TT10 Laccase/Diphenol oxidase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: TT10
Official Full Name: Laccase/Diphenol oxidase family protein
Primary source: TAIR:AT5G48100
Locus tag: AT5G48100
See related: Araport:AT5G48100
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATLAC15; AtTT10; LAC15; LACCASE-LIKE 15; MDN11.18; MDN11_18; TRANSPARENT TESTA 10
Summary: Encodes a protein that is similar to laccase-like polyphenol oxidases. Involved in lignin and flavonoids biosynthesis. It has four conserved copper binding domains. Expressed in developing testa, where it colocalizes with the flavonoid end products proanthocyanidins and flavonols. Mutant plants exhibited a delay in developmentally determined browning of the testa, characterized by the pale brown color of seed coat. The tt10 mutant seeds accumulate more epicatechin monomers and more soluble proanthocyanidins than wild-type seeds. Flavonol composition was also affected in tt10 seeds, which exhibited a higher ratio of quercetin rhamnoside monomers versus dimers than wild-type seeds.
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Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

involved in oxidative polymerization of flavonoids
Title: TRANSPARENT TESTA10 encodes a laccase-like enzyme involved in oxidative polymerization of flavonoids in Arabidopsis seed coat.
involved in lignin synthesis in plants
Title: Involvement of AtLAC15 in lignin synthesis in seeds and in root elongation of Arabidopsis.

Submit: New GeneRIF Correction

NM_124184.2

Function	Evidence Code	Pubs
enables copper ion binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables hydroquinone:oxygen oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within flavonoid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lignin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within proanthocyanidin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to copper ion	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	ISM Inferred from Sequence Model more info

NP_199621.2

TRANSPARENT TESTA 10 (TT10); FUNCTIONS IN: copper ion binding, laccase activity; INVOLVED IN: lignin biosynthetic process, response to copper ion, flavonoid biosynthetic process; LOCATED IN: endomembrane system, apoplast; EXPRESSED IN: 8 plant structures; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, 4 anthesis, seedling growth, seed development stages; CONTAINS InterPro DOMAIN/s: Multicopper oxidase, type 3 (InterPro:IPR011707), Laccase (InterPro:IPR017761), Multicopper oxidase, type 2 (InterPro:IPR011706), Cupredoxin (InterPro:IPR008972), Multicopper oxidase, copper-binding site (InterPro:IPR002355), Multicopper oxidase, type 1 (InterPro:IPR001117); BEST Arabidopsis thaliana protein match is: laccase 14 (TAIR:AT5G09360.1); Has 10402 Blast hits to 8649 proteins in 1516 species: Archae - 36; Bacteria - 4416; Metazoa - 511; Fungi - 3532; Plants - 1551; Viruses - 0; Other Eukaryotes - 356 (source: NCBI BLink).