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SPP Insulinase (Peptidase family M16) family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 834245, updated on 18-Sep-2024

Summary

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Official Symbol
SPP
Official Full Name
Insulinase (Peptidase family M16) family protein
Primary source
TAIR:AT5G42390
Locus tag
AT5G42390
See related
Araport:AT5G42390
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
MDH9.8; MDH9_8; stromal processing peptidase
Summary
Encodes a chloroplast-localized metalloprotease that is essential for embryo development. Mutants do not progress normally beyond the 16-cell stage.
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Genomic context

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See SPP in Genome Data Viewer
Location:
chromosome: 5
Exon count:
25
Sequence:
Chromosome: 5; NC_003076.8 (16945165..16953353)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Calcineurin-like metallo-phosphoesterase superfamily protein Neighboring gene calmodulin like 37 Neighboring gene SET domain protein 25 Neighboring gene SAUR-like auxin-responsive protein family

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The stromal processing peptidase of chloroplasts is essential in Arabidopsis, with knockout mutations causing embryo arrest after the 16-cell stage. Trösch R, et al. PLoS One, 2011. PMID 21857988, Free PMC Article
  2. Capturing the phosphorylation and protein interaction landscape of the plant TOR kinase. Van Leene J, et al. Nat Plants, 2019 Mar. PMID 30833711
  3. Quantitative proteomics of a chloroplast SRP54 sorting mutant and its genetic interactions with CLPC1 in Arabidopsis. Rutschow H, et al. Plant Physiol, 2008 Sep. PMID 18633119, Free PMC Article
  4. Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins. Heazlewood JL, et al. Plant Cell, 2004 Jan. PMID 14671022, Free PMC Article
  5. Discovering the RNA-Binding Proteome of Plant Leaves with an Improved RNA Interactome Capture Method. Bach-Pages M, et al. Biomolecules, 2020 Apr 24. PMID 32344669, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that one copy of the SPP gene (At5g42390) is able to produce sufficient SPP protein for normal development under standard growth conditions.
    Title: The stromal processing peptidase of chloroplasts is essential in Arabidopsis, with knockout mutations causing embryo arrest after the 16-cell stage.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001344443.1
NM_123604.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within embryo development ending in seed dormancy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast stroma HDA PubMed 
located_in mitochondrion HDA PubMed 
located_in plastid HDA PubMed 

General protein information

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Preferred Names
Insulinase (Peptidase family M16) family protein
NP_199054.1
  • Insulinase (Peptidase family M16) family protein; FUNCTIONS IN: metalloendopeptidase activity, zinc ion binding, catalytic activity, metal ion binding; INVOLVED IN: proteolysis; LOCATED IN: mitochondrion, chloroplast stroma, chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase M16, C-terminal (InterPro:IPR007863), Peptidase M16, N-terminal (InterPro:IPR011765), Metalloenzyme, LuxS/M16 peptidase-like, metal-binding (InterPro:IPR011249), Peptidase M16, core (InterPro:IPR011237); BEST Arabidopsis thaliana protein match is: Insulinase (Peptidase family M16) protein (TAIR:AT5G56730.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    16945165..16953353
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_123604.3 → NP_199054.1  Insulinase (Peptidase family M16) family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_199054.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O48870, Q9FIH8
    UniProtKB/TrEMBL
    A0A5S9YAA2, A0A654G7G2
    Conserved Domains (2) summary
    COG0612
    Location:189 → 403
    PqqL; Predicted Zn-dependent peptidase [General function prediction only]
    pfam05193
    Location:928 → 1156
    Peptidase_M16_C; Peptidase M16 inactive domain

  2. NM_001344443.1 → NP_001331624.1  Insulinase (Peptidase family M16) family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8BEG1, A0A5S9YAA2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FIH8.1

Gene LinkOut

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