC6 protein, a conserved subunit of the SWR1/SRCAP complex. SEF loss-of-function mutants have a pleiotropic phenotype characterized by serrated leaves, frequent absence of inflorescence internodes, bushy aspect, and flowers with altered number and size of organs. sef plants flower earlier than wild-type plants both under inductive and non-inductive photoperiods. SEF, ARP6 and PIE1 might form a molecular complex in Arabidopsis related to the SWR1/SRCAP complex identified in other eukaryotes.
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Genomic context

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See SEF in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 4

Sequence:: Chromosome: 5; NC_003076.8 (14641442..14642513, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arabidopsis cryptochrome 1 controls photomorphogenesis through regulation of H2A.Z deposition.
Title: Arabidopsis cryptochrome 1 controls photomorphogenesis through regulation of H2A.Z deposition.
SKIP is required for the splicing of serrated leaves and early flowering (SEF) pre-messenger RNA (mRNA), which encodes a component of the ATP-dependent SWR1 chromatin remodeling complex (SWR1-C).
Title: SKIP controls flowering time via the alternative splicing of SEF pre-mRNA in Arabidopsis.
Data indicate that mutations in genes for SWR1 complex subunits photoperiod-independent Early Flowering1 (PIE1), actin-related protein6 (ARP6), and SWR1 complex6 (SWC6) cause hypersensitivity to various DNA damaging agents.
Title: The Arabidopsis SWR1 chromatin-remodeling complex is important for DNA repair, somatic recombination, and meiosis.
part of an Arabidopsis SWR1 chromatin remodelling complex involved in the regulation of diverse aspects of plant development, including floral repression through the activation of FLC and FLC-like genes
Title: Mutations in the Arabidopsis SWC6 gene, encoding a component of the SWR1 chromatin remodelling complex, accelerate flowering time and alter leaf and flower development.
Arabidopsis SWC6 (AtSWC6), SUPPRESSOR OF FRIGIDA 3 (SUF3) and PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1 (PIE1) are homologs of SWC6, ARP6 and SWR1 with roles in development, including floral repression through activation of FLOWERING LOCUS C [SWC6]
Title: Arabidopsis homologs of components of the SWR1 complex regulate flowering and plant development.
SERRATED LEAVES AND EARLY FLOWERING (SEF) gene represses flowering at least in part by positively regulating the expression of the FLC and MAF4 genes in A. thaliana. It interacts with ATARP6 and PIE1 to form a molecular complex. [SEF]
Title: SEF, a new protein required for flowering repression in Arabidopsis, interacts with PIE1 and ARP6.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_123064.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response to bacterium	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of developmental growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of flower development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Swr1 complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: HIT-type Zinc finger family protein

NP_568545.1

SERRATED LEAVES AND EARLY FLOWERING (SEF); CONTAINS InterPro DOMAIN/s: Zinc finger, HIT-type (InterPro:IPR007529); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

14641442..14642513 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_123064.3 → NP_568545.1 HIT-type Zinc finger family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_568545.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9FHW2

UniProtKB/TrEMBL

A0A178UBL6

Conserved Domains (1) summary

pfam04438
Location:130 → 159

zf-HIT; HIT zinc finger