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Celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 83466, updated on 2-Nov-2024

Summary

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Official Symbol
Celsr3provided by RGD
Official Full Name
cadherin, EGF LAG seven-pass G-type receptor 3provided by RGD
Primary source
RGD:621787
See related
EnsemblRapid:ENSRNOG00000053889 AllianceGenome:RGD:621787
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Megf2
Summary
Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Predicted to be involved in Wnt signaling pathway, planar cell polarity pathway; axon guidance; and cell-cell adhesion. Predicted to act upstream of or within several processes, including cilium assembly; generation of neurons; and regulation of protein phosphorylation. Predicted to be located in plasma membrane. Predicted to be active in glutamatergic synapse; postsynaptic density membrane; and presynaptic active zone membrane. Orthologous to human CELSR3 (cadherin EGF LAG seven-pass G-type receptor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 37.7), Adrenal (RPKM 10.3) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Celsr3 in Genome Data Viewer
Location:
8q32
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (118409136..118438593)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (109530597..109558360)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (117620293..117648034)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene inositol hexakisphosphate kinase 2 Neighboring gene small nucleolar RNA SNORA28 Neighboring gene NCK interacting protein with SH3 domain Neighboring gene solute carrier family 26 member 6 Neighboring gene U2 spliceosomal RNA Neighboring gene transmembrane protein 89

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Complexes of matrilin-1 and biglycan or decorin connect collagen VI microfibrils to both collagen II and aggrecan. Wiberg C, et al. J Biol Chem, 2003 Sep 26. PMID 12840020
  2. Opposing roles in neurite growth control by two seven-pass transmembrane cadherins. Shima Y, et al. Nat Neurosci, 2007 Aug. PMID 17618280
  3. The flamingo-related mouse Celsr family (Celsr1-3) genes exhibit distinct patterns of expression during embryonic development. Formstone CJ, et al. Mech Dev, 2001 Nov. PMID 11677057
  4. Protocadherin Celsr3 is crucial in axonal tract development. Tissir F, et al. Nat Neurosci, 2005 Apr. PMID 15778712
  5. Wnt/planar cell polarity signaling controls the anterior-posterior organization of monoaminergic axons in the brainstem. Fenstermaker AG, et al. J Neurosci, 2010 Nov 24. PMID 21106844, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Celsr3 suppressed neurite growth of neuron in hippocampus of rat.
    Title: Opposing roles in neurite growth control by two seven-pass transmembrane cadherins.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in Wnt signaling pathway, planar cell polarity pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within axonal fasciculation ISO
Inferred from Sequence Orthology
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in dopaminergic neuron axon guidance ISO
Inferred from Sequence Orthology
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within motor neuron migration ISO
Inferred from Sequence Orthology
more info
  
involved_in neurogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in serotonergic neuron axon guidance ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cadherin EGF LAG seven-pass G-type receptor 3
Names
cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
multiple EGF-like domains protein 2
multiple epidermal growth factor-like domains 2
multiple epidermal growth factor-like domains protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031320.1 → NP_112610.1  cadherin EGF LAG seven-pass G-type receptor 3 precursor

    See identical proteins and their annotated locations for NP_112610.1

    Status: PROVISIONAL

    Source sequence(s)
    AB011528
    UniProtKB/Swiss-Prot
    O88278
    UniProtKB/TrEMBL
    A0A8L2R1D5
    Related
    ENSRNOP00000068821.3, ENSRNOT00000084220.3
    Conserved Domains (9) summary
    smart00303
    Location:2474 → 2527
    GPS; G-protein-coupled receptor proteolytic site domain
    cd11304
    Location:646 → 743
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00008
    Location:2117 → 2181
    HormR; Domain present in hormone receptors
    cd00054
    Location:1717 → 1748
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:2067 → 2105
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:1508 → 1691
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00002
    Location:2534 → 2766
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam00053
    Location:1994 → 2033
    Laminin_EGF; Laminin EGF domain
    pfam16489
    Location:2201 → 2446
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    118409136..118438593
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243860.5 → XP_006243922.1  cadherin EGF LAG seven-pass G-type receptor 3 isoform X1

    UniProtKB/TrEMBL
    A0A8L2R1D5
    Conserved Domains (9) summary
    smart00303
    Location:2474 → 2527
    GPS; G-protein-coupled receptor proteolytic site domain
    cd11304
    Location:646 → 743
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00008
    Location:2117 → 2181
    HormR; Domain present in hormone receptors
    cd00054
    Location:1717 → 1748
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:2067 → 2105
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:1508 → 1691
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00002
    Location:2534 → 2765
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam00053
    Location:1994 → 2033
    Laminin_EGF; Laminin EGF domain
    pfam16489
    Location:2201 → 2446
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  2. XM_039082204.2 → XP_038938132.1  cadherin EGF LAG seven-pass G-type receptor 3 isoform X2

    UniProtKB/TrEMBL
    A0A8L2R1D5
    Conserved Domains (11) summary
    smart00303
    Location:2469 → 2522
    GPS; G-protein-coupled receptor proteolytic site domain
    cd11304
    Location:646 → 743
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00008
    Location:2117 → 2176
    HormR; Domain present in hormone receptors
    PHA03247
    Location:3085 → 3284
    PHA03247; large tegument protein UL36; Provisional
    cd00054
    Location:1717 → 1748
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:2067 → 2105
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:1508 → 1691
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:1994 → 2033
    Laminin_EGF; Laminin EGF domain
    pfam16489
    Location:2195 → 2443
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:2531 → 2556
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:2529 → 2782
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. XM_039082205.2 → XP_038938133.1  cadherin EGF LAG seven-pass G-type receptor 3 isoform X3

    UniProtKB/TrEMBL
    A0A8L2R1D5
    Conserved Domains (11) summary
    smart00303
    Location:2469 → 2522
    GPS; G-protein-coupled receptor proteolytic site domain
    cd11304
    Location:646 → 743
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00008
    Location:2117 → 2176
    HormR; Domain present in hormone receptors
    PHA03247
    Location:3084 → 3283
    PHA03247; large tegument protein UL36; Provisional
    cd00054
    Location:1717 → 1748
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:2067 → 2105
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:1508 → 1691
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:1994 → 2033
    Laminin_EGF; Laminin EGF domain
    pfam16489
    Location:2195 → 2443
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:2531 → 2556
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:2529 → 2781
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  4. XM_063266218.1 → XP_063122288.1  cadherin EGF LAG seven-pass G-type receptor 3 isoform X4

  5. XM_006243861.5 → XP_006243923.1  cadherin EGF LAG seven-pass G-type receptor 3 isoform X5

    UniProtKB/TrEMBL
    A6I391
    Conserved Domains (10) summary
    smart00303
    Location:2474 → 2527
    GPS; G-protein-coupled receptor proteolytic site domain
    cd11304
    Location:646 → 743
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00008
    Location:2117 → 2181
    HormR; Domain present in hormone receptors
    cd00054
    Location:1717 → 1748
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:2067 → 2105
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:1508 → 1691
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00002
    Location:2534 → 2728
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam00053
    Location:1994 → 2033
    Laminin_EGF; Laminin EGF domain
    pfam15576
    Location:64 → 188
    DUF4661; Domain of unknown function (DUF4661)
    pfam16489
    Location:2201 → 2446
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

RNA

  1. XR_010054036.1 RNA Sequence

  2. XR_005487935.2 RNA Sequence

  3. XR_005487934.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88278.1 GenPept UniProtKB/Swiss-Prot:O88278

Gene LinkOut

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