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Clathrin adaptor complexes medium subunit family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 834706, updated on 18-Sep-2024

Summary

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Official Full Name
Clathrin adaptor complexes medium subunit family protein
Primary source
TAIR:AT5G46630
Locus tag
AT5G46630
See related
Araport:AT5G46630
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
adaptor protein-2 mu-adaptin; AP2M
Summary
clathrin adaptor complexes medium subunit family protein, contains Pfam profile: PF00928 adaptor complexes medium subunit family; similar to micro-adaptins of clathrin coated vesicle adaptor complexes
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Genomic context

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Location:
chromosome: 5
Exon count:
13
Sequence:
Chromosome: 5; NC_003076.8 (18920334..18923551)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene aluminum activated malate transporter family protein Neighboring gene uncharacterized protein Neighboring gene AT hook motif DNA-binding family protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The μ Subunit of Arabidopsis Adaptor Protein-2 Is Involved in Effector-Triggered Immunity Mediated by Membrane-Localized Resistance Proteins. Hatsugai N, et al. Mol Plant Microbe Interact, 2016 May. PMID 26828402
  2. The endocytosis of cellulose synthase in Arabidopsis is dependent on μ2, a clathrin-mediated endocytosis adaptin. Bashline L, et al. Plant Physiol, 2013 Sep. PMID 23843604, Free PMC Article
  3. Phosphorylation of ADAPTOR PROTEIN-2 μ-adaptin by ADAPTOR-ASSOCIATED KINASE1 regulates the tropic growth of Arabidopsis roots. Siao W, et al. Plant Cell, 2023 Sep 1. PMID 37440281, Free PMC Article
  4. Trafficking of the human transferrin receptor in plant cells: effects of tyrphostin A23 and brefeldin A. Ortiz-Zapater E, et al. Plant J, 2006 Dec. PMID 17059402
  5. Adaptor protein complex 2-mediated endocytosis is crucial for male reproductive organ development in Arabidopsis. Kim SY, et al. Plant Cell, 2013 Aug. PMID 23975898, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphorylation of ADAPTOR PROTEIN-2 mu-adaptin by ADAPTOR-ASSOCIATED KINASE1 regulates the tropic growth of Arabidopsis roots.
    Title: Phosphorylation of ADAPTOR PROTEIN-2 μ-adaptin by ADAPTOR-ASSOCIATED KINASE1 regulates the tropic growth of Arabidopsis roots.
  2. These results suggest that the mu subunit of adaptor protein 2 (AP-2) is involved in effector-triggered immunity mediated by plasma membrane-localized R proteins.[AP2M]
    Title: The μ Subunit of Arabidopsis Adaptor Protein-2 Is Involved in Effector-Triggered Immunity Mediated by Membrane-Localized Resistance Proteins.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_124033.4
NM_203166.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of clathrin adaptor complex IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plastid HDA PubMed 

General protein information

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Preferred Names
Clathrin adaptor complexes medium subunit family protein
NP_199475.1
  • Clathrin adaptor complexes medium subunit family protein; INVOLVED IN: intracellular protein transport, transport, vesicle-mediated transport; LOCATED IN: clathrin vesicle coat, plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Clathrin adaptor, mu subunit, conserved site (InterPro:IPR018240), Clathrin adaptor, mu subunit, C-terminal (InterPro:IPR008968), Clathrin adaptor, mu subunit (InterPro:IPR001392), Clathrin coat associated protein AP-50 (InterPro:IPR015629), Longin-like (InterPro:IPR011012); BEST Arabidopsis thaliana protein match is: Clathrin adaptor complexes medium subunit family protein (TAIR:AT1G60780.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
NP_974895.1
  • Clathrin adaptor complexes medium subunit family protein; INVOLVED IN: intracellular protein transport, transport, vesicle-mediated transport; LOCATED IN: clathrin vesicle coat, plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Clathrin adaptor, mu subunit, conserved site (InterPro:IPR018240), Clathrin adaptor, mu subunit, C-terminal (InterPro:IPR008968), Clathrin adaptor, mu subunit (InterPro:IPR001392), Clathrin coat associated protein AP-50 (InterPro:IPR015629), Longin-like (InterPro:IPR011012); BEST Arabidopsis thaliana protein match is: Clathrin adaptor complexes medium subunit family protein (TAIR:AT1G60780.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    18920334..18923551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_124033.4 → NP_199475.1  Clathrin adaptor complexes medium subunit family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_199475.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DI54, O23140
    UniProtKB/TrEMBL
    A0A178UQZ5, A0A5S9YC44
    Conserved Domains (2) summary
    cd09251
    Location:175 → 437
    AP-2_Mu2_Cterm; C-terminal domain of medium Mu2 subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-2
    cd14836
    Location:6 → 144
    AP2_Mu_N; AP-2 complex subunit mu N-terminal domain

  2. NM_203166.2 → NP_974895.1  Clathrin adaptor complexes medium subunit family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_974895.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F4KHJ7
    Conserved Domains (1) summary
    cd09251
    Location:175 → 413
    AP-2_Mu2_Cterm; C-terminal domain of medium Mu2 subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O23140.1

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