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Pias2 protein inhibitor of activated STAT, 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 83422, updated on 9-Jul-2024

Summary

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Official Symbol
Pias2provided by RGD
Official Full Name
protein inhibitor of activated STAT, 2provided by RGD
Primary source
RGD:71056
See related
Ensembl:ENSRNOG00000017493 AllianceGenome:RGD:71056
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
DIP; Miz1; ARIP3; PiasX
Summary
Enables nuclear receptor binding activity and protein domain specific binding activity. Involved in several processes, including androgen receptor signaling pathway; positive regulation of dendrite morphogenesis; and response to testosterone. Acts upstream of or within regulation of androgen receptor signaling pathway. Located in nucleus. Orthologous to human PIAS2 (protein inhibitor of activated STAT 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 242.6), Adrenal (RPKM 191.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pias2 in Genome Data Viewer
Location:
18q12.3
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (72883008..72989486)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (70608034..70714295)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (73479863..73524956)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098312 Neighboring gene uncharacterized LOC134483057 Neighboring gene immediate early response 3 interacting protein 1 Neighboring gene haloacid dehalogenase-like hydrolase domain containing 2 Neighboring gene katanin catalytic subunit A1 like 2 Neighboring gene uncharacterized LOC102552068 Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 Neighboring gene uncharacterized LOC102551787 Neighboring gene lipoxygenase homology PLAT domains 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Decreased MIZ1 Expression in Severe Experimental Acute Pancreatitis: A Rat Study. Chen P, et al. Dig Dis Sci, 2016 Mar. PMID 26581215
  2. ZBTB17 (MIZ1) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart Failure. Buyandelger B, et al. Circ Cardiovasc Genet, 2015 Oct. PMID 26175529
  3. Androgen receptor-interacting protein 3 and other PIAS proteins cooperate with glucocorticoid receptor-interacting protein 1 in steroid receptor-dependent signaling. Kotaja N, et al. J Biol Chem, 2002 May 17. PMID 11893729
  4. Regulation of Serotonin 1A Receptor SUMOylation by SENP2 and PIASxα. Gupta S, et al. Int J Mol Sci, 2021 Dec 7. PMID 34947973, Free PMC Article
  5. PIASx is a MEF2 SUMO E3 ligase that promotes postsynaptic dendritic morphogenesis. Shalizi A, et al. J Neurosci, 2007 Sep 12. PMID 17855618, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulation of Serotonin 1A Receptor SUMOylation by SENP2 and PIASxalpha.
    Title: Regulation of Serotonin 1A Receptor SUMOylation by SENP2 and PIASxα.
  2. functions for ZBTB17 in the heart, a transcription factor that may play a role as a novel cardiomyopathy gene
    Title: ZBTB17 (MIZ1) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart Failure.
  3. Decreasing MIZ1 expression was closely correlated with inflammatory response, and development of acute necrotizing pancreatitis.
    Title: Decreased MIZ1 Expression in Severe Experimental Acute Pancreatitis: A Rat Study.
  4. Miz-1 is essential for Myc-mediated apoptosis
    Title: Targeting of Miz-1 is essential for Myc-mediated apoptosis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II-specific DNA-binding transcription factor binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables SUMO ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SUMO ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables SUMO ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables SUMO transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables nuclear androgen receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nuclear estrogen receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nuclear glucocorticoid receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in androgen receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of androgen receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of androgen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein sumoylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein sumoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein sumoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein sumoylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of androgen receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of macromolecule metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in response to testosterone IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in spermatogenesis IEP
Inferred from Expression Pattern
more info
 PubMed 
NOT involved_in transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in PML body IEA
Inferred from Electronic Annotation
more info
  
located_in PML body ISO
Inferred from Sequence Orthology
more info
  
located_in PML body ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 SUMO-protein ligase PIAS2
Names
DAB2-interacting protein
E3 SUMO-protein transferase PIAS2
androgen receptor-interacting protein 3
msx-interacting-zinc finger protein
protein inhibitor of activated STAT x
NP_001380693.1
NP_445789.2
XP_038953070.2
XP_038953071.2
XP_038953072.1
XP_038953073.2
XP_038953074.2
XP_038953075.1
XP_038953077.1
XP_038953079.2
XP_038953080.2
XP_038953081.2
XP_038953082.2
XP_038953083.2
XP_063133673.1
XP_063133674.1
XP_063133675.1
XP_063133676.1
XP_063133677.1
XP_063133678.1
XP_063133679.1
XP_063133680.1
XP_063133681.1
XP_063133682.1
XP_063133683.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393764.1 → NP_001380693.1  E3 SUMO-protein ligase PIAS2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A6KMU4
    Related
    ENSRNOP00000109402.1, ENSRNOT00000145398.1
    Conserved Domains (3) summary
    smart00513
    Location:11 → 45
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:343 → 390
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:147 → 296
    PINIT; PINIT domain

  2. NM_053337.2 → NP_445789.2  E3 SUMO-protein ligase PIAS2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/Swiss-Prot
    Q6AZ28, Q9Z177
    UniProtKB/TrEMBL
    A6KMU1
    Related
    ENSRNOP00000086650.2, ENSRNOT00000110007.2
    Conserved Domains (3) summary
    smart00513
    Location:11 → 45
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:343 → 390
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:147 → 296
    PINIT; PINIT domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    72883008..72989486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097146.2 → XP_038953074.2  E3 SUMO-protein ligase PIAS2 isoform X7

    UniProtKB/TrEMBL
    A6KMU6

  2. XM_039097154.2 → XP_038953082.2  E3 SUMO-protein ligase PIAS2 isoform X11

    UniProtKB/TrEMBL
    F1LRP3

  3. XM_063277603.1 → XP_063133673.1  E3 SUMO-protein ligase PIAS2 isoform X1

    UniProtKB/TrEMBL
    A6KMU4

  4. XM_039097142.2 → XP_038953070.2  E3 SUMO-protein ligase PIAS2 isoform X2

    UniProtKB/TrEMBL
    A6KMU4

  5. XM_039097143.2 → XP_038953071.2  E3 SUMO-protein ligase PIAS2 isoform X3

    UniProtKB/TrEMBL
    A6KMU6

  6. XM_039097152.2 → XP_038953080.2  E3 SUMO-protein ligase PIAS2 isoform X11

    UniProtKB/TrEMBL
    F1LRP3

  7. XM_039097151.2 → XP_038953079.2  E3 SUMO-protein ligase PIAS2 isoform X11

    UniProtKB/TrEMBL
    F1LRP3

  8. XM_039097153.2 → XP_038953081.2  E3 SUMO-protein ligase PIAS2 isoform X11

    UniProtKB/TrEMBL
    F1LRP3

  9. XM_039097145.2 → XP_038953073.2  E3 SUMO-protein ligase PIAS2 isoform X6

    UniProtKB/TrEMBL
    A0A8I6AHS4

  10. XM_039097155.2 → XP_038953083.2  E3 SUMO-protein ligase PIAS2 isoform X12

    UniProtKB/TrEMBL
    F1LRP3

  11. XM_063277604.1 → XP_063133674.1  E3 SUMO-protein ligase PIAS2 isoform X5

    UniProtKB/TrEMBL
    A0A8I6A470, A6KMU4
    Related
    ENSRNOP00000103276.1, ENSRNOT00000129444.1

  12. XM_063277606.1 → XP_063133676.1  E3 SUMO-protein ligase PIAS2 isoform X13

    UniProtKB/TrEMBL
    A0A8I6AHS4
    Related
    ENSRNOP00000023886.6, ENSRNOT00000023886.7

  13. XM_039097144.2 → XP_038953072.1  E3 SUMO-protein ligase PIAS2 isoform X4

    UniProtKB/TrEMBL
    A6KMU4
    Conserved Domains (3) summary
    smart00513
    Location:41 → 75
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:373 → 420
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:177 → 326
    PINIT; PINIT domain

  14. XM_063277609.1 → XP_063133679.1  E3 SUMO-protein ligase PIAS2 isoform X16

    UniProtKB/TrEMBL
    A0A8I6B6K3, A0A8I6GLW8

  15. XM_039097147.2 → XP_038953075.1  E3 SUMO-protein ligase PIAS2 isoform X8

    UniProtKB/TrEMBL
    A6KMU4
    Conserved Domains (3) summary
    smart00513
    Location:11 → 45
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:343 → 390
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:147 → 296
    PINIT; PINIT domain

  16. XM_063277607.1 → XP_063133677.1  E3 SUMO-protein ligase PIAS2 isoform X14

    UniProtKB/TrEMBL
    A0A8I6B6K3

  17. XM_063277611.1 → XP_063133681.1  E3 SUMO-protein ligase PIAS2 isoform X18

    UniProtKB/TrEMBL
    F1LRP3

  18. XM_063277612.1 → XP_063133682.1  E3 SUMO-protein ligase PIAS2 isoform X19

    UniProtKB/TrEMBL
    F1LRP3

  19. XM_063277605.1 → XP_063133675.1  E3 SUMO-protein ligase PIAS2 isoform X10

    UniProtKB/TrEMBL
    A0A8I6GK87, A6KMU4
    Related
    ENSRNOP00000092581.1, ENSRNOT00000107723.2

  20. XM_063277608.1 → XP_063133678.1  E3 SUMO-protein ligase PIAS2 isoform X15

    UniProtKB/TrEMBL
    A6KMU6

  21. XM_039097149.2 → XP_038953077.1  E3 SUMO-protein ligase PIAS2 isoform X9

    UniProtKB/TrEMBL
    A6KMU2, A6KMU4
    Conserved Domains (3) summary
    smart00513
    Location:4 → 38
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    cd16790
    Location:336 → 383
    SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
    pfam14324
    Location:140 → 289
    PINIT; PINIT domain

  22. XM_063277610.1 → XP_063133680.1  E3 SUMO-protein ligase PIAS2 isoform X17

    UniProtKB/TrEMBL
    A0A8I6AHS4, A6KMU3

  23. XM_063277613.1 → XP_063133683.1  E3 SUMO-protein ligase PIAS2 isoform X20

    UniProtKB/TrEMBL
    F1LRP3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AZ28.1 GenPept UniProtKB/Swiss-Prot:Q6AZ28

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